GNAZ and RAP1GAP

Number of citations of the paper that reports this interaction (PubMedID 10593970)
0

Data Source:
BioGRID (pull down)
HPRD (two hybrid, in vitro)

		GNAZ	RAP1GAP
Description		G protein subunit alpha z	RAP1 GTPase activating protein
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GO Annotations	Cellular Component	Nuclear Envelope Cytoplasm Endoplasmic Reticulum Heterotrimeric G-protein Complex Plasma Membrane Membrane Dendrite Cell Body Synapse	Golgi Membrane Cytoplasm Early Endosome Golgi Apparatus Cytosol Membrane Axon Dendrite Neuronal Cell Body
	Molecular Function	Nucleotide Binding G Protein-coupled Receptor Binding GTPase Activity Protein Binding GTP Binding Adenylate Cyclase Inhibitor Activity Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding G Protein-coupled Serotonin Receptor Binding Metal Ion Binding	GTPase Activity GTPase Activator Activity Protein Binding GTPase Regulator Activity Small GTPase Binding Protein Homodimerization Activity
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Insulin Secretion G Protein-coupled Serotonin Receptor Signaling Pathway	Adaptive Immune Response Phagocytosis Signal Transduction Positive Regulation Of Cell-cell Adhesion Regulation Of GTPase Activity Positive Regulation Of GTPase Activity Negative Regulation Of Neuron Differentiation Positive Regulation Of Phagocytosis Regulation Of Small GTPase Mediated Signal Transduction Establishment Of Localization In Cell Cell-cell Adhesion Negative Regulation Of Microvillus Assembly Negative Regulation Of Thyroid Gland Epithelial Cell Proliferation Cellular Response To Glial Cell Derived Neurotrophic Factor
Pathways		G alpha (s) signalling events G alpha (i) signalling events G alpha (z) signalling events G alpha (z) signalling events GPER1 signaling ADORA2B mediated anti-inflammatory cytokines production	Rap1 signalling RET signaling
Drugs
Diseases
GWAS		Handedness (Left-handed vs. non-left-handed) ( 31504236) Handedness (left-handed vs. right-handed) ( 31504236) Height ( 18391951) Processed meat consumption ( 32066663)	Abdominal aortic calcification levels ( 31659325) Heel bone mineral density ( 30598549) High light scatter reticulocyte count ( 27863252 32888494) High light scatter reticulocyte percentage of red cells ( 27863252) Immature fraction of reticulocytes ( 27863252) Liver enzyme levels ( 18940312) Mean reticulocyte volume ( 32888494) Metabolite levels ( 23823483) Neurocognitive impairment in HIV-1 infection (continuous) ( 28447399) Serum alkaline phosphatase levels ( 31666285)
Interacting Genes		17 interacting genes: ADORA1 APP CFTR DRD2 DRD5 EYA1 EYA2 LRRK1 NMT1 NUCB1 OPRD1 PRKCD RAP1GAP RGS10 RGS19 RGS20 RGS7	18 interacting genes: AFDN BRAF CDK1 CSNK1G2 DSCR9 DYNC1I1 GNAZ LCOR MAP1LC3B MAPK6 MEX3B PFN2 PLK1 PRKACA RALGDS RAP1A VPS26C ZBTB12
Entrez ID		2781	5909
HPRD ID		00746	02609
Ensembl ID		ENSG00000128266	ENSG00000076864
Uniprot IDs		P19086 Q8IY73	P47736 X6R8W7
PDB IDs		8DZS	1SRQ 3BRW
Enriched GO Terms of Interacting Partners?		Regulation Of Cell Communication Regulation Of Signaling Regulation Of G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Regulation Of Signal Transduction Negative Regulation Of Cell Communication Negative Regulation Of Signaling G-protein Alpha-subunit Binding Signal Transduction Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Signal Transduction Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Regulation Of Membrane Potential Histone H2AXY142 Phosphatase Activity Negative Regulation Of Circadian Sleep/wake Cycle, Sleep Negative Regulation Of Synaptic Transmission Presynaptic Membrane Dopamine Neurotransmitter Receptor Activity Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Catalytic Activity GTPase Activity Negative Regulation Of Blood Pressure Dopamine Binding Heterotrimeric G-protein Binding Plasma Membrane Phospholipase C-activating Dopamine Receptor Signaling Pathway Mesodermal Cell Fate Specification Negative Regulation Of Synaptic Transmission, Glutamatergic Intracellular Monoatomic Cation Homeostasis Intracellular Monoatomic Ion Homeostasis Regulation Of Monoatomic Ion Transport Regulation Of Synaptic Plasticity Negative Regulation Of Long-term Synaptic Potentiation Negative Regulation Of Circadian Rhythm Dendrite Postsynaptic Membrane Adult Locomotory Behavior Monoatomic Cation Homeostasis Monoatomic Ion Homeostasis Positive Regulation Of GTPase Activity Positive Regulation Of Transport Synaptic Transmission, Dopaminergic GTPase Activator Activity Long-term Synaptic Depression Associative Learning Intracellular Chemical Homeostasis Regulation Of Postsynaptic Membrane Potential Regulation Of Establishment Of Protein Localization Positive Regulation Of Cell Communication Positive Regulation Of Signaling	Protein Phosphorylation Phosphorylation Protein Serine Kinase Activity Protein Serine/threonine Kinase Activity Protein Kinase Activity Negative Regulation Of Synaptic Vesicle Exocytosis Regulation Of Synaptic Vesicle Exocytosis Kinase Activity Phosphate-containing Compound Metabolic Process Mitotic Nuclear Membrane Disassembly Regulation Of Neurotransmitter Secretion Nuclear Membrane Disassembly Membrane Disassembly Intracellular Signaling Cassette Nucleotide Binding Positive Regulation Of Peptidyl-serine Phosphorylation Regulation Of Regulated Secretory Pathway Regulation Of Secretion By Cell Regulation Of Protein Localization Protein Localization To Site Of Double-strand Break Regulation Of Secretion Regulation Of Peptidyl-serine Phosphorylation Negative Regulation Of Secretion By Cell Postsynaptic Modulation Of Chemical Synaptic Transmission Synaptic Vesicle Exocytosis Positive Regulation Of Protein Modification Process Mitotic G2 DNA Damage Checkpoint Signaling Negative Regulation Of Exocytosis Establishment Of Endothelial Barrier Chromosome Condensation Negative Regulation Of Secretion Positive Regulation Of D-glucose Transmembrane Transport Pronuclear Fusion Spindle Microtubule Endothelial Cell Development Peptidyl-serine Phosphorylation Regulation Of Exocytosis Protein Modification Process Nuclear Membrane Organization Centrosome Cycle Sperm Midpiece Presynapse Intracellular Signal Transduction Postsynapse Positive Regulation Of Actin Filament Bundle Assembly Positive Regulation Of Protein Phosphorylation Modulation Of Chemical Synaptic Transmission MAPK Cascade ERK1 And ERK2 Cascade Positive Regulation Of Stress Fiber Assembly
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