HBD and HBZ

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		HBD	HBZ
Description		hemoglobin subunit delta	hemoglobin subunit zeta
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GO Annotations	Cellular Component	Cytosol Hemoglobin Complex Haptoglobin-hemoglobin Complex Blood Microparticle	Hemoglobin Complex Haptoglobin-hemoglobin Complex Extracellular Exosome
	Molecular Function	Oxygen Carrier Activity Protein Binding Oxygen Binding Heme Binding Hemoglobin Alpha Binding Metal Ion Binding	Oxygen Carrier Activity Iron Ion Binding Protein Binding Oxygen Binding Heme Binding Metal Ion Binding
	Biological Process	Carbon Dioxide Transport Oxygen Transport Erythrocyte Development	Negative Regulation Of Transcription By RNA Polymerase II Carbon Dioxide Transport Oxygen Transport Erythrocyte Maturation Erythrocyte Development
Pathways		Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		Beta thalassemia/hemoglobin E disease ( 20183929) Hematology traits ( 23263863) Hemoglobin levels ( 26366553) Logical memory (delayed recall) in normal cognition ( 29274321) Logical memory (immediate recall) in normal cognition ( 29274321) Malaria ( 31844061) Mean corpuscular hemoglobin concentration ( 23263863)	Blood protein levels ( 30072576) Body mass index ( 26426971) Early cardiac repolarization ( 31600170) Hemoglobin ( 32888494) Hemoglobin levels ( 26366553) Mean corpuscular hemoglobin ( 27863252 29403010 32888494) Mean corpuscular hemoglobin concentration ( 29403010) Mean corpuscular volume ( 27863252 29403010) Red blood cell count ( 29403010 32888494)
Interacting Genes		6 interacting genes: APP HBA1 HBA2 HBM HBQ1 HBZ	30 interacting genes: APP CARD10 CCNDBP1 CYSRT1 DOCK8 FGFR3 GOLGA6L9 HBB HBD HBE1 HBG2 HBM HBQ1 HNRNPD HNRNPK IKBKG KHDRBS2 KHDRBS3 KRT31 KRT40 KRTAP10-3 KRTAP10-7 KRTAP10-9 MTUS2 NBPF19 NOTCH2NLA NTAQ1 RBMY1A1 SP1 UPF2
Entrez ID		3045	3050
HPRD ID		00787	00794
Ensembl ID		ENSG00000223609	ENSG00000130656
Uniprot IDs		A0N071 P02042	P02008
PDB IDs		1SHR 1SI4	1JEB 3W4U
Enriched GO Terms of Interacting Partners?		Hemoglobin Complex Haptoglobin-hemoglobin Complex Oxygen Carrier Activity Myeloid Cell Development Oxygen Transport Oxygen Binding Erythrocyte Development Hemopoiesis Heme Binding Carbon Dioxide Transport Cell Development Iron Ion Binding One-carbon Compound Transport Haptoglobin Binding Nitric Oxide Transport G Protein-coupled Receptor Binding Endocytic Vesicle Lumen Hydrogen Peroxide Catabolic Process Cellular Developmental Process Peroxidase Activity Hydrogen Peroxide Metabolic Process Metal Ion Binding Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Cellular Oxidant Detoxification Reactive Oxygen Species Metabolic Process Response To Hydrogen Peroxide Cellular Detoxification Acetylcholine Receptor Activator Activity Lipoprotein Particle Developmental Process Positive Regulation Of Protein Import Blood Microparticle PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Cell Maturation Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus Astrocyte Activation Involved In Immune Response	Hemoglobin Complex Haptoglobin-hemoglobin Complex Oxygen Carrier Activity Oxygen Transport Oxygen Binding Erythrocyte Development Myeloid Cell Development Hemoglobin Alpha Binding Carbon Dioxide Transport Hemopoiesis Heme Binding One-carbon Compound Transport Keratin Filament Intermediate Filament Regulation Of MRNA Splicing, Via Spliceosome Blood Microparticle MRNA Binding Regulation Of MRNA Processing Regulation Of MRNA Metabolic Process Regulation Of Alternative MRNA Splicing, Via Spliceosome Regulation Of RNA Splicing Cell Development Positive Regulation Of Amyloid Precursor Protein Catabolic Process Telomeric DNA Binding
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