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GUCY1A3 and AGAP1
Number of citations of the paper that reports this interaction (PMID
15381706
)
7
Data Source:
HPRD
(in vivo, two hybrid)
GUCY1A3
AGAP1
Gene Name
guanylate cyclase 1, soluble, alpha 3
ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Guanylate Cyclase Complex, Soluble
Cytoplasm
Molecular Function
Guanylate Cyclase Activity
Receptor Activity
GTP Binding
Heme Binding
GTP Binding
Phospholipid Binding
ARF GTPase Activator Activity
Zinc Ion Binding
Biological Process
CGMP Biosynthetic Process
Nitric Oxide Mediated Signal Transduction
Blood Coagulation
Blood Circulation
Regulation Of Blood Pressure
Positive Regulation Of CGMP Biosynthetic Process
Response To Defense-related Host Nitric Oxide Production
Relaxation Of Vascular Smooth Muscle
Small GTPase Mediated Signal Transduction
Protein Transport
Regulation Of ARF GTPase Activity
Positive Regulation Of GTPase Activity
Pathways
Platelet homeostasis
Nitric oxide stimulates guanylate cyclase
Drugs
Diseases
GWAS
Blood pressure (
21909110
)
Coronary heart disease (
22751097
)
Diastolic blood pressure (
21909115
)
Systolic blood pressure (
21909115
)
Menarche (age at onset) (
23667675
)
Protein-Protein Interactions
4 interactors:
AGAP1
IKBKG
MAPK8
STUB1
6 interactors:
APP
GRB7
GUCY1A3
GUCY1B3
SMN1
TK1
Entrez ID
2982
116987
HPRD ID
00768
16359
Ensembl ID
ENSG00000164116
ENSG00000157985
Uniprot IDs
B3KU69
Q02108
B2RZG9
Q9UPQ3
PDB IDs
3UVJ
Enriched GO Terms of Interacting Partners
?
Positive Regulation Of Catalytic Activity
Toll-like Receptor 5 Signaling Pathway
Toll-like Receptor 10 Signaling Pathway
Negative Regulation Of Protein Binding
Toll-like Receptor TLR6:TLR2 Signaling Pathway
Toll-like Receptor TLR1:TLR2 Signaling Pathway
Toll-like Receptor 2 Signaling Pathway
Toll-like Receptor 9 Signaling Pathway
TRIF-dependent Toll-like Receptor Signaling Pathway
MyD88-independent Toll-like Receptor Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
MyD88-dependent Toll-like Receptor Signaling Pathway
Toll-like Receptor 4 Signaling Pathway
JNK Cascade
Negative Regulation Of Binding
Regulation Of Catalytic Activity
Toll-like Receptor Signaling Pathway
Stress-activated MAPK Cascade
Stress-activated Protein Kinase Signaling Cascade
Pattern Recognition Receptor Signaling Pathway
Innate Immune Response-activating Signal Transduction
Regulation Of Signal Transduction
Activation Of Innate Immune Response
Regulation Of Protein Binding
Regulation Of Signaling
Positive Regulation Of Chaperone-mediated Protein Complex Assembly
Positive Regulation Of Innate Immune Response
Positive Regulation Of Metabolic Process
MAPK Cascade
Fc-epsilon Receptor Signaling Pathway
Regulation Of Innate Immune Response
Regulation Of Binding
Fc Receptor Signaling Pathway
JUN Phosphorylation
Signal Transduction By Phosphorylation
Positive Regulation Of Deacetylase Activity
Cellular Response To Stress
Ubiquitin-dependent SMAD Protein Catabolic Process
Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Positive Regulation Of Determination Of Dorsal Identity
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Intracellular Signal Transduction
Regulation Of Glucocorticoid Metabolic Process
Cellular Response To Nitric Oxide
Regulation Of Cellular Protein Metabolic Process
Immune Response-regulating Signaling Pathway
Misfolded Or Incompletely Synthesized Protein Catabolic Process
Cellular Response To Misfolded Protein
Signal Transduction
Response To Nitric Oxide
Blood Coagulation
Hemostasis
Regulation Of Body Fluid Levels
Wound Healing
Nitric Oxide Mediated Signal Transduction
CGMP Biosynthetic Process
Response To Wounding
CGMP Metabolic Process
Cyclic Purine Nucleotide Metabolic Process
Nucleotide Biosynthetic Process
Cyclic Nucleotide Biosynthetic Process
Cyclic Nucleotide Metabolic Process
Nucleotide Metabolic Process
Fetal Process Involved In Parturition
Nucleobase-containing Small Molecule Metabolic Process
Response To Defense-related Host Nitric Oxide Production
Skeletal Muscle Cell Proliferation
Synaptic Growth At Neuromuscular Junction
Second-messenger-mediated Signaling
Cellular Component Assembly
Collateral Sprouting In Absence Of Injury
Purine Nucleotide Biosynthetic Process
Ribose Phosphate Biosynthetic Process
Ribonucleoprotein Complex Assembly
Collateral Sprouting
Axon Midline Choice Point Recognition
Small Molecule Metabolic Process
Nucleobase-containing Compound Metabolic Process
Smooth Endoplasmic Reticulum Calcium Ion Homeostasis
Response To Cortisol
Thymidine Metabolic Process
Organophosphate Metabolic Process
Response To Host Immune Response
Axon Choice Point Recognition
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Deoxyribonucleoside Monophosphate Biosynthetic Process
Regulation Of Translation
Relaxation Of Vascular Smooth Muscle
Cellular Nitrogen Compound Metabolic Process
Ribonucleotide Metabolic Process
Neuron Remodeling
Relaxation Of Smooth Muscle
Pyrimidine Nucleoside Salvage
Pyrimidine-containing Compound Salvage
Purine Nucleotide Metabolic Process
Blood Circulation
Ribose Phosphate Metabolic Process
Phosphate-containing Compound Metabolic Process
Ribonucleoprotein Complex Biogenesis
Tagcloud
?
2j
6j
buffer
bxd
coexpression
congruent
crosses
dba
distal
extraordinary
fluctuation
gaba
gabra1
gabra2
gabrb2
gabrb3
gabrg2
heritable
massive
naaa
neurotransmission
nos1
platforms
remarkably
subunits
unlinked
utrs
zkscan1
Tagcloud (Difference)
?
2j
6j
buffer
bxd
coexpression
congruent
crosses
dba
distal
extraordinary
fluctuation
gaba
gabra1
gabra2
gabrb2
gabrb3
gabrg2
heritable
massive
naaa
neurotransmission
nos1
platforms
remarkably
subunits
unlinked
utrs
zkscan1
Tagcloud (Intersection)
?