KCTD1 and EXOSC1

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		KCTD1	EXOSC1
Gene Name		potassium channel tetramerization domain containing 1	exosome component 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus	Nuclear Exosome (RNase Complex) Exosome (RNase Complex) Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol
	Molecular Function	Transcription Corepressor Activity Transcription Factor Binding	RNA Binding Exoribonuclease Activity Protein Binding
	Biological Process	Transcription, DNA-templated Negative Regulation Of Transcription, DNA-templated Protein Homooligomerization	Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay RRNA Processing Gene Expression Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay
Pathways			Regulation of mRNA stability by proteins that bind AU-rich elements KSRP destabilizes mRNA mRNA decay by 3' to 5' exoribonuclease ATF4 activates genes Tristetraprolin (TTP) destabilizes mRNA PERK regulates gene expression Unfolded Protein Response (UPR) Deadenylation-dependent mRNA decay Butyrate Response Factor 1 (BRF1) destabilizes mRNA
Drugs
Diseases
GWAS		Sudden cardiac arrest ( 21658281)
Protein-Protein Interactions		13 interactors: EPM2AIP1 EXOSC1 KCTD15 LMO3 LNX1 POLR1C PRKAA2 PSMA1 SDCBP TRAPPC2B UBE2I WDYHV1 ZBTB25	21 interactors: A2M APP CDC37 ECSIT EXOC6 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC8 EXOSC9 KCTD1 MAST1 NOS3 NUP160 PAK7 REL RNF32 TCF4 UPF2 XRN1
Entrez ID		284252	51013
HPRD ID		11059	16223
Ensembl ID		ENSG00000134504
Uniprot IDs		J3KQT5 Q719H9	Q9Y3B2
PDB IDs			2NN6
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Positive Regulation Of Glucocorticoid Receptor Signaling Pathway Positive Regulation Of SUMO Transferase Activity Cellular Macromolecule Catabolic Process Regulation Of Generation Of Precursor Metabolites And Energy Catabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Positive Regulation Of Extracellular Vesicular Exosome Assembly Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Transferase Activity Cellular Protein Catabolic Process Positive Regulation Of Glycogen (starch) Synthase Activity Protein Ubiquitination Regulation Of Carbohydrate Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Extracellular Vesicular Exosome Assembly Protein Modification By Small Protein Conjugation Protein Catabolic Process Gene Expression	Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process RNA Catabolic Process RRNA Metabolic Process MRNA Metabolic Process RRNA Processing Aromatic Compound Catabolic Process Ribosome Biogenesis RNA Phosphodiester Bond Hydrolysis, Exonucleolytic Nuclear MRNA Surveillance DNA Deamination RNA Surveillance NcRNA Metabolic Process RNA Metabolic Process Ribonucleoprotein Complex Biogenesis Cellular Macromolecule Catabolic Process Gene Expression RNA Phosphodiester Bond Hydrolysis Cellular Nitrogen Compound Metabolic Process Nucleic Acid Phosphodiester Bond Hydrolysis Catabolic Process Nucleobase-containing Compound Metabolic Process Nitrogen Compound Metabolic Process Cellular Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Metabolic Process Histone MRNA Catabolic Process RRNA Catabolic Process DNA Modification Establishment Of Localization In Cell Histone MRNA Metabolic Process Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Immune System Process Cellular Localization Regulation Of Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Apoptotic Signaling Pathway Nucleocytoplasmic Transport Nuclear Transport Regulation Of Growth MRNA Export From Nucleus Platelet Degranulation Smooth Muscle Hyperplasia Synaptic Growth At Neuromuscular Junction Catenin Import Into Nucleus Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Complement Activation, Lectin Pathway
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