USP43

Description		ubiquitin specific peptidase 43
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm
	Molecular Function	Cysteine-type Deubiquitinase Activity Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Ubiquitin-like Protein Peptidase Activity ISG15-specific Peptidase Activity
	Biological Process	Proteolysis Protein Deubiquitination Translesion Synthesis
Pathways		Termination of translesion DNA synthesis
Drugs
Diseases
GWAS		Coronary artery disease ( 29212778) Liver enzyme levels (alkaline phosphatase) ( 33972514) Serum alkaline phosphatase levels ( 33547301)
Novel Interacting Genes		1 novel interacting genes: CNTROB
Interacting Genes		3 interacting genes: H2BC3 HDAC1 YWHAE
Entrez ID		124739
HPRD ID		18926
Ensembl ID		ENSG00000154914
Uniprot IDs		Q70EL4
PDB IDs
Enriched GO Terms of Interacting Partners?		Hair Follicle Placode Formation Krueppel-associated Box Domain Binding Histone Deacetylase Binding Hippocampus Development Protein Decrotonylase Activity Histone Decrotonylase Activity Protein Lysine Delactylase Activity Fungiform Papilla Formation Protein Domain Specific Binding Regulation Of Heart Rate By Hormone Regulation Of Heart Rate By Chemical Signal Negative Regulation Of Calcium Ion Export Across Plasma Membrane Regulation Of Calcium Ion Export Across Plasma Membrane Phosphoserine Residue Binding Positive Regulation Of Toll-like Receptor Signaling Pathway Protein Heterodimerization Activity Negative Regulation Of Myotube Differentiation Enzyme Binding Host-mediated Suppression Of Viral Transcription Histone Deacetylase Activity Eyelid Development In Camera-type Eye Sin3-type Complex RNA Polymerase II Core Promoter Sequence-specific DNA Binding Negative Regulation Of Androgen Receptor Signaling Pathway Cellular Response To Platelet-derived Growth Factor Stimulus Host-mediated Suppression Of Viral Proces Protein Deacetylation NuRD Complex Protein Lysine Deacetylase Activity Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Core Promoter Sequence-specific DNA Binding Histone Deacetylase Activity, Hydrolytic Mechanism Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Linear Amides Positive Regulation Of Oligodendrocyte Differentiation Membrane Repolarization During Action Potential Protein Localization To Endoplasmic Reticulum Membrane Repolarization During Cardiac Muscle Cell Action Potential Negative Regulation Of Toll-like Receptor Signaling Pathway Positive Regulation Of Protein Export From Nucleus Positive Regulation Of Hippo Signaling Calcium Channel Inhibitor Activity Intracellular Potassium Ion Homeostasis Centrosome Separation
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