GUCA2A and TRAM1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		GUCA2A	TRAM1
Description		guanylate cyclase activator 2A	translocation associated membrane protein 1
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Hormone Activity Protein Binding Guanylate Cyclase Activator Activity	Protein Binding Signaling Receptor Activity
	Biological Process	Signal Transduction	Cotranslational Protein Targeting To Membrane SRP-dependent Cotranslational Protein Targeting To Membrane, Translocation Response To Unfolded Protein Protein Transport Protein Insertion Into ER Membrane
Pathways		Digestion	SRP-dependent cotranslational protein targeting to membrane
Drugs
Diseases
GWAS			Cardiac Troponin-T levels ( 23247143) Erythrocyte cadmium concentration in never smokers ( 27005419) Refractive error ( 32231278) Spherical equivalent or myopia (age of diagnosis) ( 29808027)
Interacting Genes		15 interacting genes: ASPH FFAR2 GJA8 GOLM1 GUCY2C NEMP1 SGTA SLC34A2 TMEM179B TMEM237 TMEM31 TMEM86B TRAM1 UBQLN1 UBQLN2	12 interacting genes: APP CREB3 DRD2 ESR1 ESR2 GUCA2A SEC61B TICAM1 TIRAP TRAF6 UBC VKORC1
Entrez ID		2980	23471
HPRD ID		00767	05545
Ensembl ID		ENSG00000197273	ENSG00000067167
Uniprot IDs		Q02747	G3XAN4 Q15629 Q6FHL3
PDB IDs		1GNA 1GNB 1O8R
Enriched GO Terms of Interacting Partners?		Membrane Positive Regulation Of ERAD Pathway Regulation Of ERAD Pathway Positive Regulation Of Response To Endoplasmic Reticulum Stress Positive Regulation Of Proteolysis Regulation Of Response To Endoplasmic Reticulum Stress ERAD Pathway Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Proteolysis Protein Insertion Into ER Membrane Polyubiquitin Modification-dependent Protein Binding Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Negative Regulation Of Store-operated Calcium Channel Activity D-lysine 5,6-aminomutase Activity Response To Endoplasmic Reticulum Stress Peptidyl-aspartic Acid 3-dioxygenase Activity Plasma Membrane Positive Regulation Of Acute Inflammatory Response To Non-antigenic Stimulus Protein Targeting To Membrane TRC Complex Protein Insertion Into Membrane Negative Regulation Of G Protein-coupled Receptor Internalization Ether Hydrolase Activity Alkenylglycerophosphocholine Hydrolase Activity Regulation Of Transmembrane Transporter Activity Regulation Of Monoatomic Ion Transmembrane Transporter Activity Autophagosome Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Autophagosome Assembly	Positive Regulation Of Interleukin-6 Production Regulation Of Innate Immune Response Cellular Response To Oxygen-containing Compound Positive Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Interleukin-6 Production Positive Regulation Of Nitric Oxide Metabolic Process Nuclear Estrogen Receptor Activity Toll-like Receptor 4 Signaling Pathway Cell Surface Toll-like Receptor Signaling Pathway Toll-like Receptor Signaling Pathway Cell Surface Pattern Recognition Receptor Signaling Pathway Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Nitric Oxide Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Lipid Response To Lipid Regulation Of Defense Response Positive Regulation Of Chemokine Production Positive Regulation Of Biosynthetic Process Intracellular Receptor Signaling Pathway Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Cytokine Production Signaling Adaptor Activity Estrogen Response Element Binding TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of Immune Response Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Positive Regulation Of Leukocyte Chemotaxis MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Regulation Of Chemokine Production Positive Regulation Of JNK Cascade Regulation Of Immune System Process MyD88-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Macromolecule Metabolic Process Regulation Of Cell Population Proliferation Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Response To Estradiol Positive Regulation Of DNA-binding Transcription Factor Activity Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Neurotransmitter Uptake Myeloid Leukocyte Activation Regulation Of Type I Interferon Production Nuclear Steroid Receptor Activity Intracellular Signal Transduction Positive Regulation Of Long-term Synaptic Potentiation
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?