GUCA1A and C1QTNF5

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		GUCA1A	C1QTNF5
Description		guanylate cyclase activator 1A	C1q and TNF related 5
Image		No pdb structure
GO Annotations	Cellular Component	Photoreceptor Outer Segment Photoreceptor Inner Segment Membrane Cell Projection Photoreceptor Disc Membrane Cone Photoreceptor Outer Segment	Extracellular Region Collagen Trimer Extracellular Space Plasma Membrane Bicellular Tight Junction Membrane Apical Plasma Membrane Lateral Plasma Membrane Transport Vesicle Protein-containing Complex Cell Projection
	Molecular Function	Calcium Ion Binding Protein Binding Calcium Sensitive Guanylate Cyclase Activator Activity Guanylate Cyclase Regulator Activity Metal Ion Binding	Protein Binding Identical Protein Binding
	Biological Process	Signal Transduction Visual Perception Phototransduction Regulation Of Signal Transduction Positive Regulation Of CGMP-mediated Signaling Positive Regulation Of Guanylate Cyclase Activity Cellular Response To Calcium Ion	Protein Secretion Inner Ear Development
Pathways		Inactivation, recovery and regulation of the phototransduction cascade
Drugs		Myristic acid
Diseases		Cone-rod dystrophy and cone dystrophy, including: Cone-rod dystrophy (CORD); Cone dystrophy (COD); Retinal cone dystrophy (RCD)
GWAS		Femur bone mineral density x serum urate levels interaction ( 34046847) Spatial processing ( 31596458)	Blood protein levels ( 30072576) Lifespan ( 25918517)
Interacting Genes		9 interacting genes: AGR2 C1QTNF5 DDIT4L DEFB118 GSC2 GUCY2D HSPB1 KATNAL1 PRKAR1B	5 interacting genes: GUCA1A MFRP SGTA SGTB SLC2A4
Entrez ID		2978	114902
HPRD ID		02648	10575
Ensembl ID		ENSG00000048545	ENSG00000223953
Uniprot IDs		P43080	Q9BXJ0
PDB IDs			4F3J 4NN0
Enriched GO Terms of Interacting Partners?			TRC Complex Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Establishment Of Protein Localization To Endoplasmic Reticulum Protein Targeting To ER Positive Regulation Of Guanylate Cyclase Activity Protein Targeting To Membrane Amylopectin Biosynthetic Process D-glucose Uniporter Activity Regulation Of Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Guanylate Cyclase Regulator Activity Positive Regulation Of Brain-derived Neurotrophic Factor Receptor Signaling Pathway Positive Regulation Of CGMP-mediated Signaling Calcium Sensitive Guanylate Cyclase Activator Activity Visual Perception Sensory Perception Of Light Stimulus Nervous System Process Cone Photoreceptor Outer Segment Establishment Of Protein Localization To Membrane Protein Targeting BAT3 Complex Binding Molecular Adaptor Activity Negative Regulation Of ERAD Pathway Insulin-responsive Compartment Glucose Import In Response To Insulin Stimulus White Fat Cell Proliferation Negative Regulation Of RIG-I Signaling Pathway Dehydroascorbic Acid Transport Fat Cell Proliferation D-glucose Transmembrane Transporter Activity Membrane Short-term Memory Negative Regulation Of Macrophage Cytokine Production Regulation Of CGMP-mediated Signaling Negative Regulation Of Interferon-beta Production Establishment Of Protein Localization To Organelle Tail-anchored Membrane Protein Insertion Into ER Membrane Trans-Golgi Network Transport Vesicle
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