FAM50B and TACC1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		FAM50B	TACC1
Description		family with sequence similarity 50 member B	transforming acidic coiled-coil containing protein 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Midbody Intercellular Bridge	Nucleus Cytoplasm Centrosome Cytosol Cytoskeleton Membrane Midbody
	Molecular Function	Protein Binding	Transcription Coactivator Activity Protein Binding Nuclear Receptor Binding Nuclear Estrogen Receptor Binding Nuclear Glucocorticoid Receptor Binding Nuclear Retinoic Acid Receptor Binding Peroxisome Proliferator Activated Receptor Binding Nuclear Retinoid X Receptor Binding Nuclear Thyroid Hormone Receptor Binding
	Biological Process	Chromatin Organization	Microtubule Cytoskeleton Organization Mitotic Spindle Organization Nuclear Migration Cerebral Cortex Development Positive Regulation Of DNA-templated Transcription Cell Division
Pathways
Drugs
Diseases
GWAS		Adverse response to chemotherapy (neutropenia/leucopenia) (camptothecin) ( 23648065)	Blond vs. brown/black hair color ( 30531825) Chronic mountain sickness ( 31417607) Midgestational circulating levels of PBDEs ( 28235828)
Interacting Genes		49 interacting genes: ACTN2 ADRA1A BICD2 CARD9 CCDC136 CCDC57 CCDC85B CCDC89 CCNC CDR2 DEUP1 FSD2 GFAP GMCL1 GOLGA2 GRIPAP1 HAP1 HOOK2 IKZF1 KASH5 KPNA3 KPNA4 KRT31 KRT34 LDOC1 LZTS1 LZTS2 MID1 MID2 MLH1 NUTF2 PAX6 PDE4DIP PIBF1 PSMB1 RABEP1 TACC1 TBC1D1 TFIP11 TRAF2 TRIM14 TRIM37 TRIM54 UBL5 VAC14 VPS52 WBP4 ZMYND12 ZRANB1	20 interacting genes: AURKA AURKB BTRC ERCC4 FAM50B HTT ITSN2 KAT2A KDM1A LSM7 MEMO1 SH2D4A SNRPG STX5 TDRD7 THAP12 THRA YEATS4 ZFHX3 ZNF48
Entrez ID		26240	6867
HPRD ID		16883	10391
Ensembl ID		ENSG00000145945	ENSG00000147526
Uniprot IDs		Q9Y247	B7Z3G3 E5RFM9 E7ET87 E7EVI4 O75410
PDB IDs
Enriched GO Terms of Interacting Partners?		Microtubule-based Process Cytoskeleton Organization Microtubule Cytoskeleton Organization Cytoskeleton Organelle Organization Cytoplasm Intracellular Protein Localization Protein Binding Protein Localization To Organelle Identical Protein Binding Nuclear Import Signal Receptor Activity Protein Transport Cellular Localization Intracellular Transport Spindle Organization Microtubule Organizing Center Organization Nuclear Pore Regulation Of Microtubule-based Process Centrosome Establishment Of Protein Localization Meiotic Telomere Clustering Chromosome Localization To Nuclear Envelope Involved In Homologous Chromosome Segregation Establishment Of Localization In Cell Telomere Localization Organelle Localization NLS-dependent Protein Nuclear Import Complex Protein Localization To Cytoskeleton Microtubule Microtubule Cytoskeleton Organization Involved In Mitosis Ubiquitin Protein Ligase Activity Spindle Midzone Assembly Cellular Component Assembly Protein Localization To Microtubule Microtubule Binding Positive Regulation Of Synaptic Transmission, GABAergic Enzyme Binding Negative Regulation Of Viral Transcription Membraneless Organelle Assembly Intermediate Filament Organization Regulation Of Microtubule Cytoskeleton Organization Transcription Coactivator Activity Positive Regulation Of Stress-activated MAPK Cascade Regulation Of Endocytic Recycling Regulation Of Viral Transcription Chromosome Localization Dynein Complex Binding Response To Muramyl Dipeptide	Spliceosomal Tri-snRNP Complex Chromosome Passenger Complex Nucleoplasm Nucleus Regulation Of DNA Metabolic Process Cellular Response To UV Regulation Of Microtubule-based Process U2-type Prespliceosome P Granule Cellular Response To Light Stimulus Microtubule Cytoskeleton Organization Involved In Mitosis U12-type Spliceosomal Complex Regulation Of Signal Transduction By P53 Class Mediator Spindle Midzone Protein Serine/threonine/tyrosine Kinase Activity Mitotic Cell Cycle Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Cellular Component Organization Response To UV Cellular Response To Radiation Regulation Of Cell Division Peptidyl-lysine Glutarylation Histone Glutaryltransferase Activity Histone Succinyltransferase Activity Regulation Of Protein Stability Peptide Glutaryltransferase Activity U4/U6 X U5 Tri-snRNP Complex Spindle Microtubule Mitotic Spindle Pole Positive Regulation Of Lateral Attachment Of Mitotic Spindle Microtubules To Kinetochore Negative Regulation Of Nucleobase-containing Compound Metabolic Process Midbody Negative Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Locomotor Rhythm Negative Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Nucleotide-excision Repair Involved In Interstrand Cross-link Repair Regulation Of Organelle Organization Regulation Of Centrosome Cycle Regulation Of DNA Repair Chromatin Organization Histone H3K9 Acetyltransferase Activity Protein Destabilization Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity U2-type Precatalytic Spliceosome Cell Cycle G2/M Phase Transition Negative Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly
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