TCF21 and GTF3C5

Number of citations of the paper that reports this interaction (PMID 20211142)
148

Data Source:
BioGRID (two hybrid)

		TCF21	GTF3C5
Gene Name		transcription factor 21	general transcription factor IIIC, polypeptide 5, 63kDa
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus	Transcription Factor TFIIIC Complex Nucleoplasm
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription Histone Deacetylase Binding BHLH Transcription Factor Binding Protein Dimerization Activity Androgen Receptor Binding E-box Binding	DNA Binding Protein Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Ureteric Bud Development Branching Involved In Ureteric Bud Morphogenesis Morphogenesis Of A Branching Structure Kidney Development Vasculature Development Transcription, DNA-templated Sex Determination Branchiomeric Skeletal Muscle Development Epithelial Cell Differentiation Glomerulus Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Lung Alveolus Development Spleen Development Embryonic Digestive Tract Morphogenesis Reproductive Structure Development Gland Development Sertoli Cell Differentiation Palate Development Lung Morphogenesis Lung Vasculature Development Bronchiole Development Diaphragm Development Respiratory System Development Negative Regulation Of Androgen Receptor Signaling Pathway Metanephric Mesenchymal Cell Differentiation Metanephric Glomerular Capillary Formation	Transcription, DNA-templated Transcription From RNA Polymerase III Promoter Gene Expression Skeletal Muscle Cell Differentiation 5S Class RRNA Transcription From RNA Polymerase III Type 1 Promoter TRNA Transcription From RNA Polymerase III Promoter
Pathways			RNA Polymerase III Transcription RNA Polymerase III Transcription Initiation RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription RNA Polymerase III Abortive And Retractive Initiation RNA Polymerase III Transcription Initiation From Type 2 Promoter
Drugs
Diseases
GWAS		Coronary heart disease ( 22751097 21378990)
Protein-Protein Interactions		7 interactors: APEX1 APLP1 GTF3C5 HOXB6 KLF15 LMO4 TCF3	12 interactors: BRF1 GTF3C3 GTF3C4 GTF3C6 KRT40 KRTAP10-3 MDFI NOTCH2NL SRA1 TBP TCF21 TCF4
Entrez ID		6943	9328
HPRD ID		04493	16077
Ensembl ID		ENSG00000118526	ENSG00000148308
Uniprot IDs		O43680	H9KV68 Q9Y5Q8
PDB IDs
Enriched GO Terms of Interacting Partners?		RNA Metabolic Process Gene Expression Transcription, DNA-templated RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Organ Development Developmental Process Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process System Development Posttranscriptional Regulation Of Gene Expression Cellular Response To Organonitrogen Compound Multicellular Organismal Development Biosynthetic Process Regulation Of Gene Expression Anatomical Structure Development Regulation Of Nitrogen Compound Metabolic Process Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition Tissue Development Positive Regulation Of Transcription From RNA Polymerase II Promoter During Mitosis Cellular Response To Norepinephrine Stimulus Response To Organonitrogen Compound Transcription From RNA Polymerase II Promoter 5S Class RRNA Transcription From RNA Polymerase III Type 1 Promoter TRNA Transcription From RNA Polymerase III Promoter Axial Mesoderm Morphogenesis Response To Norepinephrine Negative Regulation Of Cellular Metabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Phase Transition Immunoglobulin V(D)J Recombination TRNA Transcription DNA Recombination Central Nervous System Development Anterior/posterior Pattern Specification Nervous System Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Axial Mesoderm Development Cellular Metabolic Process Positive Regulation Of Cell Cycle Regulation Of Transcription, DNA-templated Anatomical Structure Morphogenesis B Cell Lineage Commitment Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process	TRNA Transcription Transcription From RNA Polymerase III Promoter RRNA Transcription 5S Class RRNA Transcription From RNA Polymerase III Type 1 Promoter TRNA Transcription From RNA Polymerase III Promoter Transcription, DNA-templated RNA Biosynthetic Process DNA-templated Transcription, Initiation RNA Metabolic Process Transcription Initiation From RNA Polymerase III Promoter Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Embryonic Organ Development Reproductive Structure Development Reproductive System Development Embryonic Digestive Tract Morphogenesis Nucleobase-containing Compound Metabolic Process Single Organism Reproductive Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Embryonic Morphogenesis Reproductive Process Cellular Nitrogen Compound Metabolic Process Embryonic Digestive Tract Development Developmental Process Involved In Reproduction Nitrogen Compound Metabolic Process Embryonic Organ Morphogenesis Transcription From RNA Polymerase II Promoter Digestive Tract Morphogenesis Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Epithelial To Mesenchymal Transition Catenin Import Into Nucleus Embryo Development Multicellular Organism Growth Embryonic Placenta Development Cell Differentiation Blood Vessel Development Vasculature Development Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process Proepicardium Development Negative Regulation Of Gene Expression Digestive Tract Development Negative Regulation Of Biosynthetic Process Maintenance Of DNA Repeat Elements Bronchiole Development Digestive System Development
Tagcloud ?		biologic clustering commitment derivation deviant dissemination etiologies evasion fallopian fimbrial fn1 hgsc homeostatic incidences metastasize modules niche pax8 peg3 quiescence slug sparc speculated speculation subsistence survive thbs2 theme totally	acetylated allowing architecture became branching chipseq coordinated depolarization depolarizing discovered dramatic factories interplay interspersed mimicked nee rearrangement relies relocated relocation remarkably silencing sines somatosensory synaptic tfiiic tfs timely uncontrolled
Tagcloud (Difference) ?		biologic clustering commitment derivation deviant dissemination etiologies evasion fallopian fimbrial fn1 hgsc homeostatic incidences metastasize modules niche pax8 peg3 quiescence slug sparc speculated speculation subsistence survive thbs2 theme totally	acetylated allowing architecture became branching chipseq coordinated depolarization depolarizing discovered dramatic factories interplay interspersed mimicked nee rearrangement relies relocated relocation remarkably silencing sines somatosensory synaptic tfiiic tfs timely uncontrolled
Tagcloud (Intersection) ?