GNAZ and RAP1GAP

Number of citations of the paper that reports this interaction (PMID 10593970)
14

Data Source:
BioGRID (pull down)
HPRD (in vitro, two hybrid)

		GNAZ	RAP1GAP
Gene Name		guanine nucleotide binding protein (G protein), alpha z polypeptide	RAP1 GTPase activating protein
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Envelope Endoplasmic Reticulum Cytosol Heterotrimeric G-protein Complex Plasma Membrane Extracellular Vesicular Exosome	Golgi Membrane Cytosol Membrane
	Molecular Function	GTPase Activity Signal Transducer Activity Receptor Signaling Protein Activity GTP Binding G-protein Beta/gamma-subunit Complex Binding G-protein Coupled Serotonin Receptor Binding Metal Ion Binding	GTPase Activity GTPase Activator Activity Protein Binding Ras GTPase Binding Protein Homodimerization Activity Rap GTPase Activator Activity
	Biological Process	G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Intracellular Signal Transduction	Signal Transduction Metabolic Process Regulation Of Ras GTPase Activity Positive Regulation Of Rap GTPase Activity Negative Regulation Of Microvillus Assembly
Pathways		Signaling by GPCR GPCR downstream signaling PLC beta mediated events G alpha (s) signalling events G-protein activation Opioid Signalling G alpha (z) signalling events G alpha (i) signalling events G-protein mediated events	Rap1 signalling Adaptive Immune System
Drugs
Diseases
GWAS		Height ( 18391951)	Liver enzyme levels ( 18940312)
Protein-Protein Interactions		15 interactors: ADORA1 APP DRD2 DRD5 EYA1 EYA2 NMT1 NUCB1 OPRD1 PRKCD RAP1GAP RGS10 RGS19 RGS20 RGS7	15 interactors: BRAF CDK1 CSNK1G2 DYNC1I1 GNAZ MAP1LC3B MAPK6 MEX3B MLLT4 PFN2 PLK1 PRKACA RALGDS RAP1A ZBTB12
Entrez ID		2781	5909
HPRD ID		00746	02609
Ensembl ID		ENSG00000128266	ENSG00000076864
Uniprot IDs		P19086 Q8IY73 Q8N652	P47736
PDB IDs			1SRQ 3BRW
Enriched GO Terms of Interacting Partners?		Termination Of Signal Transduction Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Positive Regulation Of Catalytic Activity Regulation Of Signaling Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Negative Regulation Of Signaling Positive Regulation Of Metabolic Process Regulation Of Signal Transduction Termination Of G-protein Coupled Receptor Signaling Pathway Regulation Of Catalytic Activity Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Hydrolase Activity Cell Surface Receptor Signaling Pathway Negative Regulation Of Signal Transduction G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Circadian Sleep/wake Cycle, Sleep Negative Regulation Of Blood Pressure Regulation Of Metabolic Process Histone Dephosphorylation Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Synaptic Transmission Phospholipase C-activating Dopamine Receptor Signaling Pathway Cellular Response To Stimulus Signal Transduction Associative Learning Response To Abiotic Stimulus Cognition Signaling Regulation Of Systemic Arterial Blood Pressure Synaptic Transmission, Dopaminergic Neurological System Process Cell Communication Negative Regulation Of Synaptic Transmission, Glutamatergic Adult Locomotory Behavior Apoptotic Signaling Pathway Positive Regulation Of GTPase Activity Regulation Of Receptor Activity Regulation Of Circadian Sleep/wake Cycle, Sleep Regulation Of Dephosphorylation Regulation Of GTPase Activity Positive Regulation Of Protein Dephosphorylation Negative Regulation Of Circadian Rhythm Regulation Of Cellular Amino Acid Metabolic Process Regulation Of Renal Sodium Excretion Regulation Of Cellular Process Learning Regulation Of Anion Transport Regulation Of Excretion	Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Peptidyl-serine Phosphorylation Regulation Of Synaptic Vesicle Exocytosis Positive Regulation Of Catalytic Activity Mitotic Nuclear Envelope Disassembly Regulation Of Synaptic Vesicle Transport Nuclear Envelope Disassembly Positive Regulation Of Protein Phosphorylation Protein Phosphorylation Positive Regulation Of Phosphorylation Regulation Of Neurotransmitter Secretion Activation Of MAPKK Activity Nuclear Envelope Organization Positive Regulation Of Protein Modification Process Positive Regulation Of Transferase Activity Cellular Response To Growth Factor Stimulus Activation Of Protein Kinase Activity Response To Growth Factor Regulation Of Protein Phosphorylation Regulation Of Synaptic Transmission Regulation Of Catalytic Activity Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Synaptic Vesicle Exocytosis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Rap GTPase Activity Positive Regulation Of Mitotic Cell Cycle G2/M Transition Of Mitotic Cell Cycle Nucleus Organization Positive Regulation Of Protein Metabolic Process Phosphorylation Regulation Of Protein Kinase Activity Intracellular Signal Transduction Positive Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Neurotransmitter Secretion Regulation Of Rap GTPase Activity Regulation Of Phosphorylation Regulation Of Cellular Amino Acid Metabolic Process Regulation Of Kinase Activity Negative Regulation Of Neurotransmitter Transport Regulation Of Rap Protein Signal Transduction Regulation Of Exocytosis Positive Regulation Of MAPK Cascade Fibroblast Growth Factor Receptor Signaling Pathway Establishment Of Endothelial Barrier Protein Localization To Chromosome Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Protein Kinase Activity Regulation Of Phosphorus Metabolic Process Positive Regulation Of Kinase Activity
Tagcloud ?		adbrk2 alg9 arntl dpysl2 drd3 dusp6 famine gad1 gch1 grin1 grin2b gsk3b hip1r homoeostasis hspa5 impa2 kcnq2 per3 pik3c3 pip5k2a plcg1 rgs4 shuts slc6a3 slc6a4 sybl1 synj1 timeless wfs1	autophosphorylated burst c3g crk detrimental fascin filamentous forced gradual gtpase guanine holds hyperactivation imperative irrespective labile microspikes motile n17rap1 presumed protrusions recruits releasing reverses sh3 unidentified v12rap1
Tagcloud (Difference) ?		adbrk2 alg9 arntl dpysl2 drd3 dusp6 famine gad1 gch1 grin1 grin2b gsk3b hip1r homoeostasis hspa5 impa2 kcnq2 per3 pik3c3 pip5k2a plcg1 rgs4 shuts slc6a3 slc6a4 sybl1 synj1 timeless wfs1	autophosphorylated burst c3g crk detrimental fascin filamentous forced gradual gtpase guanine holds hyperactivation imperative irrespective labile microspikes motile n17rap1 presumed protrusions recruits releasing reverses sh3 unidentified v12rap1
Tagcloud (Intersection) ?