TCF21 and HOXB6

Number of citations of the paper that reports this interaction (PMID 20211142)
148

Data Source:
BioGRID (two hybrid)

		TCF21	HOXB6
Gene Name		transcription factor 21	homeobox B6
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus	Nucleus
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription Histone Deacetylase Binding BHLH Transcription Factor Binding Protein Dimerization Activity Androgen Receptor Binding E-box Binding	Sequence-specific DNA Binding Transcription Factor Activity Sequence-specific DNA Binding Poly(A) RNA Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Ureteric Bud Development Branching Involved In Ureteric Bud Morphogenesis Morphogenesis Of A Branching Structure Kidney Development Vasculature Development Transcription, DNA-templated Sex Determination Branchiomeric Skeletal Muscle Development Epithelial Cell Differentiation Glomerulus Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Lung Alveolus Development Spleen Development Embryonic Digestive Tract Morphogenesis Reproductive Structure Development Gland Development Sertoli Cell Differentiation Palate Development Lung Morphogenesis Lung Vasculature Development Bronchiole Development Diaphragm Development Respiratory System Development Negative Regulation Of Androgen Receptor Signaling Pathway Metanephric Mesenchymal Cell Differentiation Metanephric Glomerular Capillary Formation	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Anterior/posterior Pattern Specification Erythrocyte Homeostasis Embryonic Skeletal System Morphogenesis
Pathways
Drugs
Diseases
GWAS		Coronary heart disease ( 22751097 21378990)
Protein-Protein Interactions		7 interactors: APEX1 APLP1 GTF3C5 HOXB6 KLF15 LMO4 TCF3	12 interactors: ALX4 CLK3 CREBBP CSNK2B EP300 HOXB7 KRT15 PKNOX1 PLSCR1 SAT1 TCEAL1 TCF21
Entrez ID		6943	3216
HPRD ID		04493	00849
Ensembl ID		ENSG00000118526	ENSG00000108511
Uniprot IDs		O43680	P17509
PDB IDs
Enriched GO Terms of Interacting Partners?		RNA Metabolic Process Gene Expression Transcription, DNA-templated RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Organ Development Developmental Process Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process System Development Posttranscriptional Regulation Of Gene Expression Cellular Response To Organonitrogen Compound Multicellular Organismal Development Biosynthetic Process Regulation Of Gene Expression Anatomical Structure Development Regulation Of Nitrogen Compound Metabolic Process Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition Tissue Development Positive Regulation Of Transcription From RNA Polymerase II Promoter During Mitosis Cellular Response To Norepinephrine Stimulus Response To Organonitrogen Compound Transcription From RNA Polymerase II Promoter 5S Class RRNA Transcription From RNA Polymerase III Type 1 Promoter TRNA Transcription From RNA Polymerase III Promoter Axial Mesoderm Morphogenesis Response To Norepinephrine Negative Regulation Of Cellular Metabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Phase Transition Immunoglobulin V(D)J Recombination TRNA Transcription DNA Recombination Central Nervous System Development Anterior/posterior Pattern Specification Nervous System Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Axial Mesoderm Development Cellular Metabolic Process Positive Regulation Of Cell Cycle Regulation Of Transcription, DNA-templated Anatomical Structure Morphogenesis B Cell Lineage Commitment Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process	N-terminal Peptidyl-lysine Acetylation Transcription, DNA-templated RNA Biosynthetic Process Anatomical Structure Morphogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter N-terminal Protein Amino Acid Acetylation Positive Regulation Of Transcription, DNA-templated RNA Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Positive Regulation Of Gene Expression Regulation Of Androgen Receptor Signaling Pathway Gene Expression Positive Regulation Of Cellular Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Cellular Macromolecule Biosynthetic Process Regulation Of Gene Expression Anatomical Structure Development Positive Regulation Of Cellular Metabolic Process N-terminal Protein Amino Acid Modification Regulation Of Nitrogen Compound Metabolic Process Macromolecule Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Cellular Response To Heat Epithelium Development Embryo Development Developmental Process Nitrogen Compound Metabolic Process Embryonic Morphogenesis Anterior/posterior Pattern Specification Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Tube Development Immune System Process Regulation Of Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Muscle Organ Development Regulation Of DNA-templated Transcription In Response To Stress Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Negative Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Heat Positive Regulation Of Metabolic Process Embryonic Organ Morphogenesis Histone H2B Acetylation
Tagcloud ?		biologic clustering commitment derivation deviant dissemination etiologies evasion fallopian fimbrial fn1 hgsc homeostatic incidences metastasize modules niche pax8 peg3 quiescence slug sparc speculated speculation subsistence survive thbs2 theme totally	11q23 amls blockade cbfbeta encode enforced eto granulocytic granulocytopoiesis granulopoiesis hematopoiesis hl60 homeobox implies leukemic leukemogenesis maturation mll monocytic monocytopoiesis morphogenic myeloblastic myh11 nb4 phases promyelocytic rearrangements transiently translocations
Tagcloud (Difference) ?		biologic clustering commitment derivation deviant dissemination etiologies evasion fallopian fimbrial fn1 hgsc homeostatic incidences metastasize modules niche pax8 peg3 quiescence slug sparc speculated speculation subsistence survive thbs2 theme totally	11q23 amls blockade cbfbeta encode enforced eto granulocytic granulocytopoiesis granulopoiesis hematopoiesis hl60 homeobox implies leukemic leukemogenesis maturation mll monocytic monocytopoiesis morphogenic myeloblastic myh11 nb4 phases promyelocytic rearrangements transiently translocations
Tagcloud (Intersection) ?