SGK3 and GSK3A

Number of citations of the paper that reports this interaction (PMID 11035810)
124

Data Source:
HPRD (in vivo, in vitro)

		SGK3	GSK3A
Gene Name		serum/glucocorticoid regulated kinase family, member 3	glycogen synthase kinase 3 alpha
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Early Endosome Cytosol Cytoplasmic Membrane-bounded Vesicle Recycling Endosome	Cytosol Beta-catenin Destruction Complex
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Calcium Channel Regulator Activity Protein Binding ATP Binding Potassium Channel Regulator Activity Sodium Channel Regulator Activity Chloride Channel Regulator Activity Phosphatidylinositol Binding	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Kinase A Catalytic Subunit Binding Tau-protein Kinase Activity
	Biological Process	Regulation Of Cell Growth Protein Phosphorylation Response To Stress Regulation Of Cell Migration Ion Transmembrane Transport Regulation Of Cell Proliferation Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Transmembrane Transport	Regulation Of Systemic Arterial Blood Pressure Cardiac Left Ventricle Morphogenesis Glycogen Metabolic Process Regulation Of Gene Expression By Genetic Imprinting Protein Phosphorylation Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Epidermal Growth Factor Receptor Signaling Pathway Nervous System Development Insulin Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Peptidyl-threonine Phosphorylation Negative Regulation Of UDP-glucose Catabolic Process Wnt Signaling Pathway Cell Migration Positive Regulation Of CAMP Biosynthetic Process Endoplasmic Reticulum Unfolded Protein Response Negative Regulation Of TOR Signaling Cellular Response To Insulin Stimulus Positive Regulation Of Peptidyl-serine Phosphorylation Cellular Response To Interleukin-3 Fc-epsilon Receptor Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Hypermethylation Of CpG Island Cellular Protein Metabolic Process Innate Immune Response Negative Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Protein Catabolic Process Positive Regulation Of Heart Contraction Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Glucose Import Negative Regulation Of Insulin Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Negative Regulation Of Transferase Activity Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Cellular Response To Lithium Ion Cellular Response To Organic Cyclic Compound Positive Regulation Of Adrenergic Receptor Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Negative Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Glycogen (starch) Synthase Activity Positive Regulation Of Glycogen (starch) Synthase Activity
Pathways		Ion channel transport Stimuli-sensing channels	Signaling by the B Cell Receptor (BCR) Signaling by FGFR in disease PIP3 activates AKT signaling AKT phosphorylates targets in the cytosol Signaling by EGFRvIII in Cancer XBP1(S) activates chaperone genes Signaling by SCF-KIT DAP12 signaling Downstream signaling events of B Cell Receptor (BCR) IRE1alpha activates chaperones PI3K/AKT activation PI-3K cascade PI3K events in ERBB2 signaling Downstream signaling of activated FGFR Unfolded Protein Response (UPR) Innate Immune System Signaling by PDGF DAP12 interactions Signalling by NGF GAB1 signalosome Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by ERBB4 Constitutive PI3K/AKT Signaling in Cancer Role of LAT2/NTAL/LAB on calcium mobilization PI3K events in ERBB4 signaling Signaling by FGFR Signaling by ERBB2 Signaling by EGFR Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		6 interactors: APP GSK3A GSK3B ITCH PDPK1 SLC9A3R2	31 interactors: AKT1 BCL3 BICD1 CREB1 CREM DEAF1 EBNA1BP2 EIF2B5 FAM193B GLI3 GSKIP HSF1 LRSAM1 MAPT MCL1 MYC NBR1 PRKACA PRKCA PRKCB PRKCD PRKCG PRKCH PRKCZ PRKD3 PRKDC PXN SGK1 SGK3 SPG21 YWHAG
Entrez ID		23678	2931
HPRD ID		06349	06002
Ensembl ID		ENSG00000104205	ENSG00000105723
Uniprot IDs		Q53EW6 Q5H9Q5 Q96BR1	P49840
PDB IDs			2DFM
