KCTD1 and POLR1C

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		KCTD1	POLR1C
Gene Name		potassium channel tetramerization domain containing 1	polymerase (RNA) I polypeptide C, 30kDa
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus	Nucleoplasm DNA-directed RNA Polymerase III Complex DNA-directed RNA Polymerase I Complex Cytosol
	Molecular Function	Transcription Corepressor Activity Transcription Factor Binding	RNA Polymerase I Activity RNA Polymerase III Activity DNA Binding DNA-directed RNA Polymerase Activity Protein Dimerization Activity
	Biological Process	Transcription, DNA-templated Negative Regulation Of Transcription, DNA-templated Protein Homooligomerization	Transcription From RNA Polymerase I Promoter Transcription Initiation From RNA Polymerase I Promoter Transcription Elongation From RNA Polymerase I Promoter Termination Of RNA Polymerase I Transcription Transcription From RNA Polymerase III Promoter Transcription Elongation From RNA Polymerase III Promoter Termination Of RNA Polymerase III Transcription Gene Expression Positive Regulation Of Type I Interferon Production Regulation Of Gene Expression, Epigenetic Innate Immune Response Negative Regulation Of Gene Expression, Epigenetic
Pathways			RNA Polymerase III Transcription Initiation RNA Polymerase III Transcription RNA Polymerase III Transcription Initiation From Type 3 Promoter RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase I Chain Elongation RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription RNA Polymerase I Transcription RNA Polymerase I Transcription Initiation RNA Polymerase I Transcription Termination RNA Polymerase I Promoter Escape RNA Polymerase I Promoter Clearance Cytosolic sensors of pathogen-associated DNA Epigenetic regulation of gene expression Negative epigenetic regulation of rRNA expression RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Termination NoRC negatively regulates rRNA expression RNA Polymerase III Abortive And Retractive Initiation RNA Polymerase III Chain Elongation Innate Immune System
Drugs
Diseases
GWAS		Sudden cardiac arrest ( 21658281)
Protein-Protein Interactions		13 interactors: EPM2AIP1 EXOSC1 KCTD15 LMO3 LNX1 POLR1C PRKAA2 PSMA1 SDCBP TRAPPC2B UBE2I WDYHV1 ZBTB25	32 interactors: ATRIP BIRC7 CCDC33 CCDC36 CD3EAP CLU CORO1A CORO1B FAM154A FAM208B IKZF3 KCTD1 KRT19 LZTS2 MBIP MYD88 MYO5B NFKBIB NME1 POLR1D POLR1E POLR2J PPP2R3C RIMBP3 SMN2 TCF4 TNFAIP1 TRIM27 TRIOBP TSC22D4 VIM WRN
Entrez ID		284252	9533
HPRD ID		11059	09661
Ensembl ID		ENSG00000134504	ENSG00000171453
Uniprot IDs		J3KQT5 Q719H9	O15160
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Positive Regulation Of Glucocorticoid Receptor Signaling Pathway Positive Regulation Of SUMO Transferase Activity Cellular Macromolecule Catabolic Process Regulation Of Generation Of Precursor Metabolites And Energy Catabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Positive Regulation Of Extracellular Vesicular Exosome Assembly Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Transferase Activity Cellular Protein Catabolic Process Positive Regulation Of Glycogen (starch) Synthase Activity Protein Ubiquitination Regulation Of Carbohydrate Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Extracellular Vesicular Exosome Assembly Protein Modification By Small Protein Conjugation Protein Catabolic Process Gene Expression	Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of Type I Interferon Production Cytoskeleton Organization DNA-templated Transcription, Elongation Cellular Component Assembly Termination Of RNA Polymerase I Transcription Transcription Elongation From RNA Polymerase I Promoter DNA-templated Transcription, Initiation Transcription Initiation From RNA Polymerase I Promoter Response To Stress Actin Filament-based Process Transcription From RNA Polymerase I Promoter Regulation Of Type I Interferon Production Organelle Organization Innate Immune Response Regulation Of Cytokine Production Nucleobase-containing Compound Metabolic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Heterocycle Metabolic Process Actin Cytoskeleton Organization Cellular Aromatic Compound Metabolic Process Positive Regulation Of Cytokine Production Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Immune Response Immune System Process DNA-templated Transcription, Termination Cellular Nitrogen Compound Metabolic Process Regulation Of Gene Expression, Epigenetic Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Transcription, DNA-templated Negative Regulation Of Actin Nucleation Response To Stimulus Regulation Of Apoptotic Process RNA Biosynthetic Process Termination Of RNA Polymerase III Transcription Transcription Elongation From RNA Polymerase III Promoter Regulation Of Metabolic Process Regulation Of Tumor Necrosis Factor Production Regulation Of Cell Death Glial Cell Development Biosynthetic Process Nitrogen Compound Metabolic Process RRNA Transcription Cellular Process Actin Filament Organization Regulation Of Actin Nucleation RNA Metabolic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Immune System Process
Tagcloud ?			add biosynthesis burgeoning codified codifies collins constituent crest disrupts elucidating genetics hemizygous heterozygosity illustrating implicates nascent neuroepithelium pathophysiology planning playing researchers ribosome tcof1 tcs treacher treacle underpinnings utilizing
Tagcloud (Difference) ?			add biosynthesis burgeoning codified codifies collins constituent crest disrupts elucidating genetics hemizygous heterozygosity illustrating implicates nascent neuroepithelium pathophysiology planning playing researchers ribosome tcof1 tcs treacher treacle underpinnings utilizing
Tagcloud (Intersection) ?