FFAR1 and GNAQ

Number of citations of the paper that reports this interaction (PubMedID 12629551)
0

Data Source:
HPRD (in vivo)

		FFAR1	GNAQ
Description		free fatty acid receptor 1	G protein subunit alpha q
Image
GO Annotations	Cellular Component	Plasma Membrane Membrane	Photoreceptor Outer Segment Nucleus Cytoplasm Lysosomal Membrane Golgi Apparatus Heterotrimeric G-protein Complex Plasma Membrane Membrane Nuclear Membrane Extracellular Exosome Postsynaptic Cytosol
	Molecular Function	G Protein-coupled Receptor Activity Lipid Binding Bioactive Lipid Receptor Activity	Nucleotide Binding G Protein-coupled Receptor Binding GTPase Activity G Protein Activity GTPase Activator Activity Protein Binding GTP Binding Hydrolase Activity Guanyl Nucleotide Binding Enzyme Regulator Activity G-protein Beta/gamma-subunit Complex Binding Metal Ion Binding
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Insulin Secretion Positive Regulation Of Insulin Secretion Negative Regulation Of Interleukin-1 Beta Production Glucose Homeostasis Positive Regulation Of Calcium Ion Transport Response To Fatty Acid Ligand-gated Ion Channel Signaling Pathway	Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Glutamate Receptor Signaling Pathway Phospholipase C-activating Serotonin Receptor Signaling Pathway G Protein-coupled Acetylcholine Receptor Signaling Pathway Glutamate Receptor Signaling Pathway Neuropeptide Signaling Pathway Blood Coagulation Phototransduction, Visible Light Entrainment Of Circadian Clock Hormone-mediated Signaling Pathway Regulation Of Platelet Activation Response To Prostaglandin E Protein Stabilization Regulation Of Canonical Wnt Signaling Pathway Cellular Response To Acidic PH Adenylate Cyclase-activating G Protein-coupled CAMP Receptor Signaling Pathway
Pathways		Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) G alpha (q) signalling events Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Free fatty acid receptors	PLC beta mediated events PLC beta mediated events G-protein activation Acetylcholine regulates insulin secretion Acetylcholine regulates insulin secretion G alpha (q) signalling events G alpha (q) signalling events ADP signalling through P2Y purinoceptor 1 ADP signalling through P2Y purinoceptor 1 Thromboxane signalling through TP receptor Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Thrombin signalling through proteinase activated receptors (PARs) Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells
Drugs		Icosapent
Diseases
GWAS			Bipolar disorder ( 31043756) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098)
Interacting Genes		2 interacting genes: GNAI1 GNAQ	48 interacting genes: ADHFE1 ADRA1B AIP AKAP13 BDKRB1 BTK CCR5 CHRM3 CRHR1 CYTH1 CYTH2 FFAR1 FFAR2 GALR2 GRK2 GRM2 GRM4 GRM7 HTR2A HTR2B HTR2C HTR6 KDR LUM MRGPRX1 NHERF1 NT5C3A PIK3CA PLCB1 PLCB2 PPT1 PTGIR RGS13 RGS16 RGS18 RGS2 RGS4 RGS5 RGS7 RIC8A RIC8B S1PR2 S1PR3 TBXA2R TSHR TTC1 TUB VIPR1
Entrez ID		2864	2776
HPRD ID		04822	02998
Ensembl ID		ENSG00000126266	ENSG00000156052
Uniprot IDs		O14842	A0A024R240 P50148
PDB IDs		4PHU 5KW2 5TZR 5TZY 8EIT 8EJC 8EJK 8T3V 9K1C	6VU5 7EZM 7F6G 7F6H 7F6I 7F8W 7W3Z 7W40 7XOW 8G59 8IA7 8IYS 8J9N 8JPB 8JPC 8JPE 8SZG 8UQN 8UQO 8XGO 8XGS 8Y52 8ZJD 8ZJE 9K27
Enriched GO Terms of Interacting Partners?		Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding G Protein-coupled Serotonin Receptor Signaling Pathway Response To Prostaglandin E Heterotrimeric G-protein Complex G Protein-coupled Receptor Binding G Protein Activity Neuropeptide Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Response To Ketone Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Response To Alcohol D2 Dopamine Receptor Binding GTPase Activity Positive Regulation Of Relaxation Of Smooth Muscle G Protein-coupled Serotonin Receptor Binding Lysosomal Membrane Adenylate Cyclase Inhibitor Activity GTP Binding Adenylate Cyclase Regulator Activity Adenylate Cyclase-activating G Protein-coupled CAMP Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Glutamate Receptor Signaling Pathway Positive Regulation Of Protein Localization To Cell Cortex Phospholipase C-activating Serotonin Receptor Signaling Pathway Regulation Of Protein Localization To Cell Cortex Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway Response To Hormone Phototransduction, Visible Light Cellular Response To Forskolin Regulation Of Relaxation Of Muscle G Protein-coupled Glutamate Receptor Signaling Pathway Response To Forskolin G Protein-coupled Receptor Signaling Pathway Response To Lipid Cellular Response To Acidic PH Positive Regulation Of Cholesterol Biosynthetic Process G Protein-coupled Acetylcholine Receptor Signaling Pathway Detection Of Visible Light Response To Acidic PH Positive Regulation Of Cholesterol Metabolic Process Postsynaptic Cytosol Cellular Response To PH Entrainment Of Circadian Clock Enzyme Regulator Activity Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Steroid Biosynthetic Process T Cell Migration Response To PH Negative Regulation Of Insulin Secretion Regulation Of Mitotic Spindle Organization	G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Activity Signal Transduction Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Plasma Membrane Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Cell Communication Regulation Of Signaling Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger G-protein Alpha-subunit Binding Regulation Of Signal Transduction Positive Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Biological Quality System Process Serotonin Receptor Signaling Pathway Release Of Sequestered Calcium Ion Into Cytosol Negative Regulation Of Sequestering Of Calcium Ion Positive Regulation Of Phosphatidylinositol Biosynthetic Process Gq/11-coupled Serotonin Receptor Activity Serotonin Receptor Activity Membrane G Protein-coupled Serotonin Receptor Activity Cell-cell Signaling Regulation Of Amine Transport Regulation Of Sequestering Of Calcium Ion G Protein-coupled Serotonin Receptor Complex Signaling Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Neurotransmitter Receptor Activity Cell Communication Calcium Ion Transmembrane Import Into Cytosol Regulation Of System Process G Protein-coupled Serotonin Receptor Signaling Pathway Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Muscle System Process GTPase Activator Activity Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity Regulation Of Transport Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Secretion Phospholipase C-activating Serotonin Receptor Signaling Pathway Muscle Contraction Adenylate Cyclase-inhibiting G Protein-coupled Glutamate Receptor Signaling Pathway Chemical Synaptic Transmission Serotonin Binding Guanyl-nucleotide Exchange Factor Activity Regulation Of Secretion By Cell
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