ERCC3 and MAGED1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ERCC3	MAGED1
Description		ERCC excision repair 3, TFIIH core complex helicase subunit	MAGE family member D1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleotide-excision Repair Factor 3 Complex Transcription Factor TFIIH Core Complex Nucleus Nucleoplasm Transcription Factor TFIID Complex Transcription Factor TFIIH Holo Complex Transcription Preinitiation Complex	Chromatin Nucleus Cytoplasm Cytosol Plasma Membrane Membrane Protein-containing Complex
	Molecular Function	Nucleotide Binding DNA Binding DNA Helicase Activity Damaged DNA Binding Helicase Activity Protein Binding ATP Binding Hydrolase Activity Isomerase Activity ATP Hydrolysis Activity 3'-5' DNA Helicase Activity Promoter-specific Chromatin Binding	Transcription Coactivator Activity Protein Binding Identical Protein Binding
	Biological Process	DNA Topological Change DNA Repair Transcription-coupled Nucleotide-excision Repair Nucleotide-excision Repair Transcription By RNA Polymerase II Transcription Initiation At RNA Polymerase II Promoter Transcription Elongation By RNA Polymerase II Apoptotic Process DNA Damage Response Response To Oxidative Stress Intracellular Protein Localization Response To UV UV Protection Hair Cell Differentiation Positive Regulation Of Apoptotic Process Embryonic Organ Development Regulation Of Mitotic Cell Cycle Phase Transition	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Circadian Regulation Of Gene Expression Protein Localization To Nucleus Regulation Of Circadian Rhythm Regulation Of Apoptotic Process Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Rhythmic Process Negative Regulation Of Epithelial Cell Proliferation Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Negative Regulation Of Protein Localization To Nucleus Positive Regulation Of Apoptotic Signaling Pathway
Pathways		Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex RNA Pol II CTD phosphorylation and interaction with CE during HIV infection HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome Formation of HIV-1 elongation complex containing HIV-1 Tat Tat-mediated elongation of the HIV-1 transcript NoRC negatively regulates rRNA expression Formation of Incision Complex in GG-NER Dual Incision in GG-NER RNA Polymerase II Pre-transcription Events Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER TP53 Regulates Transcription of DNA Repair Genes mRNA Capping RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase I Transcription Termination RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Elongation RNA Polymerase II Transcription Initiation And Promoter Clearance RNA Pol II CTD phosphorylation and interaction with CE	NRAGE signals death through JNK Caspase activation via Dependence Receptors in the absence of ligand
Drugs
Diseases		Disorders of nucleotide excision repair, including: Xeroderma pigmentosum (XP); Cockayne syndrome (CS); UV-sensitive syndrome (UVS); Trichothiodystrophy (TTD); Cerebro-oculo-facio-skeletal syndrome (COFS); XFE progeroid syndrome
GWAS			Bell's palsy ( 33602968)
Interacting Genes		38 interacting genes: ADAMTSL4 AR BCR BLZF1 CCNC CCNH CDC42 CDK7 CDK8 CEP70 CEP76 E2F1 ERCC2 GOLGA2 GTF2E1 GTF2E2 GTF2H1 GTF2H2 GTF2H3 GTF2H4 GTF2H5 KPNA3 MAGED1 MCF2 MNAT1 MSANTD2 PSMC5 RAD52 ROPN1 SNW1 SRPK2 TP53 TRIM14 TRIM27 TUBG1 XIAP XPC ZSCAN1	128 interacting genes: AGRN AKAP9 ARHGEF16 ARID5A ARNT2 BAG3 BAG4 BARD1 BHLHE40 BIRC8 BRCA2 C1orf94 CA8 CAPN7 CCDC120 CCDC33 CDC23 CERCAM CFAP206 CHERP DAB1 DAZAP2 DDX6 DLX4 DLX5 DMRT2 EIF3J EIF4E2 EP300 ERCC3 FAM83A FOXD2 FOXH1 FOXI1 FXR1 FXR2 GATA5 GLRA1 GLYCTK GPANK1 GPR135 GRAP2 HEMK1 HGS HIVEP1 HNRNPH1 HNRNPLL HOXC9 HSF2BP HUNK KPNA2 KPNA6 KRTAP19-5 KRTAP6-1 KRTAP6-3 LARP4B LENG8 LONRF1 MAPK1IP1L MAPK3 MDFI MEOX2 MGAT5B MKRN3 MPC1 MSX2 NAF1 NGFR NOTCH1 NOTO NPAS4 NUMBL PHF1 PITX1 PJA1 PJA2 PLK1 PNMA5 POM121 PRKAB2 PROP1 PRR20A PRR20B PRR20C PRR20D PRR20E PRR35 PSMF1 RAMAC RBFOX1 RBFOX2 RBM23 RBPMS RBPMS2 RFX1 RHOXF2 RNF6 RNF8 ROR2 RUSC1 RXFP4 SIM2 SIRT7 SMAP2 SMN1 SMN2 SNRPC SOX10 SOX5 TBX6 TFG TIAL1 TLX3 TRAF4 TRIM28 TSGA10IP TTC23 TTC32 TUBA4A UNC5A VASP VENTX XIAP YTHDF1 ZFYVE26 ZIC1 ZNF488 ZNF688
