GNAZ and DRD5

Number of citations of the paper that reports this interaction (PubMedID 9603210)
0

Data Source:
HPRD (in vivo, in vitro)

		GNAZ	DRD5
Description		G protein subunit alpha z	dopamine receptor D5
Image
GO Annotations	Cellular Component	Nuclear Envelope Cytoplasm Endoplasmic Reticulum Heterotrimeric G-protein Complex Plasma Membrane Membrane Dendrite Cell Body Synapse	Plasma Membrane Cilium Membrane Brush Border Membrane Synapse Ciliary Membrane Non-motile Cilium
	Molecular Function	Nucleotide Binding G Protein-coupled Receptor Binding GTPase Activity Protein Binding GTP Binding Adenylate Cyclase Inhibitor Activity Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding G Protein-coupled Serotonin Receptor Binding Metal Ion Binding	Dopamine Neurotransmitter Receptor Activity, Coupled Via Gs G Protein-coupled Receptor Activity Dopamine Neurotransmitter Receptor Activity Protein Binding Dopamine Binding
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Insulin Secretion G Protein-coupled Serotonin Receptor Signaling Pathway	Synaptic Transmission, Dopaminergic Response To Amphetamine Regulation Of Systemic Arterial Blood Pressure By Vasopressin Norepinephrine-epinephrine Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure Intracellular Calcium Ion Homeostasis Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway G Protein-coupled Dopamine Receptor Signaling Pathway Chemical Synaptic Transmission Mating Behavior Associative Learning Transmission Of Nerve Impulse Negative Regulation Of NAD(P)H Oxidase Activity Wound Healing Response To Cocaine Positive Regulation Of MAPK Cascade Positive Regulation Of Adenylate Cyclase Activity Negative Regulation Of Blood Pressure Regulation Of Female Receptivity Sensitization Phospholipase C-activating Dopamine Receptor Signaling Pathway Long-term Synaptic Depression Cellular Response To Catecholamine Stimulus Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Reactive Oxygen Species Metabolic Process
Pathways		G alpha (s) signalling events G alpha (i) signalling events G alpha (z) signalling events G alpha (z) signalling events GPER1 signaling ADORA2B mediated anti-inflammatory cytokines production	Dopamine receptors G alpha (s) signalling events
Drugs			Ziprasidone Cabergoline Cabergoline Olanzapine Olanzapine Loxapine Loxapine Imipramine Chlorpromazine Chlorpromazine Lamotrigine Cinnarizine Lisuride Ergotamine Apomorphine Paroxetine Trimipramine Fenoldopam Dopamine Dopamine Carphenazine Ergoloid mesylate Pergolide Bromocriptine Quetiapine Levodopa Aripiprazole Methotrimeprazine Zuclopenthixol Rotigotine Mianserin Nandrolone decanoate Quinagolide Zotepine Dihydro-alpha-ergocryptine Epicriptine Pipradrol Dihydroergocristine Aripiprazole lauroxil
Diseases
GWAS		Handedness (Left-handed vs. non-left-handed) ( 31504236) Handedness (left-handed vs. right-handed) ( 31504236) Height ( 18391951) Processed meat consumption ( 32066663)	Gut microbiota (bacterial taxa) ( 27723756) Impulsivity (motor) ( 30718321) Lung cancer ( 28604730) Manganese levels ( 26025379) Metabolite levels ( 23823483)
Interacting Genes		17 interacting genes: ADORA1 APP CFTR DRD2 DRD5 EYA1 EYA2 LRRK1 NMT1 NUCB1 OPRD1 PRKCD RAP1GAP RGS10 RGS19 RGS20 RGS7	9 interacting genes: GABRG2 GNA12 GNA13 GNAS GNAZ KRTAP1-1 NBPF19 NCS1 NOTCH2NLA
Entrez ID		2781	1816
HPRD ID		00746	00542
Ensembl ID		ENSG00000128266	ENSG00000169676
Uniprot IDs		P19086 Q8IY73	P21918
PDB IDs		8DZS	8IRV
Enriched GO Terms of Interacting Partners?		Regulation Of Cell Communication Regulation Of Signaling Regulation Of G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Regulation Of Signal Transduction Negative Regulation Of Cell Communication Negative Regulation Of Signaling G-protein Alpha-subunit Binding Signal Transduction Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Signal Transduction Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Regulation Of Membrane Potential Histone H2AXY142 Phosphatase Activity Negative Regulation Of Circadian Sleep/wake Cycle, Sleep Negative Regulation Of Synaptic Transmission Presynaptic Membrane Dopamine Neurotransmitter Receptor Activity Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Catalytic Activity GTPase Activity Negative Regulation Of Blood Pressure Dopamine Binding Heterotrimeric G-protein Binding Plasma Membrane Phospholipase C-activating Dopamine Receptor Signaling Pathway Mesodermal Cell Fate Specification Negative Regulation Of Synaptic Transmission, Glutamatergic Intracellular Monoatomic Cation Homeostasis Intracellular Monoatomic Ion Homeostasis Regulation Of Monoatomic Ion Transport Regulation Of Synaptic Plasticity Negative Regulation Of Long-term Synaptic Potentiation Negative Regulation Of Circadian Rhythm Dendrite Postsynaptic Membrane Adult Locomotory Behavior Monoatomic Cation Homeostasis Monoatomic Ion Homeostasis Positive Regulation Of GTPase Activity Positive Regulation Of Transport Synaptic Transmission, Dopaminergic GTPase Activator Activity Long-term Synaptic Depression Associative Learning Intracellular Chemical Homeostasis Regulation Of Postsynaptic Membrane Potential Regulation Of Establishment Of Protein Localization Positive Regulation Of Cell Communication Positive Regulation Of Signaling	Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding Heterotrimeric G-protein Complex D5 Dopamine Receptor Binding Rho-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Binding G Protein Activity GTPase Activity GTP Binding Regulation Of Fibroblast Migration Brush Border Membrane G Protein-coupled Receptor Signaling Pathway Rho Protein Signal Transduction Mu-type Opioid Receptor Binding Dendrite G Protein-coupled Serotonin Receptor Binding Regulation Of Cell Shape Hair Follicle Placode Formation Corticotropin-releasing Hormone Receptor 1 Binding Adenylate Cyclase Activator Activity Adenylate Cyclase-activating Serotonin Receptor Signaling Pathway Adenylate Cyclase Regulator Activity Adenylate Cyclase Inhibitor Activity Calcium Sensitive Guanylate Cyclase Activator Activity Cellular Response To Histamine Regulation Of Cell Communication Regulation Of Signaling Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Beta-2 Adrenergic Receptor Binding Regulation Of Blood Pressure Regulation Of Insulin Secretion D1 Dopamine Receptor Binding
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