H2AZ1 and RNF169

Number of citations of the paper that reports this interaction (PubMedID 28506460)
66

Data Source:
BioGRID (pull down)

		H2AZ1	RNF169
Description		H2A.Z variant histone 1	ring finger protein 169
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GO Annotations	Cellular Component	Nucleosome Euchromatin Heterochromatin Barr Body Nucleus Chromosome Extracellular Exosome	Nucleus Nucleoplasm Chromosome Nucleolus Cytosol Nuclear Body Site Of Double-strand Break
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding DNA Binding Protein Binding Structural Constituent Of Chromatin Chromatin DNA Binding Nucleosomal DNA Binding Protein Heterodimerization Activity	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Nucleosome Binding Metal Ion Binding Ubiquitin Protein Ligase Activity Ubiquitin-modified Histone Reader Activity K63-linked Polyubiquitin Modification-dependent Protein Binding
	Biological Process	Chromatin Organization Heterochromatin Formation Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Estradiol Stimulus	Double-strand Break Repair Via Homologous Recombination DNA Repair Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining Chromatin Organization DNA Damage Response Protein Ubiquitination Negative Regulation Of Double-strand Break Repair
Pathways		Amyloid fiber formation
Drugs
Diseases
GWAS			Appendicular lean mass ( 33097823)
Interacting Genes		8 interacting genes: FH INCENP MAGEC1 NCAPH PIAS1 RNF168 RNF169 USP16	11 interacting genes: CEP70 DYRK1A GOLGA2 H2AC18 H2AC4 H2AZ1 HOOK2 HSF2BP PIBF1 UBC UBE2E1
Entrez ID		3015	254225
HPRD ID		00823	19383
Ensembl ID		ENSG00000164032	ENSG00000166439
Uniprot IDs		P0C0S5	Q8NCN4
PDB IDs		1F66 3WA9 4CAY 4NFT 5B31 5B32 5B33 5CHL 5FUG 5Z30 6JOU 6KO2 7YRD 7YRG 8JHF 8T9F 8THU 9C62	5GG4 5VEY
Enriched GO Terms of Interacting Partners?		DNA Damage Response Site Of Double-strand Break Histone Binding DNA Repair K63-linked Polyubiquitin Modification-dependent Protein Binding Positive Regulation Of Chromosome Separation Positive Regulation Of Chromosome Segregation Nucleosome Binding Chromosome Regulation Of DNA Repair Double-strand Break Repair DNA Recombination DNA Metabolic Process Cellular Response To Stress Fumarate Metabolic Process Fumarate Hydratase Activity Nucleus Meiotic Spindle Midzone Post-translational Protein Modification Positive Regulation Of Ribosome Biogenesis Double-strand Break Repair Via Nonhomologous End Joining Histone H2AK15 Ubiquitin Ligase Activity Regulation Of Chromosome Separation Nuclear Division Regulation Of Cell Cycle Meiotic Spindle Midzone Assembly Cell Division Female Meiosis Chromosome Separation Ubiquitin Binding Regulation Of DNA Metabolic Process Histone Ubiquitin Ligase Activity Regulation Of Cellular Response To Stress Positive Regulation Of DNA Repair Regulation Of Chromosome Segregation Chromosome Segregation Mitotic Cell Cycle Recombinational Repair Double-strand Break Repair Via Homologous Recombination Positive Regulation Of Translational Elongation Meiotic Chromosome Separation Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Double-strand Break Repair Regulation Of Arginine Metabolic Process Female Meiosis Chromosome Segregation Nucleoplasm Chromosome Passenger Complex Regulation Of Ribosome Biogenesis Mitotic Nuclear Division Histone H2A Deubiquitinase Activity Meiotic Chromosome Condensation	Negative Regulation Of Gene Expression Structural Constituent Of Chromatin Nucleosome Heterochromatin Formation Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Metabolic Process Chromatin Remodeling Centrosome Peptidyl-tyrosine Phosphorylation Histone H3T45 Kinase Activity Mitotic Spindle Assembly Chromosome Epigenetic Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Microtubule Negative Regulation Of Biosynthetic Process Cytoskeleton Chromatin Organization Protein Heterodimerization Activity Negative Regulation Of Prostaglandin Biosynthetic Process Mitotic Spindle Organization Spindle Assembly Microtubule Organizing Center Negative Regulation Of Tyrosine Phosphorylation Of STAT Protein Interleukin-4 Receptor Binding Protein Modification Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Protein Glycosylation Microtubule Cytoskeleton Organization ISG15 Transferase Activity Activation Of Janus Kinase Activity Microtubule Cytoskeleton Organization Involved In Mitosis Negative Regulation Of Heterochromatin Formation FHF Complex Regulation Of Neurofibrillary Tangle Assembly Splicing Factor Binding Golgi Disassembly ISG15-protein Conjugation Regulation Of Protein Glycosylation Barr Body Female Meiosis I Regulation Of Microtubule Cytoskeleton Organization Spindle Organization Protein Localization To Perinuclear Region Of Cytoplasm
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