GUCY1A3 and STUB1

Number of citations of the paper that reports this interaction (PMID 17873020)
9

Data Source:
HPRD (in vivo)

		GUCY1A3	STUB1
Gene Name		guanylate cyclase 1, soluble, alpha 3	STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Guanylate Cyclase Complex, Soluble	Ubiquitin Ligase Complex Nucleoplasm Cytoplasm Endoplasmic Reticulum Cytosol Plasma Membrane Ubiquitin Conjugating Enzyme Complex Nuclear Inclusion Body Intermediate Filament Cytoskeleton Extracellular Vesicular Exosome
	Molecular Function	Guanylate Cyclase Activity Receptor Activity GTP Binding Heme Binding	G-protein Coupled Receptor Binding Ubiquitin-protein Transferase Activity Protein Binding Ligase Activity Enzyme Binding Kinase Binding Hsp70 Protein Binding Protein Binding, Bridging TPR Domain Binding Ubiquitin Protein Ligase Binding Ubiquitin-ubiquitin Ligase Activity Protein Homodimerization Activity SMAD Binding Misfolded Protein Binding Hsp90 Protein Binding Ubiquitin Protein Ligase Activity
	Biological Process	CGMP Biosynthetic Process Nitric Oxide Mediated Signal Transduction Blood Coagulation Blood Circulation Regulation Of Blood Pressure Positive Regulation Of CGMP Biosynthetic Process Response To Defense-related Host Nitric Oxide Production Relaxation Of Vascular Smooth Muscle	Protein Polyubiquitination DNA Repair Ubiquitin-dependent Protein Catabolic Process Misfolded Or Incompletely Synthesized Protein Catabolic Process Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Ubiquitin-dependent SMAD Protein Catabolic Process Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Protein Ubiquitination Regulation Of Glucocorticoid Metabolic Process Negative Regulation Of Protein Binding Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Protein Maturation Protein Autoubiquitination Protein K63-linked Ubiquitination Cellular Response To Misfolded Protein Positive Regulation Of Chaperone-mediated Protein Complex Assembly
Pathways		Platelet homeostasis Nitric oxide stimulates guanylate cyclase	Loss of Function of TGFBR2 in Cancer TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Antigen processing: Ubiquitination & Proteasome degradation Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer SMAD2/3 MH2 Domain Mutants in Cancer Downregulation of TGF-beta receptor signaling TGFBR1 KD Mutants in Cancer TGF-beta receptor signaling activates SMADs TGFBR1 LBD Mutants in Cancer Loss of Function of TGFBR1 in Cancer Signaling by ERBB2 Signaling by TGF-beta Receptor Complex Signaling by TGF-beta Receptor Complex in Cancer Class I MHC mediated antigen processing & presentation SMAD4 MH2 Domain Mutants in Cancer Adaptive Immune System
Drugs
Diseases
GWAS		Blood pressure ( 21909110) Coronary heart disease ( 22751097) Diastolic blood pressure ( 21909115) Systolic blood pressure ( 21909115)
Protein-Protein Interactions		4 interactors: AGAP1 IKBKG MAPK8 STUB1	92 interactors: ABL1 ACD AHR AR ATCAY ATXN3 BAG1 BAG5 BCR BMPR1B CCL28 CTBP2 CYP2E1 CYP3A4 DAXX DNAJB1 DYX1C1 EIF5A ERBB2 ERN1 ESR1 FBXO2 FBXO27 FOXP3 GHR GPR37 GUCY1A2 GUCY1A3 HIF1A HSF1 HSP90AA1 HSPA1A HSPA1B HSPA4 HSPA8 IRF1 JOSD1 JOSD2 KHDRBS1 KIAA1524 MAP3K11 MAP3K2 MAPT MCF2 MITF MPP1 MST1R MYOCD NOS1 NQO1 OLFM3 PARK2 PFN1 POLB POT1 PRKCZ PSMA3 PSMD4 RAF1 RUNX1 RUNX2 RUSC1 S100A2 S100P SIRT6 SMAD1 SMAD2 SMAD3 SMAD4 SMG5 SMURF1 SRC TAL1 TERF1 TGFBR1 TINF2 TRAF6 TXN2 UBB UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E2 UBE2E3 UBE2L3 UBE2N UBE2Q1 UBE2V1 UBE2W VCP XIAP
Entrez ID		2982	10273
HPRD ID		00768	06232
Ensembl ID		ENSG00000164116	ENSG00000103266
Uniprot IDs		B3KU69 Q02108	Q9UNE7
PDB IDs		3UVJ
