GTF2F2 and TRAM2

Number of citations of the paper that reports this interaction (PubMedID 14612417)
41

Data Source:
HPRD (in vivo)

		GTF2F2	TRAM2
Description		general transcription factor IIF subunit 2	translocation associated membrane protein 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Factor TFIIF Complex Microtubule Cytoskeleton RNA Polymerase II, Holoenzyme RNA Polymerase II Transcription Regulator Complex	Endoplasmic Reticulum Membrane Membrane
	Molecular Function	DNA Binding Protein Binding RNA Polymerase II General Transcription Initiation Factor Activity	Protein Binding
	Biological Process	Transcription By RNA Polymerase II Transcription Initiation At RNA Polymerase II Promoter Transcription Elongation By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II	SRP-dependent Cotranslational Protein Targeting To Membrane, Translocation Protein Transport Collagen Biosynthetic Process Protein Insertion Into ER Membrane
Pathways		Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex RNA Pol II CTD phosphorylation and interaction with CE during HIV infection HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome Formation of HIV-1 elongation complex containing HIV-1 Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Abortive elongation of HIV-1 transcript in the absence of Tat Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation Viral Messenger RNA Synthesis RNA Polymerase II Pre-transcription Events TP53 Regulates Transcription of DNA Repair Genes FGFR2 alternative splicing RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes mRNA Capping mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Elongation RNA Polymerase II Transcription Initiation And Promoter Clearance RNA Pol II CTD phosphorylation and interaction with CE Signaling by FGFR2 IIIa TM Estrogen-dependent gene expression
Drugs
Diseases
GWAS		Normal facial asymmetry (angle of surface orientation score) ( 30631343) Type 2 diabetes ( 25760438)	Apolipoprotein B levels ( 32203549) Appendicular lean mass ( 33097823) Atopic march ( 26542096) Intraocular pressure ( 29617998) LDL cholesterol levels ( 28334899) Lipid traits (pleiotropy) (HIPO component 2) ( 30289880) Low density lipoprotein cholesterol levels ( 29083408) Total cholesterol levels ( 28334899)
Interacting Genes		30 interacting genes: AHR AR ARNT ATF2 ATF4 CEBPA CEBPG CREB1 DYNLT2B FHL2 FOS GTF2B GTF2E1 GTF2E2 GTF2F1 HMGA1 HTATSF1 JUN KLF5 MAPRE3 MSX2 POLR2E RPL27A TAF5 TBP TCEA1 TRAM2 URI1 YEATS4 ZMYND19	4 interacting genes: GTF2B GTF2F2 POLR2A TBP
Entrez ID		2963	9697
HPRD ID		01804	16338
Ensembl ID		ENSG00000188342	ENSG00000065308
Uniprot IDs		P13984	A0A024RD84 Q15035
PDB IDs		1BBY 1F3U 2BBY 5IY6 5IY7 5IY8 5IY9 5IYA 5IYB 5IYC 5IYD 6O9L 7EDX 7EG7 7EG8 7EG9 7EGA 7EGB 7EGC 7ENA 7ENC 7LBM 7NVR 7NVS 7NVT 7NVU 7NVY 7NVZ 7NW0 7ZWD 7ZX7 7ZX8 8BVW 8BYQ 8BZ1 8GXQ 8GXS 8S51 8S52 8S54 8S55 8S5N 8WAK 8WAL 8WAN 8WAO 8WAP 8WAQ 8WAR 8WAS 8WAT 8WAU 8WAV 8WAW 8WAX 8WAY 8WAZ 8WB0
Enriched GO Terms of Interacting Partners?		DNA-templated Transcription Transcription By RNA Polymerase II RNA Polymerase II Transcription Regulator Complex Nucleobase-containing Compound Biosynthetic Process Transcription Factor TFIID Complex Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription RNA Polymerase II-specific DNA-binding Transcription Factor Binding Nucleoplasm Positive Regulation Of RNA Metabolic Process RNA Metabolic Process Transcription Regulator Complex Macromolecule Biosynthetic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process DNA Binding RNA Polymerase II General Transcription Initiation Factor Activity Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II MRNA Transcription By RNA Polymerase II Transcription Initiation At RNA Polymerase II Promoter Chromatin Positive Regulation Of Macromolecule Biosynthetic Process Nucleic Acid Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Cis-regulatory Region Binding MRNA Transcription Promoter-specific Chromatin Binding DNA-templated Transcription Initiation Sequence-specific Double-stranded DNA Binding Integrated Stress Response Signaling Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of Macromolecule Metabolic Process Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Factor Activity RNA Polymerase II Core Promoter Sequence-specific DNA Binding Nucleus DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of Metabolic Process Regulation Of Gene Expression RNA Polymerase II General Transcription Initiation Factor Binding Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of DNA-templated Transcription Initiation Regulation Of Primary Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of DNA-templated Transcription Initiation	RNA Polymerase II General Transcription Initiation Factor Activity Transcription Initiation At RNA Polymerase II Promoter Transcription By RNA Polymerase II DNA-templated Transcription Initiation DNA-templated Transcription RNA Polymerase II Core Promoter Sequence-specific DNA Binding Transcription Factor TFIID Complex Nucleobase-containing Compound Biosynthetic Process Transcription Elongation By RNA Polymerase II MRNA Transcription By RNA Polymerase II RNA Polymerase II Preinitiation Complex Assembly DNA-templated Transcription Elongation MRNA Transcription Transcription Preinitiation Complex Assembly Promoter-specific Chromatin Binding RNA Metabolic Process Macromolecule Biosynthetic Process Transcriptional Start Site Selection At RNA Polymerase II Promoter RNA Polymerase II, Holoenzyme RNA Polymerase II Core Complex Assembly RNA Polymerase II Transcription Regulator Complex Transcription Factor TFIIF Complex Positive Regulation Of Core Promoter Binding Nucleic Acid Metabolic Process RNA-directed RNA Polymerase Activity RNA-templated Transcription DNA Binding DNA-binding Transcription Factor Binding Germinal Vesicle Protein-DNA Complex Assembly TFIIB-class Transcription Factor Binding Microfibril Binding RNA Polymerase Transcription Factor SL1 Complex Transcription Factor TFIIA Complex Viral Transcription 5'-3' RNA Polymerase Activity RNA Polymerase II General Transcription Initiation Factor Binding Pronucleus Nucleobase-containing Compound Metabolic Process Male Pronucleus Aryl Hydrocarbon Receptor Binding Lung-associated Mesenchyme Development RNA Polymerase I Core Promoter Sequence-specific DNA Binding RNA Polymerase I Preinitiation Complex Assembly Female Pronucleus Meiotic Sister Chromatid Cohesion Positive Regulation Of Transcription Regulatory Region DNA Binding Axon Guidance Receptor Activity RNA Polymerase III General Transcription Initiation Factor Activity Transcription Preinitiation Complex
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