GTF2F2 and TSC22D1

		GTF2F2	TSC22D1
Description		general transcription factor IIF subunit 2	TSC22 domain family member 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Factor TFIIF Complex Microtubule Cytoskeleton RNA Polymerase II, Holoenzyme RNA Polymerase II Transcription Regulator Complex	Nucleus Cytoplasm Mitochondrion Cytosol Plasma Membrane Membrane
	Molecular Function	DNA Binding Protein Binding RNA Polymerase II General Transcription Initiation Factor Activity	Transcription Coactivator Activity Protein Binding Identical Protein Binding
	Biological Process	Transcription By RNA Polymerase II Transcription Initiation At RNA Polymerase II Promoter Transcription Elongation By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II	Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Positive Regulation Of Cell Population Proliferation Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Negative Regulation Of Programmed Cell Death Positive Regulation Of DNA-templated Transcription Negative Regulation Of Hematopoietic Stem Cell Proliferation
Pathways		Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex RNA Pol II CTD phosphorylation and interaction with CE during HIV infection HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome Formation of HIV-1 elongation complex containing HIV-1 Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Abortive elongation of HIV-1 transcript in the absence of Tat Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation Viral Messenger RNA Synthesis RNA Polymerase II Pre-transcription Events TP53 Regulates Transcription of DNA Repair Genes FGFR2 alternative splicing RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes mRNA Capping mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Elongation RNA Polymerase II Transcription Initiation And Promoter Clearance RNA Pol II CTD phosphorylation and interaction with CE Signaling by FGFR2 IIIa TM Estrogen-dependent gene expression
Drugs
Diseases
GWAS		Normal facial asymmetry (angle of surface orientation score) ( 30631343) Type 2 diabetes ( 25760438)	Antineutrophil cytoplasmic antibody-associated vasculitis ( 22808956) Body mass index ( 25760438) Refractive error ( 32231278) Rosacea symptom severity ( 29771307)
Interacting Genes		30 interacting genes: AHR AR ARNT ATF2 ATF4 CEBPA CEBPG CREB1 DYNLT2B FHL2 FOS GTF2B GTF2E1 GTF2E2 GTF2F1 HMGA1 HTATSF1 JUN KLF5 MAPRE3 MSX2 POLR2E RPL27A TAF5 TBP TCEA1 TRAM2 URI1 YEATS4 ZMYND19	51 interacting genes: A2M APLP1 ASAH1 CACNA1A CARHSP1 CCDC90B CFTR CHD3 CORO2B CRMP1 DDAH2 DNMT3B EED ERG28 FAF1 FAM20C FBN3 GNB2 GNB5 GORASP2 HMGXB4 KMT2B KMT2C LRIF1 MAP3K12 MCM3AP NCOA5 NTAQ1 OTUB1 PDHB PRKCI PTN QARS1 RGS1 RPL5 SETDB1 SP110 SPACA9 SPRED1 TAF5L TGFBR1 TLE1 TP53 TSC22D4 UBE2D1 UNC119 VIM WDR73 WIZ WNK1 ZC3HC1
Entrez ID		2963	8848
HPRD ID		01804	07414
Ensembl ID		ENSG00000188342	ENSG00000102804
Uniprot IDs		P13984	A8K3Y6 Q15714
PDB IDs		1BBY 1F3U 2BBY 5IY6 5IY7 5IY8 5IY9 5IYA 5IYB 5IYC 5IYD 6O9L 7EDX 7EG7 7EG8 7EG9 7EGA 7EGB 7EGC 7ENA 7ENC 7LBM 7NVR 7NVS 7NVT 7NVU 7NVY 7NVZ 7NW0 7ZWD 7ZX7 7ZX8 8BVW 8BYQ 8BZ1 8GXQ 8GXS 8S51 8S52 8S54 8S55 8S5N 8WAK 8WAL 8WAN 8WAO 8WAP 8WAQ 8WAR 8WAS 8WAT 8WAU 8WAV 8WAW 8WAX 8WAY 8WAZ 8WB0
Enriched GO Terms of Interacting Partners?		DNA-templated Transcription Transcription By RNA Polymerase II RNA Polymerase II Transcription Regulator Complex Nucleobase-containing Compound Biosynthetic Process Transcription Factor TFIID Complex Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription RNA Polymerase II-specific DNA-binding Transcription Factor Binding Nucleoplasm Positive Regulation Of RNA Metabolic Process RNA Metabolic Process Transcription Regulator Complex Macromolecule Biosynthetic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process DNA Binding RNA Polymerase II General Transcription Initiation Factor Activity Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II MRNA Transcription By RNA Polymerase II Transcription Initiation At RNA Polymerase II Promoter Chromatin Positive Regulation Of Macromolecule Biosynthetic Process Nucleic Acid Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Cis-regulatory Region Binding MRNA Transcription Promoter-specific Chromatin Binding DNA-templated Transcription Initiation Sequence-specific Double-stranded DNA Binding Integrated Stress Response Signaling Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of Macromolecule Metabolic Process Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Factor Activity RNA Polymerase II Core Promoter Sequence-specific DNA Binding Nucleus DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of Metabolic Process Regulation Of Gene Expression RNA Polymerase II General Transcription Initiation Factor Binding Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of DNA-templated Transcription Initiation Regulation Of Primary Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of DNA-templated Transcription Initiation	Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Signal Transduction Regulation Of Primary Metabolic Process Nucleus Nucleoplasm Negative Regulation Of Cell Communication Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Regulation Of Metabolic Process Negative Regulation Of Signaling Histone H3K4 Monomethyltransferase Activity Histone H3K4 Trimethyltransferase Activity
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