Entrez ID		2071	9500
HPRD ID		00593	02202
Ensembl ID		ENSG00000163161	ENSG00000179222
Uniprot IDs		B3KRG2 B3KTH1 P19447	Q9Y5V3
PDB IDs		4ERN 5IVW 5IY6 5IY7 5IY8 5IY9 5OF4 6NMI 6O9L 6O9M 6RO4 7AD8 7EGB 7EGC 7ENA 7ENC 7LBM 7NVR 7NVV 7NVW 7NVX 7NVY 7NVZ 7NW0 8BVW 8BYQ 8EBS 8EBT 8EBU 8EBV 8EBW 8EBX 8EBY 8GXQ 8GXS 8WAK 8WAL 8WAN 8WAO 8WAP 8WAQ 8WAR 8WAS
Enriched GO Terms of Interacting Partners?		Transcription Factor TFIIH Core Complex Transcription Factor TFIIH Holo Complex Transcription Initiation At RNA Polymerase II Promoter Nucleotide-excision Repair DNA-templated Transcription Initiation Transcription Factor TFIID Complex DNA-templated Transcription CAK-ERCC2 Complex RNA Polymerase II General Transcription Initiation Factor Activity DNA Damage Response Transcription By RNA Polymerase II Nucleobase-containing Compound Biosynthetic Process Transcription Factor TFIIK Complex DNA Repair Core TFIIH Complex Portion Of Holo TFIIH Complex RNA Metabolic Process Nucleoplasm Cyclin-dependent Protein Kinase Holoenzyme Complex Nucleic Acid Metabolic Process Nucleus Regulation Of Cell Cycle DNA Metabolic Process Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Cellular Response To Stress Transcription Factor TFIIE Complex Regulation Of Nucleobase-containing Compound Metabolic Process Macromolecule Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Process Regulation Of G1/S Transition Of Mitotic Cell Cycle Protein-containing Complex Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Primary Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process CKM Complex Regulation Of Cell Cycle Phase Transition Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of Nucleobase-containing Compound Metabolic Process Signal Transduction By P53 Class Mediator Positive Regulation Of Biosynthetic Process Positive Regulation Of RNA Metabolic Process Transcription Elongation By RNA Polymerase I Regulation Of Macromolecule Biosynthetic Process	Regulation Of RNA Metabolic Process Cytoplasmic Stress Granule Sequence-specific Double-stranded DNA Binding Chromatin Regulation Of Nucleobase-containing Compound Metabolic Process Protein Binding Regulation Of Primary Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Gene Expression DNA Binding Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process System Development Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Nucleus Positive Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Factor Activity RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of Macromolecule Metabolic Process Nucleic Acid Binding Nervous System Development Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Biosynthetic Process Regulation Of MRNA Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Pattern Specification Process Embryonic Morphogenesis MRNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Identical Protein Binding Negative Regulation Of RNA Metabolic Process Cytoplasmic Ribonucleoprotein Granule Nuclear Androgen Receptor Binding RNA Binding Entry Of Viral Genome Into Host Nucleus Through Nuclear Pore Complex Via Importin Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Positive Regulation Of Protein Import Into Nucleus Regulation Of Nucleocytoplasmic Transport Viral Penetration Into Host Nucleus Regulation Of RNA Splicing Transcription Regulator Complex
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