GUCA1A and DEFB118

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		GUCA1A	DEFB118
Description		guanylate cyclase activator 1A	defensin beta 118
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Photoreceptor Outer Segment Photoreceptor Inner Segment Membrane Cell Projection Photoreceptor Disc Membrane Cone Photoreceptor Outer Segment	Extracellular Region
	Molecular Function	Calcium Ion Binding Protein Binding Calcium Sensitive Guanylate Cyclase Activator Activity Guanylate Cyclase Regulator Activity Metal Ion Binding	Lipopolysaccharide Binding Protein Binding Membrane Destabilizing Activity
	Biological Process	Signal Transduction Visual Perception Phototransduction Regulation Of Signal Transduction Positive Regulation Of CGMP-mediated Signaling Positive Regulation Of Guanylate Cyclase Activity Cellular Response To Calcium Ion	Defense Response Cell-matrix Adhesion Negative Regulation Of Cell Adhesion Spermatogenesis Killing Of Cells Of Another Organism Negative Regulation Of Lipopolysaccharide-mediated Signaling Pathway Defense Response To Bacterium Innate Immune Response Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide
Pathways		Inactivation, recovery and regulation of the phototransduction cascade	Beta defensins Defensins
Drugs		Myristic acid
Diseases		Cone-rod dystrophy and cone dystrophy, including: Cone-rod dystrophy (CORD); Cone dystrophy (COD); Retinal cone dystrophy (RCD)
GWAS		Femur bone mineral density x serum urate levels interaction ( 34046847) Spatial processing ( 31596458)	Prudent dietary pattern ( 28644415) TPE interval (resting) ( 32386560)
Interacting Genes		9 interacting genes: AGR2 C1QTNF5 DDIT4L DEFB118 GSC2 GUCY2D HSPB1 KATNAL1 PRKAR1B	1 interacting genes: GUCA1A
Entrez ID		2978	117285
HPRD ID		02648	09629
Ensembl ID		ENSG00000048545	ENSG00000131068
Uniprot IDs		P43080	A0A384MTK2 Q96PH6
PDB IDs
Enriched GO Terms of Interacting Partners?			Positive Regulation Of Guanylate Cyclase Activity Guanylate Cyclase Regulator Activity Positive Regulation Of CGMP-mediated Signaling Calcium Sensitive Guanylate Cyclase Activator Activity Cone Photoreceptor Outer Segment Regulation Of CGMP-mediated Signaling Positive Regulation Of Lyase Activity Positive Regulation Of Cyclase Activity Photoreceptor Disc Membrane Phototransduction Photoreceptor Inner Segment Detection Of Light Stimulus Photoreceptor Outer Segment Cellular Response To Calcium Ion Regulation Of Purine Nucleotide Metabolic Process Detection Of Abiotic Stimulus Response To Calcium Ion Positive Regulation Of Small Molecule Metabolic Process Cellular Response To Metal Ion Visual Perception Sensory Perception Of Light Stimulus Detection Of Stimulus Positive Regulation Of Phosphate Metabolic Process Positive Regulation Of Catalytic Activity Regulation Of Small Molecule Metabolic Process Response To Metal Ion Response To Light Stimulus
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