ERCC3 and BCR

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro, in vivo)

		ERCC3	BCR
Description		ERCC excision repair 3, TFIIH core complex helicase subunit	BCR activator of RhoGEF and GTPase
Image
GO Annotations	Cellular Component	Nucleotide-excision Repair Factor 3 Complex Transcription Factor TFIIH Core Complex Nucleus Nucleoplasm Transcription Factor TFIID Complex Transcription Factor TFIIH Holo Complex Transcription Preinitiation Complex	Cytosol Plasma Membrane Postsynaptic Density Membrane Axon Protein-containing Complex Cell Projection Dendritic Spine Synapse Extracellular Exosome Schaffer Collateral - CA1 Synapse Glutamatergic Synapse
	Molecular Function	Nucleotide Binding DNA Binding DNA Helicase Activity Damaged DNA Binding Helicase Activity Protein Binding ATP Binding Hydrolase Activity Isomerase Activity ATP Hydrolysis Activity 3'-5' DNA Helicase Activity Promoter-specific Chromatin Binding	Nucleotide Binding Protein Serine/threonine Kinase Activity Protein Tyrosine Kinase Activity Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity
	Biological Process	DNA Topological Change DNA Repair Transcription-coupled Nucleotide-excision Repair Nucleotide-excision Repair Transcription By RNA Polymerase II Transcription Initiation At RNA Polymerase II Promoter Transcription Elongation By RNA Polymerase II Apoptotic Process DNA Damage Response Response To Oxidative Stress Intracellular Protein Localization Response To UV UV Protection Hair Cell Differentiation Positive Regulation Of Apoptotic Process Embryonic Organ Development Regulation Of Mitotic Cell Cycle Phase Transition	Negative Regulation Of Cellular Extravasation Renal System Process Protein Phosphorylation Phagocytosis Signal Transduction Small GTPase-mediated Signal Transduction Brain Development Cell Migration Actin Cytoskeleton Organization Keratinocyte Differentiation Response To Lipopolysaccharide Regulation Of Rho Protein Signal Transduction Intracellular Signal Transduction Inner Ear Morphogenesis Regulation Of Vascular Permeability Neutrophil Degranulation Negative Regulation Of Neutrophil Degranulation Focal Adhesion Assembly Homeostasis Of Number Of Cells Negative Regulation Of Inflammatory Response Positive Regulation Of Phagocytosis Modulation Of Chemical Synaptic Transmission Neuromuscular Process Controlling Balance Regulation Of Small GTPase Mediated Signal Transduction Establishment Of Localization In Cell Regulation Of Cell Cycle Definitive Hemopoiesis Negative Regulation Of Respiratory Burst Negative Regulation Of Blood Vessel Remodeling Intracellular Protein Transmembrane Transport Cellular Response To Lipopolysaccharide Activation Of GTPase Activity Macrophage Migration Negative Regulation Of Macrophage Migration Negative Regulation Of Reactive Oxygen Species Metabolic Process
Pathways		Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex RNA Pol II CTD phosphorylation and interaction with CE during HIV infection HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome Formation of HIV-1 elongation complex containing HIV-1 Tat Tat-mediated elongation of the HIV-1 transcript NoRC negatively regulates rRNA expression Formation of Incision Complex in GG-NER Dual Incision in GG-NER RNA Polymerase II Pre-transcription Events Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER TP53 Regulates Transcription of DNA Repair Genes mRNA Capping RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase I Transcription Termination RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Elongation RNA Polymerase II Transcription Initiation And Promoter Clearance RNA Pol II CTD phosphorylation and interaction with CE	Signaling by cytosolic FGFR1 fusion mutants Signaling by FGFR1 in disease RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RAC3 GTPase cycle
Drugs			Imatinib Dasatinib Bosutinib Ponatinib
Diseases		Disorders of nucleotide excision repair, including: Xeroderma pigmentosum (XP); Cockayne syndrome (CS); UV-sensitive syndrome (UVS); Trichothiodystrophy (TTD); Cerebro-oculo-facio-skeletal syndrome (COFS); XFE progeroid syndrome	Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Chronic myeloid leukemia (CML)
GWAS			Asthma ( 27611488) Coenzyme Q10 levels ( 27149984) Height ( 18391951) Immune response to smallpox vaccine (IL-6) ( 22542470) Kidney stones ( 31729369) Left-handedness ( 32989287)
