MED11 and CCDC120

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		MED11	CCDC120
Description		mediator complex subunit 11	coiled-coil domain containing 120
Image			No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleoplasm Mediator Complex Core Mediator Complex	Cytoplasm Endosome Centriole Cytoskeleton Growth Cone Cell Projection Neuron Projection Centriolar Subdistal Appendage
	Molecular Function	Transcription Coregulator Activity Protein Binding Ubiquitin Protein Ligase Activity	Protein Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Protein Ubiquitination Positive Regulation Of Transcription Elongation By RNA Polymerase II RNA Polymerase II Preinitiation Complex Assembly Positive Regulation Of Transcription Initiation By RNA Polymerase II	Intracellular Protein Localization Microtubule Anchoring At Centrosome
Pathways		PPARA activates gene expression Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation RSV-host interactions
Drugs
Diseases
GWAS
Interacting Genes		14 interacting genes: ABI2 APP CCDC120 CFTR GCSH MED22 MED8 MED9 NDEL1 NME7 SGF29 SSC5D SYCE2 USHBP1	103 interacting genes: AIRIM AKAP8L ARID5A ATP23 BCAS2 BLZF1 BRCA1 CADPS CALCOCO2 CCDC102B CCDC13 CCDC136 CCDC57 CCDC85B CDR2 CEP170P1 CEP55 CKS1B CNFN COG6 CTBP2 CYSRT1 CYTH2 DAZAP2 EFHC2 EIF3F FCHSD2 FOS FOSL1 FSD2 GOLGA2 GOLGA6L9 GPRASP3 HNRNPH1 HOMER3 HOXA1 HSF2BP IFT88 IHO1 INTS11 KASH5 KRT15 KRT31 KRT34 KRT35 KRT38 KRT40 KRTAP13-3 KRTAP19-1 KRTAP6-1 KRTAP6-2 KRTAP6-3 LMNA LMNB2 LMO4 LZTS1 MAGED1 MDFI MED11 METTL27 MID2 MIIP MIPOL1 MKRN3 MRPL38 MTUS2 MYOG NCK2 NEK6 NOTO NXF1 PKP2 PLA2G10 PLAGL2 PLEKHG4 POU2AF1 PRDM6 RABEP1 RBPMS RERE RINT1 RUSC1 SFI1 SMARCB1 SORBS3 SPAG8 STX11 TFIP11 TLE5 TP53BP1 TRAF1 TRIM42 TRIM55 TRIM63 TRIP6 TSC1 TSGA10IP USHBP1 ZDHHC17 ZIM2 ZMAT5 ZNF648 ZRANB1
Entrez ID		400569	90060
HPRD ID		14709	06595
Ensembl ID		ENSG00000161920	ENSG00000147144
Uniprot IDs		I3L3E8 Q9P086	Q96HB5
PDB IDs		7EMF 7ENA 7ENC 7ENJ 7LBM 7NVR 8GXQ 8GXS 8T9D 8TQW 8TRH
Enriched GO Terms of Interacting Partners?		Core Mediator Complex Mediator Complex RNA Polymerase II Preinitiation Complex Assembly Positive Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of Transcription Initiation By RNA Polymerase II Positive Regulation Of Transcription Elongation By RNA Polymerase II Transcription Preinitiation Complex Assembly Positive Regulation Of DNA-templated Transcription Initiation Regulation Of Transcription Initiation By RNA Polymerase II Regulation Of DNA-templated Transcription Initiation Regulation Of Transcription Elongation By RNA Polymerase II Regulation Of DNA-templated Transcription Elongation Transcription Coregulator Activity Transport Along Microtubule Protein-DNA Complex Assembly Cytoskeleton-dependent Intracellular Transport Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Microtubule-based Transport Amylin Binding Positive Regulation Of Toll Signaling Pathway Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Positive Regulation Of Gene Expression, Epigenetic Cellular Response To CAMP Acetylcholine Receptor Activator Activity PTB Domain Binding Cell Projection Morphogenesis Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Axo-dendritic Transport Endosome To Plasma Membrane Transport Vesicle Cellular Component Assembly Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Defense Response To Gram-negative Bacterium Positive Regulation Of G Protein-coupled Receptor Internalization Response To CAMP Positive Regulation Of Anion Channel Activity Positive Regulation Of Monoatomic Anion Transport PDZ Domain Binding Glycine Decarboxylation Via Glycine Cleavage System Glycine Cleavage Complex Aminomethyltransferase Activity	Intermediate Filament Protein Binding Identical Protein Binding Intermediate Filament Organization Structural Constituent Of Skin Epidermis Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Cytoskeleton Transcription Coactivator Activity Cytoskeleton Organization Keratin Filament Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Organelle Organization Structural Molecule Activity Structural Constituent Of Cytoskeleton Nuclear Pore Localization
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