GTF2F2 and HTATSF1

Number of citations of the paper that reports this interaction (PubMedID 10454543)
45

Data Source:
HPRD (in vitro, in vivo)

		GTF2F2	HTATSF1
Description		general transcription factor IIF subunit 2	HIV-1 Tat specific factor 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Factor TFIIF Complex Microtubule Cytoskeleton RNA Polymerase II, Holoenzyme RNA Polymerase II Transcription Regulator Complex	Nucleus Nucleoplasm Spliceosomal Complex U2-type Spliceosomal Complex U2 SnRNP Chromosome Site Of Double-strand Break
	Molecular Function	DNA Binding Protein Binding RNA Polymerase II General Transcription Initiation Factor Activity	Nucleic Acid Binding RNA Binding Protein Binding Chromatin-protein Adaptor Activity Poly-ADP-D-ribose Modification-dependent Protein Binding
	Biological Process	Transcription By RNA Polymerase II Transcription Initiation At RNA Polymerase II Promoter Transcription Elongation By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II	MRNA Splicing, Via Spliceosome Double-strand Break Repair Via Homologous Recombination DNA Repair Chromatin Organization MRNA Processing DNA Damage Response RNA Splicing U2-type Prespliceosome Assembly Protein Localization To Site Of Double-strand Break
Pathways		Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex RNA Pol II CTD phosphorylation and interaction with CE during HIV infection HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome Formation of HIV-1 elongation complex containing HIV-1 Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Abortive elongation of HIV-1 transcript in the absence of Tat Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation Viral Messenger RNA Synthesis RNA Polymerase II Pre-transcription Events TP53 Regulates Transcription of DNA Repair Genes FGFR2 alternative splicing RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes mRNA Capping mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Elongation RNA Polymerase II Transcription Initiation And Promoter Clearance RNA Pol II CTD phosphorylation and interaction with CE Signaling by FGFR2 IIIa TM Estrogen-dependent gene expression	mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		Normal facial asymmetry (angle of surface orientation score) ( 30631343) Type 2 diabetes ( 25760438)
Interacting Genes		30 interacting genes: AHR AR ARNT ATF2 ATF4 CEBPA CEBPG CREB1 DYNLT2B FHL2 FOS GTF2B GTF2E1 GTF2E2 GTF2F1 HMGA1 HTATSF1 JUN KLF5 MAPRE3 MSX2 POLR2E RPL27A TAF5 TBP TCEA1 TRAM2 URI1 YEATS4 ZMYND19	21 interacting genes: APBB1 CCNT1 CDK9 CLK1 CSNK2A1 ERCC6 FEZ1 GTF2F2 HDAC6 MAP1LC3A POLR2A RNF10 SF3A2 SNRNP70 SNRPB2 SRPK2 SRSF4 SUPT4H1 SUPT5H WBP4 ZNF512B
Entrez ID		2963	27336
HPRD ID		01804	02282
Ensembl ID		ENSG00000188342	ENSG00000102241
Uniprot IDs		P13984	O43719
PDB IDs		1BBY 1F3U 2BBY 5IY6 5IY7 5IY8 5IY9 5IYA 5IYB 5IYC 5IYD 6O9L 7EDX 7EG7 7EG8 7EG9 7EGA 7EGB 7EGC 7ENA 7ENC 7LBM 7NVR 7NVS 7NVT 7NVU 7NVY 7NVZ 7NW0 7ZWD 7ZX7 7ZX8 8BVW 8BYQ 8BZ1 8GXQ 8GXS 8S51 8S52 8S54 8S55 8S5N 8WAK 8WAL 8WAN 8WAO 8WAP 8WAQ 8WAR 8WAS 8WAT 8WAU 8WAV 8WAW 8WAX 8WAY 8WAZ 8WB0	2DIT 6N3D 6N3E 6N3F 6NSX 6Y50 6Y53 6Y5Q 7EVO 7Q3L 8HK1
Enriched GO Terms of Interacting Partners?		DNA-templated Transcription Transcription By RNA Polymerase II RNA Polymerase II Transcription Regulator Complex Nucleobase-containing Compound Biosynthetic Process Transcription Factor TFIID Complex Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription RNA Polymerase II-specific DNA-binding Transcription Factor Binding Nucleoplasm Positive Regulation Of RNA Metabolic Process RNA Metabolic Process Transcription Regulator Complex Macromolecule Biosynthetic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process DNA Binding RNA Polymerase II General Transcription Initiation Factor Activity Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II MRNA Transcription By RNA Polymerase II Transcription Initiation At RNA Polymerase II Promoter Chromatin Positive Regulation Of Macromolecule Biosynthetic Process Nucleic Acid Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Cis-regulatory Region Binding MRNA Transcription Promoter-specific Chromatin Binding DNA-templated Transcription Initiation Sequence-specific Double-stranded DNA Binding Integrated Stress Response Signaling Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of Macromolecule Metabolic Process Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Factor Activity RNA Polymerase II Core Promoter Sequence-specific DNA Binding Nucleus DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of Metabolic Process Regulation Of Gene Expression RNA Polymerase II General Transcription Initiation Factor Binding Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of DNA-templated Transcription Initiation Regulation Of Primary Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of DNA-templated Transcription Initiation	RNA Metabolic Process DNA-templated Transcription Elongation Nucleic Acid Metabolic Process Transcription Elongation By RNA Polymerase II Nucleoplasm Positive Regulation Of DNA-templated Transcription, Elongation Nucleobase-containing Compound Metabolic Process Regulation Of Transcription Elongation By RNA Polymerase II Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Elongation Nucleus Regulation Of Nucleobase-containing Compound Metabolic Process MRNA Metabolic Process Nuclear Speck Regulation Of Gene Expression P-TEFb Complex DSIF Complex Regulation Of Macromolecule Biosynthetic Process Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Regulation Of RNA Splicing Negative Regulation Of DNA-templated Transcription, Elongation RNA Splicing RNA Splicing, Via Transesterification Reactions Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nucleobase-containing Compound Biosynthetic Process Regulation Of Metabolic Process DNA-templated Transcription MRNA Processing Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of MRNA Processing Transcription By RNA Polymerase II Spliceosomal Complex Assembly Transcription Elongation-coupled Chromatin Remodeling U2-type Precatalytic Spliceosome Negative Regulation Of Metabolic Process Cyclin/CDK Positive Transcription Elongation Factor Complex U1 SnRNA Binding Positive Regulation Of Transcription Elongation By RNA Polymerase II 7SK SnRNA Binding Nucleic Acid Binding Positive Regulation Of Metabolic Process Spliceosomal Complex Regulation Of Transcription By RNA Polymerase II Double-strand Break Repair Via Classical Nonhomologous End Joining Regulation Of Autophagy Positive Regulation Of Transcription By RNA Polymerase II SnRNA Binding
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