Interacting Genes		38 interacting genes: ADAMTSL4 AR BCR BLZF1 CCNC CCNH CDC42 CDK7 CDK8 CEP70 CEP76 E2F1 ERCC2 GOLGA2 GTF2E1 GTF2E2 GTF2H1 GTF2H2 GTF2H3 GTF2H4 GTF2H5 KPNA3 MAGED1 MCF2 MNAT1 MSANTD2 PSMC5 RAD52 ROPN1 SNW1 SRPK2 TP53 TRIM14 TRIM27 TUBG1 XIAP XPC ZSCAN1	44 interacting genes: ABL1 ABL2 AFDN APBA3 BLK CBL CDC42 CRK CRKL DLG1 DOK1 ERCC3 FES GRB10 GRB2 HCK HNF1A IGSF21 IRS1 JAK2 LNX1 MAP4K5 PLCG1 PTPN1 PTPN11 PTPN6 RAD51 RASA1 RHOA SFN SHC1 SRC STUB1 TP53 TSG101 UBC UNC119 VAV1 YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ
Entrez ID		2071	613
HPRD ID		00593	01044
Ensembl ID		ENSG00000163161	ENSG00000186716
Uniprot IDs		B3KRG2 B3KTH1 P19447	P11274
PDB IDs		4ERN 5IVW 5IY6 5IY7 5IY8 5IY9 5OF4 6NMI 6O9L 6O9M 6RO4 7AD8 7EGB 7EGC 7ENA 7ENC 7LBM 7NVR 7NVV 7NVW 7NVX 7NVY 7NVZ 7NW0 8BVW 8BYQ 8EBS 8EBT 8EBU 8EBV 8EBW 8EBX 8EBY 8GXQ 8GXS 8WAK 8WAL 8WAN 8WAO 8WAP 8WAQ 8WAR 8WAS	1K1F 2AIN 5N6R 5N7E 5OC7
Enriched GO Terms of Interacting Partners?		Transcription Factor TFIIH Core Complex Transcription Factor TFIIH Holo Complex Transcription Initiation At RNA Polymerase II Promoter Nucleotide-excision Repair DNA-templated Transcription Initiation Transcription Factor TFIID Complex DNA-templated Transcription CAK-ERCC2 Complex RNA Polymerase II General Transcription Initiation Factor Activity DNA Damage Response Transcription By RNA Polymerase II Nucleobase-containing Compound Biosynthetic Process Transcription Factor TFIIK Complex DNA Repair Core TFIIH Complex Portion Of Holo TFIIH Complex RNA Metabolic Process Nucleoplasm Cyclin-dependent Protein Kinase Holoenzyme Complex Nucleic Acid Metabolic Process Nucleus Regulation Of Cell Cycle DNA Metabolic Process Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Cellular Response To Stress Transcription Factor TFIIE Complex Regulation Of Nucleobase-containing Compound Metabolic Process Macromolecule Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Process Regulation Of G1/S Transition Of Mitotic Cell Cycle Protein-containing Complex Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Primary Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process CKM Complex Regulation Of Cell Cycle Phase Transition Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of Nucleobase-containing Compound Metabolic Process Signal Transduction By P53 Class Mediator Positive Regulation Of Biosynthetic Process Positive Regulation Of RNA Metabolic Process Transcription Elongation By RNA Polymerase I Regulation Of Macromolecule Biosynthetic Process	Phosphotyrosine Residue Binding Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Intracellular Signal Transduction Enzyme-linked Receptor Protein Signaling Pathway Cytosol Regulation Of Cell Adhesion Signal Transduction Intracellular Signaling Cassette Cytoplasm Regulation Of Transport Ephrin Receptor Binding Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Adhesion Receptor Tyrosine Kinase Binding Regulation Of Intracellular Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Enzyme Binding Non-membrane Spanning Protein Tyrosine Kinase Activity ERBB Signaling Pathway Focal Adhesion Regulation Of Immune System Process Peptidyl-tyrosine Phosphorylation Protein Kinase Binding Regulation Of Immune Response Regulation Of Signal Transduction Negative Regulation Of Signaling Negative Regulation Of Cell Communication Protein Domain Specific Binding Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Cell-cell Adhesion Cadherin Binding Regulation Of Protein Localization Insulin-like Growth Factor Receptor Binding Negative Regulation Of Signal Transduction Regulation Of Protein-containing Complex Assembly Immune Response-activating Cell Surface Receptor Signaling Pathway Phosphoserine Residue Binding Positive Regulation Of Cell-cell Adhesion SH2 Domain Binding Positive Regulation Of T Cell Activation Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Immune System Process Positive Regulation Of Leukocyte Cell-cell Adhesion Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Leukocyte Cell-cell Adhesion Insulin Receptor Binding Regulation Of T Cell Activation Negative Regulation Of Immune Response Regulation Of Cell-substrate Adhesion
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?