TCF21 and LMO4

Number of citations of the paper that reports this interaction (PMID 15231748)
65

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		TCF21	LMO4
Gene Name		transcription factor 21	LIM domain only 4
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus	Transcription Factor Complex
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription Histone Deacetylase Binding BHLH Transcription Factor Binding Protein Dimerization Activity Androgen Receptor Binding E-box Binding	Enhancer Sequence-specific DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Factor Binding Zinc Ion Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Ureteric Bud Development Branching Involved In Ureteric Bud Morphogenesis Morphogenesis Of A Branching Structure Kidney Development Vasculature Development Transcription, DNA-templated Sex Determination Branchiomeric Skeletal Muscle Development Epithelial Cell Differentiation Glomerulus Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Lung Alveolus Development Spleen Development Embryonic Digestive Tract Morphogenesis Reproductive Structure Development Gland Development Sertoli Cell Differentiation Palate Development Lung Morphogenesis Lung Vasculature Development Bronchiole Development Diaphragm Development Respiratory System Development Negative Regulation Of Androgen Receptor Signaling Pathway Metanephric Mesenchymal Cell Differentiation Metanephric Glomerular Capillary Formation	Neural Tube Closure Ventricular Septum Development Transcription From RNA Polymerase II Promoter Ventral Spinal Cord Interneuron Differentiation Spinal Cord Motor Neuron Differentiation Spinal Cord Association Neuron Differentiation Negative Regulation Of Protein Complex Assembly Regulation Of Cell Fate Specification Positive Regulation Of Transcription From RNA Polymerase II Promoter Thymus Development Regulation Of Cell Activation
Pathways
Drugs
Diseases
GWAS		Coronary heart disease ( 22751097 21378990)	Response to TNF antagonist treatment ( 18615156) White blood cell types ( 21738478)
Protein-Protein Interactions		7 interactors: APEX1 APLP1 GTF3C5 HOXB6 KLF15 LMO4 TCF3	53 interactors: AES AMOT AMOTL2 BANP BRCA1 CALCOCO2 CCDC102B CEP170P1 CSNK2B DDB1 DEAF1 ERCC6L GABPB1 GADD45A GOLGA2 GRHL2 GSK3B ITSN1 KANK2 KIAA1958 KIF3B KPNA1 KRT15 KRT31 KRT40 LDB1 LDB2 MERTK MTA1 NFYC NHLH1 NONO PDE4DIP PITPNB PLK1 PPARG RBBP8 RBPMS RPS6KA6 SEC24D SMAD4 SMAD9 TCF21 TCF4 TFIP11 TINAGL1 TNFSF11 TP53BP2 TSEN15 VPS52 ZBTB43 ZNF397 ZNF675
Entrez ID		6943	8543
HPRD ID		04493	09122
Ensembl ID		ENSG00000118526	ENSG00000143013
Uniprot IDs		O43680	P61968
PDB IDs			2L4Z
Enriched GO Terms of Interacting Partners?		RNA Metabolic Process Gene Expression Transcription, DNA-templated RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Organ Development Developmental Process Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process System Development Posttranscriptional Regulation Of Gene Expression Cellular Response To Organonitrogen Compound Multicellular Organismal Development Biosynthetic Process Regulation Of Gene Expression Anatomical Structure Development Regulation Of Nitrogen Compound Metabolic Process Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition Tissue Development Positive Regulation Of Transcription From RNA Polymerase II Promoter During Mitosis Cellular Response To Norepinephrine Stimulus Response To Organonitrogen Compound Transcription From RNA Polymerase II Promoter 5S Class RRNA Transcription From RNA Polymerase III Type 1 Promoter TRNA Transcription From RNA Polymerase III Promoter Axial Mesoderm Morphogenesis Response To Norepinephrine Negative Regulation Of Cellular Metabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Phase Transition Immunoglobulin V(D)J Recombination TRNA Transcription DNA Recombination Central Nervous System Development Anterior/posterior Pattern Specification Nervous System Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Axial Mesoderm Development Cellular Metabolic Process Positive Regulation Of Cell Cycle Regulation Of Transcription, DNA-templated Anatomical Structure Morphogenesis B Cell Lineage Commitment Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process	Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Regulation Of RNA Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process RNA Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Tissue Development Negative Regulation Of Nucleic Acid-templated Transcription Cellular Nitrogen Compound Metabolic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Multicellular Organismal Development Developmental Process Gene Expression Regulation Of Binding Regulation Of Gene Expression Anatomical Structure Development Cellular Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Epithelium Development Negative Regulation Of Transcription, DNA-templated Regulation Of Metabolic Process Positive Regulation Of Transcription, DNA-templated Nitrogen Compound Metabolic Process Embryo Development Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Gene Expression Wnt Signaling Pathway Negative Regulation Of Gene Expression Positive Regulation Of Nucleocytoplasmic Transport Embryo Development Ending In Birth Or Egg Hatching Regulation Of Signal Transduction Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Protein Metabolic Process Biosynthetic Process Regulation Of DNA Methylation Cell Cycle Somatic Stem Cell Maintenance Regulation Of Protein Binding Anatomical Structure Morphogenesis
Tagcloud ?		biologic clustering commitment derivation deviant dissemination etiologies evasion fallopian fimbrial fn1 hgsc homeostatic incidences metastasize modules niche pax8 peg3 quiescence slug sparc speculated speculation subsistence survive thbs2 theme totally	arrays attenuated cisplatin cochlea cochlear collectively custom downstream esr1 facilitates immunoblots insights interactomes jak1 machinery mediating modulating modulation nitration otoprotective ototoxicity partners pivotal player relaying stat stat3 trolox wistar
Tagcloud (Difference) ?		biologic clustering commitment derivation deviant dissemination etiologies evasion fallopian fimbrial fn1 hgsc homeostatic incidences metastasize modules niche pax8 peg3 quiescence slug sparc speculated speculation subsistence survive thbs2 theme totally	arrays attenuated cisplatin cochlea cochlear collectively custom downstream esr1 facilitates immunoblots insights interactomes jak1 machinery mediating modulating modulation nitration otoprotective ototoxicity partners pivotal player relaying stat stat3 trolox wistar
Tagcloud (Intersection) ?