GNAZ and OPRD1

Number of citations of the paper that reports this interaction (PubMedID 9166747)
0

Data Source:
HPRD (in vitro)

		GNAZ	OPRD1
Description		G protein subunit alpha z	opioid receptor delta 1
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GO Annotations	Cellular Component	Nuclear Envelope Cytoplasm Endoplasmic Reticulum Heterotrimeric G-protein Complex Plasma Membrane Membrane Dendrite Cell Body Synapse	Plasma Membrane Membrane Synaptic Vesicle Membrane Vesicle Dendrite Membrane Presynaptic Membrane Neuron Projection Axon Terminus Postsynaptic Membrane Spine Apparatus Postsynaptic Density Membrane Neuronal Dense Core Vesicle
	Molecular Function	Nucleotide Binding G Protein-coupled Receptor Binding GTPase Activity Protein Binding GTP Binding Adenylate Cyclase Inhibitor Activity Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding G Protein-coupled Serotonin Receptor Binding Metal Ion Binding	G Protein-coupled Receptor Activity G Protein-coupled Opioid Receptor Activity Protein Binding G Protein-coupled Peptide Receptor Activity Receptor Serine/threonine Kinase Binding G Protein-coupled Enkephalin Receptor Activity Neuropeptide Binding
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Insulin Secretion G Protein-coupled Serotonin Receptor Signaling Pathway	Immune Response Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Adult Locomotory Behavior Negative Regulation Of Gene Expression Negative Regulation Of Protein-containing Complex Assembly Response To Nicotine G Protein-coupled Opioid Receptor Signaling Pathway Eating Behavior Response To Ethanol Regulation Of Mitochondrial Membrane Potential Regulation Of Calcium Ion Transport Cellular Response To Growth Factor Stimulus Cellular Response To Hypoxia Cellular Response To Toxic Substance
Pathways		G alpha (s) signalling events G alpha (i) signalling events G alpha (z) signalling events G alpha (z) signalling events GPER1 signaling ADORA2B mediated anti-inflammatory cytokines production	Peptide ligand-binding receptors G alpha (i) signalling events Interleukin-4 and Interleukin-13 signaling
Drugs			Tramadol Morphine Codeine Amitriptyline Hydromorphone Methadone Oxycodone Dextromethorphan Butorphanol Dextropropoxyphene Naltrexone Sufentanil Fentanyl Loperamide Nalbuphine Levorphanol Remifentanil Buprenorphine Hydrocodone Diphenoxylate Naloxone Oxymorphone Ketamine Aripiprazole 3-Methylthiofentanyl Dimethylthiambutene Diamorphine Etorphine Carfentanil Diprenorphine Dihydromorphine 3-Methylfentanyl ADL5859 Tapentadol Nalmefene Alvimopan Amisulpride Morphine glucuronide Ketobemidone Cannabidiol Butyrfentanyl Pholcodine Eluxadoline Opium Naldemedine Samidorphan Metenkefalin Medical Cannabis Nabiximols Loxicodegol
Diseases
GWAS		Handedness (Left-handed vs. non-left-handed) ( 31504236) Handedness (left-handed vs. right-handed) ( 31504236) Height ( 18391951) Processed meat consumption ( 32066663)	Tourette syndrome ( 30818990)
Interacting Genes		17 interacting genes: ADORA1 APP CFTR DRD2 DRD5 EYA1 EYA2 LRRK1 NMT1 NUCB1 OPRD1 PRKCD RAP1GAP RGS10 RGS19 RGS20 RGS7	22 interacting genes: ADRB2 ARRB1 ARRB2 CTXN3 GNA15 GNAI1 GNAI2 GNAO1 GNAZ GPRASP1 GRK2 KLHL3 OPRK1 OPRM1 PRKCA PRKCD PRKCE RPRM SLC12A7 SLC13A4 SMAGP TMEM237
Entrez ID		2781	4985
HPRD ID		00746	01308
Ensembl ID		ENSG00000128266	ENSG00000116329
Uniprot IDs		P19086 Q8IY73	P41143
PDB IDs		8DZS	4N6H 4RWA 4RWD 6PT2 6PT3 8F7S 8Y45
