ERCC3 and GTF2H4

Number of citations of the paper that reports this interaction (PMID 9118947)
12

Data Source:
HPRD (in vitro, in vivo)

		ERCC3	GTF2H4
Gene Name		excision repair cross-complementation group 3	general transcription factor IIH, polypeptide 4, 52kDa
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Core TFIIH Complex Nucleus Nucleoplasm Holo TFIIH Complex	Core TFIIH Complex Nucleoplasm Holo TFIIH Complex
	Molecular Function	DNA Binding Damaged DNA Binding ATP-dependent DNA Helicase Activity Protein Kinase Activity Protein Binding ATP Binding GTP Binding Protein C-terminus Binding DNA-dependent ATPase Activity Transcription Factor Binding RNA Polymerase II Carboxy-terminal Domain Kinase Activity ATPase Activity DATP Binding Peptide Binding 3'-5' DNA Helicase Activity Protein N-terminus Binding	Sequence-specific DNA Binding Transcription Factor Activity ATP-dependent DNA Helicase Activity Protein Kinase Activity Protein Binding DNA-dependent ATPase Activity RNA Polymerase II Carboxy-terminal Domain Kinase Activity
	Biological Process	Nucleotide-excision Repair, DNA Duplex Unwinding Nucleotide-excision Repair, DNA Damage Removal Response To Hypoxia DNA Topological Change DNA Repair Transcription-coupled Nucleotide-excision Repair Nucleotide-excision Repair Transcription From RNA Polymerase I Promoter Transcription Initiation From RNA Polymerase I Promoter Transcription Elongation From RNA Polymerase I Promoter Termination Of RNA Polymerase I Transcription Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter 7-methylguanosine MRNA Capping Protein Phosphorylation Apoptotic Process Response To Oxidative Stress Protein Localization Response To UV UV Protection Gene Expression Viral Process Nucleotide-excision Repair, DNA Incision Hair Cell Differentiation Regulation Of Gene Expression, Epigenetic Positive Regulation Of Apoptotic Process Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Viral Transcription Regulation Of Mitotic Cell Cycle Phase Transition	Nucleotide-excision Repair, DNA Damage Removal DNA Repair Transcription-coupled Nucleotide-excision Repair Nucleotide-excision Repair Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase I Promoter Transcription Initiation From RNA Polymerase I Promoter Transcription Elongation From RNA Polymerase I Promoter Termination Of RNA Polymerase I Transcription Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter 7-methylguanosine MRNA Capping Protein Phosphorylation Gene Expression Viral Process DNA Duplex Unwinding Regulation Of Gene Expression, Epigenetic Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of Viral Transcription
Pathways		RNA Polymerase II Promoter Escape Formation of HIV-1 elongation complex containing HIV-1 Tat Nucleotide Excision Repair RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase I Chain Elongation RNA Polymerase II Transcription RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Clearance HIV Infection Formation of the Early Elongation Complex Tat-mediated elongation of the HIV-1 transcript Formation of transcription-coupled NER (TC-NER) repair complex RNA Pol II CTD phosphorylation and interaction with CE RNA Polymerase II Pre-transcription Events Dual incision reaction in TC-NER NoRC negatively regulates rRNA expression HIV Transcription Initiation HIV Life Cycle RNA Pol II CTD phosphorylation and interaction with CE RNA Polymerase II HIV Promoter Escape HIV Transcription Elongation Dual incision reaction in GG-NER mRNA Capping RNA Polymerase I Transcription RNA Polymerase I Promoter Escape RNA Polymerase I Transcription Termination Epigenetic regulation of gene expression Negative epigenetic regulation of rRNA expression Late Phase of HIV Life Cycle Formation of RNA Pol II elongation complex Global Genomic NER (GG-NER) RNA Polymerase II Transcription Initiation And Promoter Clearance Transcription-coupled NER (TC-NER) Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex Formation of incision complex in GG-NER RNA Polymerase II Transcription Initiation Transcription of the HIV genome RNA Polymerase II Transcription Elongation	RNA Polymerase II Promoter Escape Formation of HIV-1 elongation complex containing HIV-1 Tat Nucleotide Excision Repair RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase I Chain Elongation RNA Polymerase II Transcription RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Clearance HIV Infection Formation of the Early Elongation Complex Tat-mediated elongation of the HIV-1 transcript Formation of transcription-coupled NER (TC-NER) repair complex RNA Pol II CTD phosphorylation and interaction with CE RNA Polymerase II Pre-transcription Events Dual incision reaction in TC-NER NoRC negatively regulates rRNA expression HIV Transcription Initiation HIV Life Cycle RNA Pol II CTD phosphorylation and interaction with CE RNA Polymerase II HIV Promoter Escape HIV Transcription Elongation Dual incision reaction in GG-NER mRNA Capping RNA Polymerase I Transcription RNA Polymerase I Promoter Escape RNA Polymerase I Transcription Termination Epigenetic regulation of gene expression Negative epigenetic regulation of rRNA expression Late Phase of HIV Life Cycle Formation of RNA Pol II elongation complex Global Genomic NER (GG-NER) RNA Polymerase II Transcription Initiation And Promoter Clearance Transcription-coupled NER (TC-NER) Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex Formation of incision complex in GG-NER RNA Polymerase II Transcription Initiation Transcription of the HIV genome RNA Polymerase II Transcription Elongation
