FFAR1

Gene Name		free fatty acid receptor 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	G-protein Coupled Receptor Activity Guanyl-nucleotide Exchange Factor Activity Lipid Binding Bioactive Lipid Receptor Activity
	Biological Process	Energy Reserve Metabolic Process G-protein Coupled Receptor Signaling Pathway Insulin Secretion Glucose Homeostasis Positive Regulation Of GTPase Activity Small Molecule Metabolic Process Regulation Of Insulin Secretion Positive Regulation Of Calcium Ion Transport Response To Fatty Acid
Pathways		G alpha (q) signalling events Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Signaling by GPCR Integration of energy metabolism Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) Class A/1 (Rhodopsin-like receptors) Regulation of insulin secretion GPCR ligand binding Metabolic disorders of biological oxidation enzymes G alpha (q) signalling events GPCR downstream signaling Peptide hormone metabolism Gastrin-CREB signalling pathway via PKC and MAPK Free fatty acid receptors Free fatty acids regulate insulin secretion Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) Incretin synthesis, secretion, and inactivation
Drugs		Icosapent
Diseases
GWAS
Protein-protein Interactions		2 interactors: GNAI1 GNAQ
Entrez ID		2864
HPRD ID		04822
Ensembl ID		ENSG00000126266
Uniprot IDs		O14842
PDB IDs
Enriched GO Terms of Interacting Partners?		Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Platelet Activation Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Wound Healing Phospholipase C-activating Dopamine Receptor Signaling Pathway Neuron Remodeling Cell Activation Response To Wounding Regulation Of Melanocyte Differentiation Maternal Behavior Regulation Of Catenin Import Into Nucleus Regulation Of Developmental Pigmentation G-protein Coupled Receptor Signaling Pathway Neuron Maturation Dopamine Receptor Signaling Pathway Forebrain Neuron Development Activation Of Phospholipase C Activity Vesicle Fusion Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Phospholipase C Activity Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Forebrain Neuron Differentiation Glutamate Receptor Signaling Pathway Developmental Pigmentation Embryonic Digit Morphogenesis Organelle Fusion Positive Regulation Of Phospholipase Activity Forebrain Generation Of Neurons Regulation Of Phospholipase Activity Action Potential Positive Regulation Of Lipase Activity Protein Stabilization Central Nervous System Neuron Development Pigmentation Membrane Fusion Regulation Of Protein Stability Regulation Of Epithelial Cell Differentiation Post-embryonic Development Cell Maturation Embryonic Limb Morphogenesis Regulation Of Protein Import Into Nucleus Limb Morphogenesis Regulation Of Protein Localization To Nucleus Limb Development Vesicle Organization Cell Surface Receptor Signaling Pathway
Tagcloud ?		accumulation agonists benefits chemicals clarify considering decreases diminished downregulated exerts expressions fatty gw9508 hairpin hepatic hepatoma hepg2 hfd knockdown lentiviral lipid lipogenesis oleic p38 srebp1 steatosis sterol utilized vectors