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Catalytic Activity Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Negative Regulation Of Protein Binding Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor 4 Signaling Pathway JNK Cascade Negative Regulation Of Binding Regulation Of Catalytic Activity Toll-like Receptor Signaling Pathway Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Regulation Of Signal Transduction Activation Of Innate Immune Response Regulation Of Protein Binding Regulation Of Signaling Positive Regulation Of Chaperone-mediated Protein Complex Assembly Positive Regulation Of Innate Immune Response Positive Regulation Of Metabolic Process MAPK Cascade Fc-epsilon Receptor Signaling Pathway Regulation Of Innate Immune Response Regulation Of Binding Fc Receptor Signaling Pathway JUN Phosphorylation Signal Transduction By Phosphorylation Positive Regulation Of Deacetylase Activity Cellular Response To Stress Ubiquitin-dependent SMAD Protein Catabolic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Determination Of Dorsal Identity Immune Response-regulating Cell Surface Receptor Signaling Pathway Intracellular Signal Transduction Regulation Of Glucocorticoid Metabolic Process Cellular Response To Nitric Oxide Regulation Of Cellular Protein Metabolic Process Immune Response-regulating Signaling Pathway Misfolded Or Incompletely Synthesized Protein Catabolic Process Cellular Response To Misfolded Protein Signal Transduction Response To Nitric Oxide	Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Response To Organic Substance Regulation Of Metabolic Process Cellular Response To Stimulus Protein Polyubiquitination Response To Stress Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Signal Transduction Regulation Of Cellular Protein Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Protein Ubiquitination Regulation Of Cell Proliferation Regulation Of Protein Metabolic Process Response To Stimulus Cellular Metabolic Process Regulation Of Signal Transduction Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Cellular Response To Organic Substance Positive Regulation Of Protein Modification Process Positive Regulation Of Gene Expression Cellular Response To Stress Regulation Of Signaling Positive Regulation Of Transferase Activity Regulation Of Catalytic Activity Cellular Response To Growth Factor Stimulus Positive Regulation Of Catalytic Activity Regulation Of Cell Death Protein Ubiquitination Response To Growth Factor Regulation Of Cellular Component Organization Protein Modification By Small Protein Conjugation Cellular Protein Metabolic Process Regulation Of Cellular Process Cell Communication Positive Regulation Of Transcription, DNA-templated Cellular Protein Modification Process Regulation Of Apoptotic Process Regulation Of Immune System Process Signaling Cell Death Death Cellular Nitrogen Compound Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Negative Regulation Of Cell Death Negative Regulation Of Protein Metabolic Process Protein Metabolic Process
Tagcloud ?		2j 6j buffer bxd coexpression congruent crosses dba distal extraordinary fluctuation gaba gabra1 gabra2 gabrb2 gabrb3 gabrg2 heritable massive naaa neurotransmission nos1 platforms remarkably subunits unlinked utrs zkscan1	atg5 atg7 autophagic autophagosomes autophagy beclin chaperone degradation degraded delta133p53alpha downregulated e3 full identifies isoform knockdown ligase orchestrates passage proliferating replicative replicatively restores reveals senescence senescent sirna turnover unlike
Tagcloud (Difference) ?		2j 6j buffer bxd coexpression congruent crosses dba distal extraordinary fluctuation gaba gabra1 gabra2 gabrb2 gabrb3 gabrg2 heritable massive naaa neurotransmission nos1 platforms remarkably subunits unlinked utrs zkscan1	atg5 atg7 autophagic autophagosomes autophagy beclin chaperone degradation degraded delta133p53alpha downregulated e3 full identifies isoform knockdown ligase orchestrates passage proliferating replicative replicatively restores reveals senescence senescent sirna turnover unlike
Tagcloud (Intersection) ?