FFAR1 and GNAQ

Number of citations of the paper that reports this interaction (PMID 12629551)
160

Data Source:
HPRD (in vivo)

		FFAR1	GNAQ
Gene Name		free fatty acid receptor 1	guanine nucleotide binding protein (G protein), q polypeptide
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane	Cytoplasm Lysosomal Membrane Heterotrimeric G-protein Complex Plasma Membrane Nuclear Membrane Extracellular Vesicular Exosome
	Molecular Function	G-protein Coupled Receptor Activity Guanyl-nucleotide Exchange Factor Activity Lipid Binding Bioactive Lipid Receptor Activity	GTPase Activity Signal Transducer Activity GTPase Activator Activity Protein Binding GTP Binding G-protein Beta/gamma-subunit Complex Binding Type 2A Serotonin Receptor Binding Metal Ion Binding
	Biological Process	Energy Reserve Metabolic Process G-protein Coupled Receptor Signaling Pathway Insulin Secretion Glucose Homeostasis Positive Regulation Of GTPase Activity Small Molecule Metabolic Process Regulation Of Insulin Secretion Positive Regulation Of Calcium Ion Transport Response To Fatty Acid	Skeletal System Development Action Potential Negative Regulation Of Protein Kinase Activity Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Activation Of Phospholipase C Activity Glutamate Receptor Signaling Pathway Heart Development Blood Coagulation Post-embryonic Development Neuron Remodeling Forebrain Neuron Development Platelet Activation Regulation Of Catenin Import Into Nucleus Maternal Behavior Embryonic Digit Morphogenesis Positive Regulation Of GTPase Activity Regulation Of Melanocyte Differentiation Developmental Pigmentation Protein Stabilization Phospholipase C-activating Dopamine Receptor Signaling Pathway
Pathways		G alpha (q) signalling events Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Signaling by GPCR Integration of energy metabolism Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) Class A/1 (Rhodopsin-like receptors) Regulation of insulin secretion GPCR ligand binding Metabolic disorders of biological oxidation enzymes G alpha (q) signalling events GPCR downstream signaling Peptide hormone metabolism Gastrin-CREB signalling pathway via PKC and MAPK Free fatty acid receptors Free fatty acids regulate insulin secretion Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) Incretin synthesis, secretion, and inactivation	G alpha (q) signalling events Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Signaling by GPCR ADP signalling through P2Y purinoceptor 1 Integration of energy metabolism Regulation of insulin secretion Signal amplification Thrombin signalling through proteinase activated receptors (PARs) G alpha (q) signalling events GPCR downstream signaling Acetylcholine regulates insulin secretion Gastrin-CREB signalling pathway via PKC and MAPK Thromboxane signalling through TP receptor Platelet activation, signaling and aggregation Free fatty acids regulate insulin secretion
Drugs		Icosapent
Diseases
GWAS
Protein-Protein Interactions		2 interactors: GNAI1 GNAQ	48 interactors: ADHFE1 ADRA1B ADRBK1 AIP AKAP13 BDKRB1 BTK CCR5 CHRM3 CRHR1 CYTH1 CYTH2 FFAR1 FFAR2 GALR2 GRM2 GRM4 GRM7 HTR2A HTR2B HTR2C HTR6 KDR LUM MRGPRX1 NT5C3A PIK3CA PLCB1 PLCB2 PPT1 PTGIR RGS13 RGS16 RGS18 RGS2 RGS4 RGS5 RGS7 RIC8A RIC8B S1PR2 S1PR3 SLC9A3R1 TBXA2R TSHR TTC1 TUB VIPR1
Entrez ID		2864	2776
HPRD ID		04822	02998
Ensembl ID		ENSG00000126266
Uniprot IDs		O14842	P50148
PDB IDs
Enriched GO Terms of Interacting Partners?		Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Platelet Activation Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Wound Healing Phospholipase C-activating Dopamine Receptor Signaling Pathway Neuron Remodeling Cell Activation Response To Wounding Regulation Of Melanocyte Differentiation Maternal Behavior Regulation Of Catenin Import Into Nucleus Regulation Of Developmental Pigmentation G-protein Coupled Receptor Signaling Pathway Neuron Maturation Dopamine Receptor Signaling Pathway Forebrain Neuron Development Activation Of Phospholipase C Activity Vesicle Fusion Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Phospholipase C Activity Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Forebrain Neuron Differentiation Glutamate Receptor Signaling Pathway Developmental Pigmentation Embryonic Digit Morphogenesis Organelle Fusion Positive Regulation Of Phospholipase Activity Forebrain Generation Of Neurons Regulation Of Phospholipase Activity Action Potential Positive Regulation Of Lipase Activity Protein Stabilization Central Nervous System Neuron Development Pigmentation Membrane Fusion Regulation Of Protein Stability Regulation Of Epithelial Cell Differentiation Post-embryonic Development Cell Maturation Embryonic Limb Morphogenesis Regulation Of Protein Import Into Nucleus Limb Morphogenesis Regulation Of Protein Localization To Nucleus Limb Development Vesicle Organization Cell Surface Receptor Signaling Pathway	G-protein Coupled Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Regulation Of Catalytic Activity G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Positive Regulation Of Catalytic Activity Cell-cell Signaling Signal Transduction Signaling Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Regulation Of Signaling Cell Communication Positive Regulation Of Hydrolase Activity Positive Regulation Of GTPase Activity Positive Regulation Of Metabolic Process Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of GTPase Activity Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Termination Of G-protein Coupled Receptor Signaling Pathway Termination Of Signal Transduction Cellular Response To Stimulus Regulation Of Phosphorus Metabolic Process Positive Regulation Of Cytosolic Calcium Ion Concentration Response To Stimulus Regulation Of Signal Transduction Single-organism Behavior Regulation Of Cellular Process Chemical Homeostasis Behavior Learning Or Memory Cytosolic Calcium Ion Homeostasis Cognition Calcium Ion Homeostasis Regulation Of Metabolic Process Ion Homeostasis Cellular Ion Homeostasis Synaptic Transmission Regulation Of Secretion Neurological System Process Cellular Chemical Homeostasis Cellular Calcium Ion Homeostasis Learning Cellular Cation Homeostasis Serotonin Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Regulation Of Phospholipase Activity Metal Ion Homeostasis Regulation Of MAPK Cascade Positive Regulation Of Phosphatidylinositol Biosynthetic Process Homeostatic Process Negative Regulation Of Signaling
Tagcloud ?		accumulation agonists benefits chemicals clarify considering decreases diminished downregulated exerts expressions fatty gw9508 hairpin hepatic hepatoma hepg2 hfd knockdown lentiviral lipid lipogenesis oleic p38 srebp1 steatosis sterol utilized vectors	adaptor contributing driving extensively flies gna11 gpcrs gq guan hippo lats1 malignancy mammals melanoma mob1 mst1 ocular oncogenes oncotarget opportunity persistently phosphorylates represents sav1 taz team uveal ww45 yap
Tagcloud (Difference) ?		accumulation agonists benefits chemicals clarify considering decreases diminished downregulated exerts expressions fatty gw9508 hairpin hepatic hepatoma hepg2 hfd knockdown lentiviral lipid lipogenesis oleic p38 srebp1 steatosis sterol utilized vectors	adaptor contributing driving extensively flies gna11 gpcrs gq guan hippo lats1 malignancy mammals melanoma mob1 mst1 ocular oncogenes oncotarget opportunity persistently phosphorylates represents sav1 taz team uveal ww45 yap
Tagcloud (Intersection) ?