H2AZ1 and RNF168

Number of citations of the paper that reports this interaction (PubMedID 32424115)
57

Data Source:
BioGRID (enzymatic study)

		H2AZ1	RNF168
Description		H2A.Z variant histone 1	ring finger protein 168
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GO Annotations	Cellular Component	Nucleosome Euchromatin Heterochromatin Barr Body Nucleus Chromosome Extracellular Exosome	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytosol Protein-containing Complex Site Of Double-strand Break Catalytic Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding DNA Binding Protein Binding Structural Constituent Of Chromatin Chromatin DNA Binding Nucleosomal DNA Binding Protein Heterodimerization Activity	Chromatin Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Nucleosome Binding Histone Binding Ubiquitin Binding Metal Ion Binding Ubiquitin Protein Ligase Activity K63-linked Polyubiquitin Modification-dependent Protein Binding Histone Ubiquitin Ligase Activity Histone H2AK15 Ubiquitin Ligase Activity
	Biological Process	Chromatin Organization Heterochromatin Formation Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Estradiol Stimulus	DNA Damage Checkpoint Signaling DNA Metabolic Process DNA Repair Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining Chromatin Organization Ubiquitin-dependent Protein Catabolic Process DNA Damage Response Response To Radiation Response To Ionizing Radiation Protein Ubiquitination Negative Regulation Of Transcription Elongation By RNA Polymerase II Interstrand Cross-link Repair Epigenetic Regulation Of Gene Expression Isotype Switching Positive Regulation Of DNA Repair Protein K63-linked Ubiquitination Double-strand Break Repair Via Classical Nonhomologous End Joining DNA Repair-dependent Chromatin Remodeling
Pathways		Amyloid fiber formation	SUMOylation of DNA damage response and repair proteins Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends G2/M DNA damage checkpoint
Drugs
Diseases			RIDDLE syndrome
GWAS			Fat distribution (HIV) ( 21897333) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Triglyceride levels ( 32203549)
Interacting Genes		8 interacting genes: FH INCENP MAGEC1 NCAPH PIAS1 RNF168 RNF169 USP16	40 interacting genes: ALAS1 ATF6 DGCR8 DHX9 ECPAS H2AC13 H2AC18 H2AC20 H2AC4 H2AZ1 H2BC21 H2BC3 HDAC6 JMJD1C KDM1A KDM4A KMT5A LAPTM5 MACROH2A1 PALB2 PARP1 RABGEF1 RNF11 RNF126 SQSTM1 SUMO2 TNFAIP3 TOP2A TRIM8 UBC UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E2 UBE2G2 UBE2L3 UBE2N USP7 WBP2
Entrez ID		3015	165918
HPRD ID		00823	08190
Ensembl ID		ENSG00000164032	ENSG00000163961
Uniprot IDs		P0C0S5	Q8IYW5
PDB IDs		1F66 3WA9 4CAY 4NFT 5B31 5B32 5B33 5CHL 5FUG 5Z30 6JOU 6KO2 7YRD 7YRG 8JHF 8T9F 8THU 9C62	3L11 4GB0 5XIS 5XIT 5XIU 5YDK 8SMW 8SMX 8SMY 8SMZ 8SN0 8SN1 8SN2 8SN3 8SN4 8SN5 8SN6 8SN7 8SN8 8SN9 8SNA 8TXV 8TXW 8TXX 8U13 8U14 8UPF 8UQ8 8UQ9 8UQA 8UQB 8UQC 8UQD 8UQE 8X7I 8X7J 8X7K 9IPU
Enriched GO Terms of Interacting Partners?		DNA Damage Response Site Of Double-strand Break Histone Binding DNA Repair K63-linked Polyubiquitin Modification-dependent Protein Binding Positive Regulation Of Chromosome Separation Positive Regulation Of Chromosome Segregation Nucleosome Binding Chromosome Regulation Of DNA Repair Double-strand Break Repair DNA Recombination DNA Metabolic Process Cellular Response To Stress Fumarate Metabolic Process Fumarate Hydratase Activity Nucleus Meiotic Spindle Midzone Post-translational Protein Modification Positive Regulation Of Ribosome Biogenesis Double-strand Break Repair Via Nonhomologous End Joining Histone H2AK15 Ubiquitin Ligase Activity Regulation Of Chromosome Separation Nuclear Division Regulation Of Cell Cycle Meiotic Spindle Midzone Assembly Cell Division Female Meiosis Chromosome Separation Ubiquitin Binding Regulation Of DNA Metabolic Process Histone Ubiquitin Ligase Activity Regulation Of Cellular Response To Stress Positive Regulation Of DNA Repair Regulation Of Chromosome Segregation Chromosome Segregation Mitotic Cell Cycle Recombinational Repair Double-strand Break Repair Via Homologous Recombination Positive Regulation Of Translational Elongation Meiotic Chromosome Separation Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Double-strand Break Repair Regulation Of Arginine Metabolic Process Female Meiosis Chromosome Segregation Nucleoplasm Chromosome Passenger Complex Regulation Of Ribosome Biogenesis Mitotic Nuclear Division Histone H2A Deubiquitinase Activity Meiotic Chromosome Condensation	Post-translational Protein Modification Ubiquitin Conjugating Enzyme Activity Protein Polyubiquitination Protein Modification By Small Protein Conjugation Chromatin Organization Protein Ubiquitination Chromatin Remodeling Nucleus Protein Modification Process Structural Constituent Of Chromatin Protein K48-linked Ubiquitination Proteolysis Involved In Protein Catabolic Process Nucleosome Proteolysis Nucleoplasm Regulation Of Gene Expression Epigenetic Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Protein Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of Macromolecule Metabolic Process Modification-dependent Protein Catabolic Process Protein Heterodimerization Activity Negative Regulation Of Gene Expression, Epigenetic Ubiquitin-protein Transferase Activity Negative Regulation Of Gene Expression Enzyme Binding Cellular Response To Stress Ubiquitin Protein Ligase Binding Chromosome Negative Regulation Of Macromolecule Metabolic Process Response To Stress Regulation Of Metabolic Process Ubiquitin-dependent Protein Catabolic Process Macromolecule Catabolic Process Negative Regulation Of Metabolic Process Protein Monoubiquitination Macromolecule Metabolic Process Regulation Of Protein Ubiquitination Heterochromatin Formation Protein K63-linked Ubiquitination Protein-containing Complex Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process DNA Damage Response Regulation Of Post-translational Protein Modification Histone H3K9 Demethylase Activity Chromatin DNA Binding Transferase Activity
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