Enriched GO Terms of Interacting Partners?		Regulation Of Cell Communication Regulation Of Signaling Regulation Of G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Regulation Of Signal Transduction Negative Regulation Of Cell Communication Negative Regulation Of Signaling G-protein Alpha-subunit Binding Signal Transduction Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Signal Transduction Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Regulation Of Membrane Potential Histone H2AXY142 Phosphatase Activity Negative Regulation Of Circadian Sleep/wake Cycle, Sleep Negative Regulation Of Synaptic Transmission Presynaptic Membrane Dopamine Neurotransmitter Receptor Activity Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Catalytic Activity GTPase Activity Negative Regulation Of Blood Pressure Dopamine Binding Heterotrimeric G-protein Binding Plasma Membrane Phospholipase C-activating Dopamine Receptor Signaling Pathway Mesodermal Cell Fate Specification Negative Regulation Of Synaptic Transmission, Glutamatergic Intracellular Monoatomic Cation Homeostasis Intracellular Monoatomic Ion Homeostasis Regulation Of Monoatomic Ion Transport Regulation Of Synaptic Plasticity Negative Regulation Of Long-term Synaptic Potentiation Negative Regulation Of Circadian Rhythm Dendrite Postsynaptic Membrane Adult Locomotory Behavior Monoatomic Cation Homeostasis Monoatomic Ion Homeostasis Positive Regulation Of GTPase Activity Positive Regulation Of Transport Synaptic Transmission, Dopaminergic GTPase Activator Activity Long-term Synaptic Depression Associative Learning Intracellular Chemical Homeostasis Regulation Of Postsynaptic Membrane Potential Regulation Of Establishment Of Protein Localization Positive Regulation Of Cell Communication Positive Regulation Of Signaling	G Protein-coupled Receptor Binding Guanyl Nucleotide Binding Negative Regulation Of G Protein-coupled Receptor Signaling Pathway G-protein Beta/gamma-subunit Complex Binding Heterotrimeric G-protein Complex Regulation Of G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway G Protein-coupled Serotonin Receptor Binding Postsynaptic Signal Transduction Regulation Of Transport Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway G Protein-coupled Acetylcholine Receptor Signaling Pathway Regulation Of Secretion By Cell Negative Regulation Of Secretion By Cell Desensitization Of G Protein-coupled Receptor Signaling Pathway Regulation Of Secretion Positive Regulation Of MAPK Cascade Negative Regulation Of Cell Communication Regulation Of MAPK Cascade Negative Regulation Of Signaling Negative Adaptation Of Signaling Pathway Negative Regulation Of Secretion Plasma Membrane G Protein-coupled Receptor Signaling Pathway Regulation Of System Process Acetylcholine Receptor Signaling Pathway Regulation Of Muscle System Process Negative Regulation Of Transport Regulation Of Hormone Secretion Regulation Of Protein Secretion Regulation Of Protein Transport Diacylglycerol-dependent Serine/threonine Kinase Activity Regulation Of Cell Communication Regulation Of Signaling Angiotensin Receptor Binding Negative Regulation Of Hormone Secretion Regulation Of Insulin Secretion Positive Regulation Of Superoxide Anion Generation Negative Regulation Of Protein Secretion G Protein-coupled Serotonin Receptor Signaling Pathway Regulation Of Superoxide Anion Generation Regulation Of Biological Quality Regulation Of Establishment Of Protein Localization Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Peptide Hormone Secretion System Process Regulation Of Superoxide Metabolic Process Enzyme Binding Adenylate Cyclase Inhibitor Activity Adenylate Cyclase Regulator Activity
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