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Type B Pancreatic Cell Development Hypermethylation Of CpG Island Innate Immune Response Cellular Response To Interleukin-3 Apoptotic Process Programmed Cell Death Negative Regulation Of Glycogen (starch) Synthase Activity Cell Death Death Negative Regulation Of Signal Transduction Negative Regulation Of Intracellular Signal Transduction Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Signaling Immune Response-regulating Signaling Pathway Positive Regulation Of Protein Metabolic Process Negative Regulation Of Cardiac Muscle Hypertrophy Locomotion Negative Regulation Of Glycogen Biosynthetic Process Negative Regulation Of Muscle Hypertrophy Regulation Of Glycogen (starch) Synthase Activity Regulation Of Signal Transduction Immune Response Regulation Of Phosphorylation Defense Response Phosphatidylinositol-mediated Signaling Regulation Of Signaling Regulation Of Type B Pancreatic Cell Development Regulation Of Phosphorus Metabolic Process Positive Regulation Of Peptidyl-threonine Phosphorylation Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Growth Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Regulation Of DNA Methylation Regulation Of Intracellular Signal Transduction Regulation Of Protein Kinase Activity Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Protein Catabolic Process Neurotrophin Signaling Pathway Negative Regulation Of Catalytic Activity Fc-epsilon Receptor Signaling Pathway Regulation Of Kinase Activity Positive Regulation Of Intracellular Transport Regulation Of Gene Expression By Genetic Imprinting Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Cardiac Muscle Hypertrophy Response To Lithium Ion Regulation Of Cellular Protein Metabolic Process	Response To Stress Protein Phosphorylation Regulation Of Phospholipase Activity Apoptotic Process Vascular Endothelial Growth Factor Receptor Signaling Pathway Phosphorylation Programmed Cell Death Intrinsic Apoptotic Signaling Pathway Platelet Activation Cell Death Death Positive Regulation Of Phospholipase Activity Cell Activation Negative Regulation Of Cellular Metabolic Process Regulation Of Apoptotic Process Response To Organic Substance Negative Regulation Of Glial Cell Apoptotic Process Positive Regulation Of Lipase Activity Intracellular Signal Transduction Regulation Of Cell Death Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Negative Regulation Of Insulin Receptor Signaling Pathway Histone H3-T6 Phosphorylation Negative Regulation Of Apoptotic Process Activation Of Phospholipase C Activity Negative Regulation Of Programmed Cell Death Positive Regulation Of Cellular Metabolic Process Apoptotic Signaling Pathway Regulation Of Insulin Receptor Signaling Pathway Positive Regulation Of Phospholipase C Activity Negative Regulation Of Cell Death Cellular Response To Stimulus Response To Stimulus Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Phosphorylation Regulation Of Metabolic Process Cellular Response To Growth Factor Stimulus Regulation Of Body Fluid Levels Response To Organonitrogen Compound Developmental Process Response To Growth Factor Phosphate-containing Compound Metabolic Process Wound Healing Regulation Of Cellular Response To Insulin Stimulus Blood Coagulation Hemostasis Response To Peptide Hormone Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of Protein Metabolic Process
Tagcloud ?		androgen ar confers depletion dht eralpha erbeta functionally functioning g1 glucocorticoid identifies inducible inhibiting isoforms lncap locus p70 p70s6k phosphatidylinositol pi3k promoters promotes prostate responsiveness s6 ser summary thr	2h 4e accelerated bp1 carboxymethoxyphenyl deacetylase dimethylthiazol ezh2 glioma gliomas glycogen incubated mts p70 p70s6k pci phosphatidylinositol promotes razolium s6 simulated sirna sulfophenyl suppresses suppressing tet yl zeste
Tagcloud (Difference) ?		androgen ar confers depletion dht eralpha erbeta functionally functioning g1 glucocorticoid identifies inducible inhibiting isoforms lncap locus pi3k promoters prostate responsiveness ser summary thr	2h 4e accelerated bp1 carboxymethoxyphenyl deacetylase dimethylthiazol ezh2 glioma gliomas glycogen incubated mts pci razolium simulated sirna sulfophenyl suppresses suppressing tet yl zeste
Tagcloud (Intersection) ?		p70 p70s6k phosphatidylinositol promotes s6