ERCC3 and RAD52

Number of citations of the paper that reports this interaction (PubMedID 12372413)
0

Data Source:
HPRD (in vivo)

		ERCC3	RAD52
Description		ERCC excision repair 3, TFIIH core complex helicase subunit	RAD52 DNA repair protein
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GO Annotations	Cellular Component	Nucleotide-excision Repair Factor 3 Complex Transcription Factor TFIIH Core Complex Nucleus Nucleoplasm Transcription Factor TFIID Complex Transcription Factor TFIIH Holo Complex Transcription Preinitiation Complex	Nucleus Nucleoplasm Protein-containing Complex Protein-DNA Complex
	Molecular Function	Nucleotide Binding DNA Binding DNA Helicase Activity Damaged DNA Binding Helicase Activity Protein Binding ATP Binding Hydrolase Activity Isomerase Activity ATP Hydrolysis Activity 3'-5' DNA Helicase Activity Promoter-specific Chromatin Binding	DNA Binding Single-stranded DNA Binding Protein Binding Identical Protein Binding
	Biological Process	DNA Topological Change DNA Repair Transcription-coupled Nucleotide-excision Repair Nucleotide-excision Repair Transcription By RNA Polymerase II Transcription Initiation At RNA Polymerase II Promoter Transcription Elongation By RNA Polymerase II Apoptotic Process DNA Damage Response Response To Oxidative Stress Intracellular Protein Localization Response To UV UV Protection Hair Cell Differentiation Positive Regulation Of Apoptotic Process Embryonic Organ Development Regulation Of Mitotic Cell Cycle Phase Transition	Double-strand Break Repair Via Homologous Recombination DNA Recombinase Assembly DNA Repair Double-strand Break Repair DNA Recombination Mitotic Recombination DNA Damage Response DNA Double-strand Break Processing Involved In Repair Via Single-strand Annealing Cellular Response To Oxidative Stress Double-strand Break Repair Via Single-strand Annealing Regulation Of Nucleotide-excision Repair
Pathways		Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex RNA Pol II CTD phosphorylation and interaction with CE during HIV infection HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome Formation of HIV-1 elongation complex containing HIV-1 Tat Tat-mediated elongation of the HIV-1 transcript NoRC negatively regulates rRNA expression Formation of Incision Complex in GG-NER Dual Incision in GG-NER RNA Polymerase II Pre-transcription Events Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER TP53 Regulates Transcription of DNA Repair Genes mRNA Capping RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase I Transcription Termination RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Elongation RNA Polymerase II Transcription Initiation And Promoter Clearance RNA Pol II CTD phosphorylation and interaction with CE	SUMOylation of DNA damage response and repair proteins HDR through Single Strand Annealing (SSA) HDR through MMEJ (alt-NHEJ)
Drugs
Diseases		Disorders of nucleotide excision repair, including: Xeroderma pigmentosum (XP); Cockayne syndrome (CS); UV-sensitive syndrome (UVS); Trichothiodystrophy (TTD); Cerebro-oculo-facio-skeletal syndrome (COFS); XFE progeroid syndrome
GWAS			Body mass index ( 26426971) Eosinophil percentage of granulocytes ( 27863252) Femur bone mineral density x serum urate levels interaction ( 34046847) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) Lung cancer ( 22899653) Neutrophil percentage of granulocytes ( 27863252) Small cell lung carcinoma ( 28604730) Systolic blood pressure ( 30224653 30578418) Youthful appearance (self-reported) ( 32339537)
