PILRA and DNPH1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		PILRA	DNPH1
Description		paired immunoglobin like type 2 receptor alpha	2'-deoxynucleoside 5'-phosphate N-hydrolase 1
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GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Membrane Extracellular Exosome	Nucleus Cytoplasm Cytosol Extracellular Exosome
	Molecular Function	Protein Binding MHC Class I Protein Binding	Protein Binding Hydrolase Activity Hydrolase Activity, Acting On Glycosyl Bonds Hydrolase Activity, Hydrolyzing N-glycosyl Compounds Identical Protein Binding Protein Homodimerization Activity 5-hydroxymethyl-dUMP N-hydrolase Activity
	Biological Process	Signal Transduction	Allantoin Metabolic Process Purine Nucleotide Catabolic Process Nucleoside Metabolic Process Nucleotide Metabolic Process Deoxyribonucleoside Monophosphate Catabolic Process Positive Regulation Of Cell Growth Epithelial Cell Differentiation Nucleoside Salvage DGMP Catabolic Process Carbohydrate Derivative Metabolic Process
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	Purine catabolism
Drugs
Diseases
GWAS		Advanced age-related macular degeneration ( 26691988) Blood protein levels ( 30072576) Brain morphology (MOSTest) ( 32665545) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Red cell distribution width ( 32888494) Refractive error ( 32231278) Subcortical volume (MOSTest) ( 32665545)	Adult hearing difficulty ( 31564434)
Interacting Genes		10 interacting genes: DNPH1 FAM114A2 FCAR PAICS PFDN5 PTPN11 PTPN6 SORBS1 TOM1 UROD	4 interacting genes: DDIT4L PILRA POT1 TERF1
Entrez ID		29992	10591
HPRD ID		05631	06707
Ensembl ID		ENSG00000085514	ENSG00000112667
Uniprot IDs		Q9UKJ1	O43598
PDB IDs		3WUZ 3WV0 4NFB 5XO2 5XOF	4P5E 8OS9 8OSC 8QHQ 8QHR 8RPS 8RPT 8RQD 9DA1 9DA2 9DA3 9DA4 9DA5 9DA6
Enriched GO Terms of Interacting Partners?		Neutrophil Activation Negative Regulation Of Neutrophil Activation Non-membrane Spanning Protein Tyrosine Phosphatase Activity Regulation Of Neutrophil Activation Neutrophil Activation Involved In Immune Response Myeloid Leukocyte Activation Peptidyl-tyrosine Dephosphorylation Platelet Formation Megakaryocyte Development Insulin Receptor Binding Positive Regulation Of Insulin Receptor Signaling Pathway Positive Regulation Of Cellular Response To Insulin Stimulus Carboxy-lyase Activity Regulation Of Lipopolysaccharide-mediated Signaling Pathway Signaling Receptor Complex Adaptor Activity Positive Regulation Of D-glucose Import Regulation Of Type I Interferon-mediated Signaling Pathway T Cell Costimulation Positive Regulation Of D-glucose Transmembrane Transport Phosphotyrosine Residue Binding Regulation Of Cell Adhesion Mediated By Integrin IgA Receptor Activity RNA Polymerase III Assembly RNA Polymerase I Assembly Epididymis Development Negative Regulation Of Cortisol Secretion Negative Regulation Of Growth Hormone Secretion Regulation Of D-glucose Import Uroporphyrinogen Decarboxylase Activity Phosphoribosylaminoimidazolesuccinocarboxamide Synthase Activity Phosphoribosylaminoimidazole Carboxylase Activity Myeloid Cell Development Regulation Of Insulin Receptor Signaling Pathway Nucleoside Monophosphate Metabolic Process Negative Regulation Of T Cell Proliferation Regulation Of D-glucose Transmembrane Transport Regulation Of Cellular Response To Insulin Stimulus Specific Granule Membrane RNA Polymerase II Core Complex Assembly Protein Dephosphorylation Intestinal Epithelial Cell Migration Myosin VI Binding 5-hydroxymethyl-dUMP N-hydrolase Activity Immune Effector Process Negative Regulation Of Lymphocyte Proliferation Negative Regulation Of Mononuclear Cell Proliferation Cell Adhesion Molecule Binding Protein Tyrosine Phosphatase Activity Negative Regulation Of Leukocyte Proliferation IgA Binding	Shelterin Complex Nuclear Telomere Cap Complex Telomeric D-loop Disassembly G-rich Strand Telomeric DNA Binding Telomeric Loop Disassembly Telomere Capping Negative Regulation Of Telomere Maintenance Via Telomerase Telomere Maintenance Via Telomerase RNA-templated DNA Biosynthetic Process Telomere Maintenance Via Telomere Lengthening Telomeric DNA Binding Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Regulation Of Telomere Maintenance Via Telomere Lengthening Positive Regulation Of Telomere Maintenance Negative Regulation Of Chromosome Organization DNA Biosynthetic Process Negative Regulation Of Establishment Of Protein Localization To Telomere Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Telomere Maintenance Negative Regulation Of Establishment Of RNA Localization To Telomere Positive Regulation Of Chromosome Organization Regulation Of DNA Biosynthetic Process Positive Regulation Of Shelterin Complex Assembly Positive Regulation Of DNA Strand Elongation Positive Regulation Of Telomeric D-loop Disassembly G-rich Single-stranded DNA Binding Regulation Of Telomere Maintenance Telomere Organization Negative Regulation Of DNA Metabolic Process Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Positive Regulation Of Telomeric Loop Disassembly Chromosome, Telomeric Region 8-hydroxy-2'-deoxyguanosine DNA Binding Telomeric G-quadruplex DNA Binding Telomeric D-loop Binding Telomere Assembly Single-stranded Telomeric DNA Binding Regulation Of Chromosome Organization Regulation Of Establishment Of Protein Localization To Telomere Regulation Of Establishment Of Protein Localization To Chromosome Telomerase Activity Positive Regulation Of DNA Metabolic Process Ankyrin Repeat Binding Telomerase Inhibitor Activity Establishment Of Protein Localization To Telomere Meiotic Telomere Clustering
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