Drugs
Diseases
GWAS			Ulcerative colitis ( 20848476)
Protein-Protein Interactions		26 interactors: AR BCR CCNC CCNH CDK7 CDK8 CEP70 E2F1 ERCC2 GTF2E1 GTF2E2 GTF2H1 GTF2H2 GTF2H3 GTF2H4 GTF2H5 KPNA3 MNAT1 MSANTD2 PSMC5 RAD52 SRPK2 TP53 XIAP XPC ZSCAN1	10 interactors: ERCC3 ERCC5 GTF2B GTF2E1 GTF2F1 GTF2H3 POLR2A TBP TP53 XBP1P1
Entrez ID		2071	2968
HPRD ID		00593	03456
Ensembl ID		ENSG00000163161	ENSG00000213780
Uniprot IDs		G3V1S1 P19447	Q92759
PDB IDs		4ERN
Enriched GO Terms of Interacting Partners?		Nucleotide-excision Repair, DNA Damage Removal Transcription Initiation From RNA Polymerase II Promoter Nucleotide-excision Repair Transcription Elongation From RNA Polymerase I Promoter DNA-templated Transcription, Elongation Transcription From RNA Polymerase I Promoter DNA-templated Transcription, Initiation Transcription Elongation From RNA Polymerase II Promoter Termination Of RNA Polymerase I Transcription Transcription Initiation From RNA Polymerase I Promoter 7-methylguanosine MRNA Capping 7-methylguanosine RNA Capping Transcription From RNA Polymerase II Promoter Positive Regulation Of Viral Process Transcription-coupled Nucleotide-excision Repair Positive Regulation Of Viral Transcription Cellular Response To DNA Damage Stimulus Viral Process Regulation Of Viral Transcription DNA-templated Transcription, Termination Negative Regulation Of Gene Expression, Epigenetic DNA Catabolic Process Regulation Of Viral Process Transcription, DNA-templated DNA Repair RNA Biosynthetic Process Regulation Of Cell Cycle Cellular Response To Stress RNA Metabolic Process Positive Regulation Of Gene Expression Nucleobase-containing Compound Metabolic Process Gene Expression Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Gene Expression, Epigenetic Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process DNA Metabolic Process Nitrogen Compound Metabolic Process MRNA Processing Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Aromatic Compound Catabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process MRNA Metabolic Process Positive Regulation Of Cellular Metabolic Process RNA Processing Regulation Of Gene Expression	Transcription Elongation From RNA Polymerase II Promoter DNA-templated Transcription, Elongation Transcription Initiation From RNA Polymerase II Promoter DNA-templated Transcription, Initiation Viral Process Transcription From RNA Polymerase II Promoter Nucleotide-excision Repair 7-methylguanosine MRNA Capping 7-methylguanosine RNA Capping Transcription-coupled Nucleotide-excision Repair Positive Regulation Of Viral Transcription Regulation Of Viral Transcription Positive Regulation Of Viral Process Nucleotide-excision Repair, DNA Damage Removal Transcription, DNA-templated RNA Biosynthetic Process Termination Of RNA Polymerase I Transcription Transcription Elongation From RNA Polymerase I Promoter Transcription Initiation From RNA Polymerase I Promoter Transcription From RNA Polymerase I Promoter Regulation Of Viral Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process RNA Metabolic Process DNA Repair Gene Expression Nitrogen Compound Metabolic Process Nucleotide-excision Repair, DNA Incision Cellular Macromolecule Biosynthetic Process DNA-templated Transcription, Termination Negative Regulation Of Gene Expression, Epigenetic Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Cellular Response To DNA Damage Stimulus Positive Regulation Of Cellular Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process MRNA Processing UV Protection Response To UV DNA Catabolic Process DNA Metabolic Process Biosynthetic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process
Tagcloud ?		3b aa8 adp antiapoptotic became carrying cho concordance confer delay determinant ercc1 erk2 excision g5 hamster mtt ner ovary pair parental phosphatidylinositol pi player repair ribose uv24 withdrawal xpb
Tagcloud (Difference) ?		3b aa8 adp antiapoptotic became carrying cho concordance confer delay determinant ercc1 erk2 excision g5 hamster mtt ner ovary pair parental phosphatidylinositol pi player repair ribose uv24 withdrawal xpb
Tagcloud (Intersection) ?