Interacting Genes		38 interacting genes: ADAMTSL4 AR BCR BLZF1 CCNC CCNH CDC42 CDK7 CDK8 CEP70 CEP76 E2F1 ERCC2 GOLGA2 GTF2E1 GTF2E2 GTF2H1 GTF2H2 GTF2H3 GTF2H4 GTF2H5 KPNA3 MAGED1 MCF2 MNAT1 MSANTD2 PSMC5 RAD52 ROPN1 SNW1 SRPK2 TP53 TRIM14 TRIM27 TUBG1 XIAP XPC ZSCAN1	25 interacting genes: ABL1 AURKB DCP1A ERCC1 ERCC2 ERCC3 ERCC4 KPNA3 KPNA5 MCM2 MCM3 MEOX1 MEOX2 NFYC PAX5 PLK3 RAD51 RDM1 RPA1 RPA2 SEM1 SUMO1 TTK UBE2I WRN
Entrez ID		2071	5893
HPRD ID		00593	11855
Ensembl ID		ENSG00000163161	ENSG00000002016
Uniprot IDs		B3KRG2 B3KTH1 P19447	B7Z2G8 B7Z5Q6 F5GX32 P43351 Q5DR82
PDB IDs		4ERN 5IVW 5IY6 5IY7 5IY8 5IY9 5OF4 6NMI 6O9L 6O9M 6RO4 7AD8 7EGB 7EGC 7ENA 7ENC 7LBM 7NVR 7NVV 7NVW 7NVX 7NVY 7NVZ 7NW0 8BVW 8BYQ 8EBS 8EBT 8EBU 8EBV 8EBW 8EBX 8EBY 8GXQ 8GXS 8WAK 8WAL 8WAN 8WAO 8WAP 8WAQ 8WAR 8WAS	1H2I 1KN0 5JRB 5XRZ 5XS0 8BJM 8H1P 8RIL 8RJ3 8RJW 8TKQ
Enriched GO Terms of Interacting Partners?		Transcription Factor TFIIH Core Complex Transcription Factor TFIIH Holo Complex Transcription Initiation At RNA Polymerase II Promoter Nucleotide-excision Repair DNA-templated Transcription Initiation Transcription Factor TFIID Complex DNA-templated Transcription CAK-ERCC2 Complex RNA Polymerase II General Transcription Initiation Factor Activity DNA Damage Response Transcription By RNA Polymerase II Nucleobase-containing Compound Biosynthetic Process Transcription Factor TFIIK Complex DNA Repair Core TFIIH Complex Portion Of Holo TFIIH Complex RNA Metabolic Process Nucleoplasm Cyclin-dependent Protein Kinase Holoenzyme Complex Nucleic Acid Metabolic Process Nucleus Regulation Of Cell Cycle DNA Metabolic Process Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Cellular Response To Stress Transcription Factor TFIIE Complex Regulation Of Nucleobase-containing Compound Metabolic Process Macromolecule Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Process Regulation Of G1/S Transition Of Mitotic Cell Cycle Protein-containing Complex Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Primary Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process CKM Complex Regulation Of Cell Cycle Phase Transition Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of Nucleobase-containing Compound Metabolic Process Signal Transduction By P53 Class Mediator Positive Regulation Of Biosynthetic Process Positive Regulation Of RNA Metabolic Process Transcription Elongation By RNA Polymerase I Regulation Of Macromolecule Biosynthetic Process	DNA Repair DNA Damage Response DNA Metabolic Process Nucleus Double-strand Break Repair Recombinational Repair Double-strand Break Repair Via Homologous Recombination DNA Recombination Chromosome, Telomeric Region Nucleotide-excision Repair Single-stranded DNA Binding Damaged DNA Binding Regulation Of DNA Metabolic Process DNA Binding UV Protection Nucleoplasm Cellular Response To Stress Telomere Maintenance Protein Localization To Organelle PML Body Nucleic Acid Metabolic Process Chromosome Organization Telomere Organization Mismatch Repair Response To UV Response To Radiation DNA Helicase Activity Nucleobase-containing Compound Metabolic Process 3'-5' DNA Helicase Activity Regulation Of Nucleobase-containing Compound Metabolic Process Telomere Maintenance Via Recombination Helicase Activity ATP Binding DNA Replication Repair Of Mitotic Kinetochore Microtubule Attachment Defect DNA Conformation Change Single-stranded DNA Helicase Activity Regulation Of Cell Cycle Phase Transition Mitotic Recombination Cellular Response To Radiation Regulation Of Mitotic Cell Cycle Telomeric DNA-containing Double Minutes Formation Nucleotide-excision Repair Factor 1 Complex Response To Light Stimulus Negative Regulation Of Protection From Non-homologous End Joining At Telomere Macromolecule Metabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Mitotic Cell Cycle Nucleotide Binding Response To Oxidative Stress
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