GUCA2A and GJA8

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		GUCA2A	GJA8
Description		guanylate cyclase activator 2A	gap junction protein alpha 8
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region	Plasma Membrane Gap Junction Connexin Complex Membrane Anchoring Junction
	Molecular Function	Hormone Activity Protein Binding Guanylate Cyclase Activator Activity	Gap Junction Channel Activity Protein Binding
	Biological Process	Signal Transduction	Lens Development In Camera-type Eye Cell Communication Cell-cell Signaling Camera-type Eye Development Transmembrane Transport Gap Junction-mediated Intercellular Transport
Pathways		Digestion	Gap junction assembly
Drugs
Diseases
GWAS			Retinopathy x type 2 diabetes interaction ( 32541925) Triglyceride levels ( 34074324)
Interacting Genes		15 interacting genes: ASPH FFAR2 GJA8 GOLM1 GUCY2C NEMP1 SGTA SLC34A2 TMEM179B TMEM237 TMEM31 TMEM86B TRAM1 UBQLN1 UBQLN2	125 interacting genes: ABL1 ACKR2 APOA2 APOD APOL3 AQP4 ARL6IP6 ATP6V0B C1GALT1 C2CD2L C3orf52 CCDC167 CCL4 CD53 CIAO2A CLDN19 CLDN4 CLEC1A CLN6 COX20 CTXN3 CXCL16 CYBC1 CYP4F2 DEFB121 DOLK ERMP1 FDFT1 FXYD6 GIMAP1 GIMAP5 GJB2 GPR108 GPR151 GPR61 GUCA2A IGFBP5 INSIG2 ITGAM KIR2DL3 LAPTM4B LAT LEPROTL1 LHFPL5 MAL MALL MARCHF2 MFSD11 MFSD6 MGST2 MIP MS4A13 NINJ2 ORMDL2 OTOP2 P2RY13 PGAP2 PLN PLP1 PMP22 PNLIPRP1 PRAF2 PROKR2 PTPRN QRFPR REEP6 RNF152 RUSF1 RXFP4 S1PR5 SCARF1 SEC22B SEC22C SEC23A SFTPC SLC13A2 SLC13A5 SLC16A12 SLC16A13 SLC16A3 SLC30A3 SLC35A4 SLC35F1 SLC35F6 SLC38A4 SLC38A7 SLC39A2 SLC39A7 SLC39A9 SLC52A1 SLC66A1 SLC66A2 SLC8A3 SMCO4 SMIM1 STX1B STX8 THSD7B TJP1 TMBIM6 TMEM100 TMEM107 TMEM121 TMEM128 TMEM147 TMEM182 TMEM239 TMEM242 TMEM243 TMEM42 TMEM45A TMEM60 TMEM65 TMEM72 TMEM86B TMEM97 TSPAN33 TWSG1 UBXN8 UNC93A UPK1B VAMP5 VAPB YIF1A YIPF6
Entrez ID		2980	2703
HPRD ID		00767	02939
Ensembl ID		ENSG00000197273	ENSG00000121634
Uniprot IDs		Q02747	P48165 X5D7G1
PDB IDs		1GNA 1GNB 1O8R
Enriched GO Terms of Interacting Partners?		Membrane Positive Regulation Of ERAD Pathway Regulation Of ERAD Pathway Positive Regulation Of Response To Endoplasmic Reticulum Stress Positive Regulation Of Proteolysis Regulation Of Response To Endoplasmic Reticulum Stress ERAD Pathway Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Proteolysis Protein Insertion Into ER Membrane Polyubiquitin Modification-dependent Protein Binding Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Negative Regulation Of Store-operated Calcium Channel Activity D-lysine 5,6-aminomutase Activity Response To Endoplasmic Reticulum Stress Peptidyl-aspartic Acid 3-dioxygenase Activity Plasma Membrane Positive Regulation Of Acute Inflammatory Response To Non-antigenic Stimulus Protein Targeting To Membrane TRC Complex Protein Insertion Into Membrane Negative Regulation Of G Protein-coupled Receptor Internalization Ether Hydrolase Activity Alkenylglycerophosphocholine Hydrolase Activity Regulation Of Transmembrane Transporter Activity Regulation Of Monoatomic Ion Transmembrane Transporter Activity Autophagosome Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Autophagosome Assembly	Membrane Protein Binding Plasma Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Transmembrane Transport Zinc Ion Transmembrane Transporter Activity Carboxylic Acid Transmembrane Transport Organic Acid Transmembrane Transport Zinc Ion Transmembrane Transport Structural Constituent Of Myelin Sheath Zinc Ion Transport Transmembrane Transporter Activity Fumarate Transport Carboxylic Acid Transport Organic Acid Transport Sodium:dicarboxylate Symporter Activity Chemical Homeostasis Organic Anion Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Homeostatic Process Cholesterol Binding Metal Ion Transmembrane Transporter Activity Succinate Transmembrane Transporter Activity Succinate Transport Succinate Transmembrane Transport COPII-coated Vesicle Budding
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