PILRA and TOM1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PILRA	TOM1
Description		paired immunoglobin like type 2 receptor alpha	target of myb1 membrane trafficking protein
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GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Membrane Extracellular Exosome	Cytoplasm Endosome Early Endosome Golgi Apparatus Cytosol Plasma Membrane Endosome Membrane Membrane Early Endosome Membrane Azurophil Granule Membrane Specific Granule Membrane Extracellular Exosome
	Molecular Function	Protein Binding MHC Class I Protein Binding	Protein Binding Phosphatidylinositol-5-phosphate Binding Clathrin Binding Polyubiquitin Modification-dependent Protein Binding Clathrin Heavy Chain Binding Phosphatidylinositol Binding Ubiquitin Binding Myosin VI Binding
	Biological Process	Signal Transduction	Endocytosis Signal Transduction Protein Transport Endosomal Transport Substrate Localization To Autophagosome Autophagosome-lysosome Fusion Positive Regulation Of Autophagosome Maturation Regulation Of Endosome Organization
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	Neutrophil degranulation
Drugs
Diseases
GWAS		Advanced age-related macular degeneration ( 26691988) Blood protein levels ( 30072576) Brain morphology (MOSTest) ( 32665545) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Red cell distribution width ( 32888494) Refractive error ( 32231278) Subcortical volume (MOSTest) ( 32665545)	Cholesterol, total ( 24097068) HDL cholesterol ( 29404214) High density lipoprotein cholesterol levels ( 31217584) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Hippocampal volume in mild cognitive impairment ( 29274321) Inflammatory bowel disease ( 28067908) Low density lipoprotein cholesterol levels ( 32154731) Multiple myeloma ( 26007630) Multiple myeloma and monoclonal gammopathy ( 26007630) Plasma proprotein convertase subtilisin/kexin type 9 levels in stable coronary artery disease ( 29748315) Total cholesterol levels ( 28334899) Triglyceride levels ( 34074324) Ulcerative colitis ( 28067908) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		10 interacting genes: DNPH1 FAM114A2 FCAR PAICS PFDN5 PTPN11 PTPN6 SORBS1 TOM1 UROD	25 interacting genes: APP BBS4 BBS5 BBS9 CLTC DAZAP2 EEA1 HACL2 LITAF LRRC20 NAA11 NEDD4 OGT PILRA PTBP2 RPS27 SMURF1 SNCA SSBP2 TOLLIP UBC UBE2D1 WWP2 ZFYVE16 ZNF512B
Entrez ID		29992	10043
HPRD ID		05631	05265
Ensembl ID		ENSG00000085514	ENSG00000100284
Uniprot IDs		Q9UKJ1	B3KUF5 O60784
PDB IDs		3WUZ 3WV0 4NFB 5XO2 5XOF	1ELK 1WRD 2N2N 2N9D 6J56
Enriched GO Terms of Interacting Partners?		Neutrophil Activation Negative Regulation Of Neutrophil Activation Non-membrane Spanning Protein Tyrosine Phosphatase Activity Regulation Of Neutrophil Activation Neutrophil Activation Involved In Immune Response Myeloid Leukocyte Activation Peptidyl-tyrosine Dephosphorylation Platelet Formation Megakaryocyte Development Insulin Receptor Binding Positive Regulation Of Insulin Receptor Signaling Pathway Positive Regulation Of Cellular Response To Insulin Stimulus Carboxy-lyase Activity Regulation Of Lipopolysaccharide-mediated Signaling Pathway Signaling Receptor Complex Adaptor Activity Positive Regulation Of D-glucose Import Regulation Of Type I Interferon-mediated Signaling Pathway T Cell Costimulation Positive Regulation Of D-glucose Transmembrane Transport Phosphotyrosine Residue Binding Regulation Of Cell Adhesion Mediated By Integrin IgA Receptor Activity RNA Polymerase III Assembly RNA Polymerase I Assembly Epididymis Development Negative Regulation Of Cortisol Secretion Negative Regulation Of Growth Hormone Secretion Regulation Of D-glucose Import Uroporphyrinogen Decarboxylase Activity Phosphoribosylaminoimidazolesuccinocarboxamide Synthase Activity Phosphoribosylaminoimidazole Carboxylase Activity Myeloid Cell Development Regulation Of Insulin Receptor Signaling Pathway Nucleoside Monophosphate Metabolic Process Negative Regulation Of T Cell Proliferation Regulation Of D-glucose Transmembrane Transport Regulation Of Cellular Response To Insulin Stimulus Specific Granule Membrane RNA Polymerase II Core Complex Assembly Protein Dephosphorylation Intestinal Epithelial Cell Migration Myosin VI Binding 5-hydroxymethyl-dUMP N-hydrolase Activity Immune Effector Process Negative Regulation Of Lymphocyte Proliferation Negative Regulation Of Mononuclear Cell Proliferation Cell Adhesion Molecule Binding Protein Tyrosine Phosphatase Activity Negative Regulation Of Leukocyte Proliferation IgA Binding	BBSome Protein-containing Complex Protein Localization To Vacuole Cytoplasm Negative Regulation Of Potassium Ion Export Across Plasma Membrane Protein Localization To Organelle Centriolar Satellite Establishment Of Localization In Cell Protein Targeting To Vacuole Ciliary Membrane Protein Localization To Lysosome Potassium Channel Inhibitor Activity Establishment Of Protein Localization To Vacuole Cytosol Intracellular Protein Localization Protein Transport Receptor Internalization Modification-dependent Protein Catabolic Process Regulation Of Potassium Ion Export Across Plasma Membrane 1-phosphatidylinositol Binding Early Endosome Membrane Intracellular Transport Negative Regulation Of Transcription By RNA Polymerase II Endocytosis Regulation Of Neurotransmitter Uptake Protein Serine/threonine Kinase Binding Cellular Response To Copper Ion Establishment Of Melanosome Localization Pericentriolar Material Melanosome Localization Establishment Of Protein Localization Melanosome Transport Pigment Granule Transport Establishment Of Vesicle Localization Receptor Catabolic Process Negative Regulation Of Potassium Ion Transmembrane Transport Proteolysis Involved In Protein Catabolic Process Ubiquitin-protein Transferase Activity WW Domain Binding Regulation Of Presynapse Organization Regulation Of Long-term Neuronal Synaptic Plasticity Low-density Lipoprotein Particle Receptor Binding Regulation Of Presynapse Assembly Regulation Of Monoatomic Cation Transmembrane Transport Pigment Granule Localization Negative Regulation Of MiRNA Transcription Positive Regulation Of Macromolecule Metabolic Process Amyloid-beta Complex Growth Cone Lamellipodium Response To Copper Ion
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