FFAR1

Name	free fatty acid receptor 1
Structure
Interactors	2 interactors: GNAI1 GNAQ
GO Annotations	Cellular Component	Plasma Membrane Membrane
	Molecular Function	G Protein-coupled Receptor Activity Lipid Binding Bioactive Lipid Receptor Activity
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Insulin Secretion Positive Regulation Of Insulin Secretion Negative Regulation Of Interleukin-1 Beta Production Glucose Homeostasis Positive Regulation Of Calcium Ion Transport Response To Fatty Acid Ligand-gated Ion Channel Signaling Pathway
Pathways	Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) G alpha (q) signalling events Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Free fatty acid receptors
Drugs	Icosapent
GWAS	No GWAS studies recorded
Entrez ID	2864
HPRD ID	04822
Ensembl ID	ENSG00000126266
Uniprot IDs	O14842
PDB IDs	4PHU 5KW2 5TZR 5TZY 8EIT 8EJC 8EJK 8T3V 9K1C
GO Terms Enriched among Interactors ?	Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding G Protein-coupled Serotonin Receptor Signaling Pathway Response To Prostaglandin E Heterotrimeric G-protein Complex G Protein-coupled Receptor Binding G Protein Activity Neuropeptide Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Response To Ketone Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Response To Alcohol D2 Dopamine Receptor Binding GTPase Activity Positive Regulation Of Relaxation Of Smooth Muscle G Protein-coupled Serotonin Receptor Binding Lysosomal Membrane Adenylate Cyclase Inhibitor Activity GTP Binding Adenylate Cyclase Regulator Activity Adenylate Cyclase-activating G Protein-coupled CAMP Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Glutamate Receptor Signaling Pathway Positive Regulation Of Protein Localization To Cell Cortex Phospholipase C-activating Serotonin Receptor Signaling Pathway Regulation Of Protein Localization To Cell Cortex Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway Response To Hormone Phototransduction, Visible Light Cellular Response To Forskolin Regulation Of Relaxation Of Muscle G Protein-coupled Glutamate Receptor Signaling Pathway Response To Forskolin G Protein-coupled Receptor Signaling Pathway Response To Lipid Cellular Response To Acidic PH Positive Regulation Of Cholesterol Biosynthetic Process G Protein-coupled Acetylcholine Receptor Signaling Pathway Detection Of Visible Light Response To Acidic PH Positive Regulation Of Cholesterol Metabolic Process Postsynaptic Cytosol Cellular Response To PH Entrainment Of Circadian Clock Enzyme Regulator Activity Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Steroid Biosynthetic Process T Cell Migration Response To PH Negative Regulation Of Insulin Secretion Regulation Of Mitotic Spindle Organization