HBD and HBM

Number of citations of the paper that reports this interaction (PubMedID 36949045)
82

Data Source:
BioGRID (two hybrid)

		HBD	HBM
Description		hemoglobin subunit delta	hemoglobin subunit mu
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Hemoglobin Complex Haptoglobin-hemoglobin Complex Blood Microparticle	Hemoglobin Complex Haptoglobin-hemoglobin Complex
	Molecular Function	Oxygen Carrier Activity Protein Binding Oxygen Binding Heme Binding Hemoglobin Alpha Binding Metal Ion Binding	Oxygen Carrier Activity Protein Binding Oxygen Binding Heme Binding Metal Ion Binding
	Biological Process	Carbon Dioxide Transport Oxygen Transport Erythrocyte Development	Oxygen Transport Erythrocyte Development
Pathways		Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		Beta thalassemia/hemoglobin E disease ( 20183929) Hematology traits ( 23263863) Hemoglobin levels ( 26366553) Logical memory (delayed recall) in normal cognition ( 29274321) Logical memory (immediate recall) in normal cognition ( 29274321) Malaria ( 31844061) Mean corpuscular hemoglobin concentration ( 23263863)	Body mass index ( 26426971) Glycated hemoglobin levels ( 31213470) Hemoglobin ( 32888494) Hemoglobin A1c levels ( 31217584) Hemoglobin levels ( 26366553) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 27863252 32888494) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular volume ( 28453575 27863252 32888494) Red blood cell count ( 32888494) Red cell distribution width ( 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)
Interacting Genes		6 interacting genes: APP HBA1 HBA2 HBM HBQ1 HBZ	6 interacting genes: HBB HBD HBE1 HBG2 HBZ VIRMA
Entrez ID		3045	3042
HPRD ID		00787
Ensembl ID		ENSG00000223609	ENSG00000206177
Uniprot IDs		A0N071 P02042	Q6B0K9
PDB IDs		1SHR 1SI4
Enriched GO Terms of Interacting Partners?		Hemoglobin Complex Haptoglobin-hemoglobin Complex Oxygen Carrier Activity Myeloid Cell Development Oxygen Transport Oxygen Binding Erythrocyte Development Hemopoiesis Heme Binding Carbon Dioxide Transport Cell Development Iron Ion Binding One-carbon Compound Transport Haptoglobin Binding Nitric Oxide Transport G Protein-coupled Receptor Binding Endocytic Vesicle Lumen Hydrogen Peroxide Catabolic Process Cellular Developmental Process Peroxidase Activity Hydrogen Peroxide Metabolic Process Metal Ion Binding Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Cellular Oxidant Detoxification Reactive Oxygen Species Metabolic Process Response To Hydrogen Peroxide Cellular Detoxification Acetylcholine Receptor Activator Activity Lipoprotein Particle Developmental Process Positive Regulation Of Protein Import Blood Microparticle PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Cell Maturation Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus Astrocyte Activation Involved In Immune Response	Hemoglobin Complex Haptoglobin-hemoglobin Complex Oxygen Carrier Activity Carbon Dioxide Transport Oxygen Transport Hemoglobin Alpha Binding One-carbon Compound Transport Oxygen Binding Erythrocyte Development Myeloid Cell Development Heme Binding Hemopoiesis Blood Microparticle Cell Development Cellular Developmental Process Haptoglobin Binding Nitric Oxide Transport Hemoglobin Binding Metal Ion Binding RNA N6-methyladenosine Methyltransferase Complex Hydrogen Peroxide Catabolic Process Endocytic Vesicle Lumen Erythrocyte Maturation Peroxidase Activity Hydrogen Peroxide Metabolic Process Developmental Process
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