PNMA3 and APTX

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		PNMA3	APTX
Name		PNMA family member 3	aprataxin
Structure		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleolus	Chromatin Nucleus Nucleoplasm Nucleolus Cytoplasm
	Molecular Function	Nucleic Acid Binding Protein Binding Zinc Ion Binding Metal Ion Binding	DNA Binding Chromatin Binding Damaged DNA Binding Double-stranded DNA Binding Single-stranded DNA Binding Double-stranded RNA Binding Catalytic Activity Protein Binding Zinc Ion Binding Phosphoglycolate Phosphatase Activity Hydrolase Activity Mismatched DNA Binding DNA 5'-adenosine Monophosphate Hydrolase Activity Polynucleotide 3'-phosphatase Activity Metal Ion Binding Phosphoprotein Binding DNA-3'-diphospho-5'-guanosine Diphosphatase Single-strand Break-containing DNA Binding
	Biological Process	Positive Regulation Of Apoptotic Process	Single Strand Break Repair DNA Repair DNA Damage Response Regulation Of Protein Stability
Diseases		None	Ataxia with ocular apraxia (AOA), including: Ataxia telangiectasia (AT); Ataxia telangiectasia like disorder (ATLD); Ataxia oculomotor apraxia type 1 (AOA1); Ataxia oculomotor apraxia type 2 (AOA2) Coenzyme Q10 deficiency
GWAS		No GWAS studies recorded	Height ( 28552196 ) Menopause (age at onset) ( 26414677 )
Interacting Genes		12 interacting genes: APTX C19orf25 CCDC187 CNNM3 LNX1 PRPF31 RPH3AL SLC25A37 SMG9 TIGD3 UBQLN2 ZBTB47	18 interacting genes: CALCOCO1 CEP350 CNTROB FLAD1 HIVEP1 MAPKBP1 MBP PARP1 PICK1 PNMA1 PNMA3 SYT17 TP53 TRIM37 TSPYL2 XRCC1 XRCC4 ZNF639
Entrez ID		29944	54840
HPRD ID		06677	05892
Ensembl ID		ENSG00000183837	ENSG00000137074
Uniprot IDs		Q9UL41	A0A5K1VW64 Q7Z2E3
PDB IDs		Not available	3KT9 4NDF 4NDG 4NDH 4NDI 6CVO 6CVP 6CVQ 6CVR 6CVS 6CVT
GO Terms Enriched among Interactors		None	Negative Regulation Of Telomere Maintenance Regulation Of Base-excision Repair Negative Regulation Of DNA Metabolic Process Mitochondrial DNA Repair Nucleolus Enzyme Binding Positive Regulation Of Programmed Necrotic Cell Death Regulation Of Cellular Component Organization Double-strand Break Repair Negative Regulation Of Chromosome Organization Chromatin Binding Site Of Double-strand Break Mitochondrial DNA Metabolic Process Regulation Of Telomere Maintenance Regulation Of Catalytic Activity Protein Localization To Organelle Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Response To Ionizing Radiation Protein Localization To Site Of Double-strand Break Response To X-ray Negative Regulation Of DNA Replication NAD+-histone H3S10 Serine ADP-ribosyltransferase Activity Regulation Of Programmed Necrotic Cell Death NAD+-histone H2BS6 Serine ADP-ribosyltransferase Activity Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Nucleobase-containing Compound Metabolic Process Site Of DNA Damage NAD+-histone H2BE35 Glutamate ADP-ribosyltransferase Activity Regulation Of Organelle Organization Negative Regulation Of Cellular Component Organization NAD+-protein-histidine ADP-ribosyltransferase Activity NAD+-protein-tyrosine ADP-ribosyltransferase Activity Positive Regulation Of Metalloendopeptidase Activity Negative Regulation Of Helicase Activity Negative Regulation Of G1 To G0 Transition Regulation Of Cell Growth Base-excision Repair Oxidized DNA Binding FHA Domain Binding FMN Adenylyltransferase Activity FAD Biosynthetic Process FAD Diphosphatase Activity Cellular Response To Glucose Starvation Regulation Of Telomere Maintenance Via Telomere Lengthening Response To Gamma Radiation Regulation Of DNA Metabolic Process Positive Regulation Of Myofibroblast Differentiation NAD+-protein-serine ADP-ribosyltransferase Activity DNA Repair