GNAZ and NMT1

Number of citations of the paper that reports this interaction (PubMedID 2153964)
28

Data Source:
HPRD (in vitro)

		GNAZ	NMT1
Description		G protein subunit alpha z	N-myristoyltransferase 1
Image
GO Annotations	Cellular Component	Nuclear Envelope Cytoplasm Endoplasmic Reticulum Heterotrimeric G-protein Complex Plasma Membrane Membrane Dendrite Cell Body Synapse	Cytoplasm Cytosol Plasma Membrane Membrane
	Molecular Function	Nucleotide Binding G Protein-coupled Receptor Binding GTPase Activity Protein Binding GTP Binding Adenylate Cyclase Inhibitor Activity Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding G Protein-coupled Serotonin Receptor Binding Metal Ion Binding	Glycylpeptide N-tetradecanoyltransferase Activity Protein Binding Transferase Activity Acyltransferase Activity Peptidyl-lysine N6-myristoyltransferase Activity Myristoyltransferase Activity
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Insulin Secretion G Protein-coupled Serotonin Receptor Signaling Pathway	In Utero Embryonic Development N-terminal Peptidyl-glycine N-myristoylation Regulation Of Opsin-mediated Signaling Pathway Cellular Response To Nutrient Levels Ketone Metabolic Process Protein Localization To Membrane Positive Regulation Of Protein Localization To Lysosome Positive Regulation Of Establishment Of Protein Localization To Mitochondrion Positive Regulation Of TORC1 Signaling
Pathways		G alpha (s) signalling events G alpha (i) signalling events G alpha (z) signalling events G alpha (z) signalling events GPER1 signaling ADORA2B mediated anti-inflammatory cytokines production	Late Phase of HIV Life Cycle eNOS activation Inactivation, recovery and regulation of the phototransduction cascade Activation, myristolyation of BID and translocation to mitochondria
Drugs			(1-Methyl-1h-Imidazol-2-Yl)-(3-Methyl-4-{3-[(Pyridin-3-Ylmethyl)-Amino]-Propoxy}-Benzofuran-2-Yl)-Methanone
Diseases
GWAS		Handedness (Left-handed vs. non-left-handed) ( 31504236) Handedness (left-handed vs. right-handed) ( 31504236) Height ( 18391951) Processed meat consumption ( 32066663)	Asthma ( 31619474) Blood glucose levels ( 31928498) Brain morphology (MOSTest) ( 32665545) Craniofacial microsomia ( 26853712) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Multisite chronic pain ( 31194737 33830993) Periventricular white matter hyperintensities ( 32517579) Plateletcrit ( 32888494) Pulse pressure ( 30578418) Systolic blood pressure ( 31928498 30578418) Walking pace ( 33128006) White matter hyperintensities ( 32358547) White matter hyperintensity volume ( 33293549)
Interacting Genes		17 interacting genes: ADORA1 APP CFTR DRD2 DRD5 EYA1 EYA2 LRRK1 NMT1 NUCB1 OPRD1 PRKCD RAP1GAP RGS10 RGS19 RGS20 RGS7	14 interacting genes: ANXA13 ARL5A CABP1 CABP2 CAPN2 CSNK2A1 FYN GNAZ HPCA LYN MARCKS NOS3 SRC TP53
Entrez ID		2781	4836
HPRD ID		00746	01187
Ensembl ID		ENSG00000128266	ENSG00000136448
Uniprot IDs		P19086 Q8IY73	P30419
PDB IDs		8DZS	1RXT 3IU1 3IU2 3IWE 3JTK 4C2Y 4C2Z 5MU6 5NPQ 5O6H 5O6J 5O9S 5O9T 5O9U 5O9V 5UUT 6EHJ 6F56 6FZ2 6FZ3 6FZ5 6PAV 6QRM 6SJZ 6SK2 6SK3 6SK8 6SKJ 7OWM 7OWN 7OWO 7OWP 7OWQ 7OWR 7OWU 7RK3 8Q23 8Q24 8Q26 8Q2Z 8Q3D 8Q3S 8Q3T
Enriched GO Terms of Interacting Partners?		Regulation Of Cell Communication Regulation Of Signaling Regulation Of G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Regulation Of Signal Transduction Negative Regulation Of Cell Communication Negative Regulation Of Signaling G-protein Alpha-subunit Binding Signal Transduction Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Signal Transduction Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Regulation Of Membrane Potential Histone H2AXY142 Phosphatase Activity Negative Regulation Of Circadian Sleep/wake Cycle, Sleep Negative Regulation Of Synaptic Transmission Presynaptic Membrane Dopamine Neurotransmitter Receptor Activity Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Catalytic Activity GTPase Activity Negative Regulation Of Blood Pressure Dopamine Binding Heterotrimeric G-protein Binding Plasma Membrane Phospholipase C-activating Dopamine Receptor Signaling Pathway Mesodermal Cell Fate Specification Negative Regulation Of Synaptic Transmission, Glutamatergic Intracellular Monoatomic Cation Homeostasis Intracellular Monoatomic Ion Homeostasis Regulation Of Monoatomic Ion Transport Regulation Of Synaptic Plasticity Negative Regulation Of Long-term Synaptic Potentiation Negative Regulation Of Circadian Rhythm Dendrite Postsynaptic Membrane Adult Locomotory Behavior Monoatomic Cation Homeostasis Monoatomic Ion Homeostasis Positive Regulation Of GTPase Activity Positive Regulation Of Transport Synaptic Transmission, Dopaminergic GTPase Activator Activity Long-term Synaptic Depression Associative Learning Intracellular Chemical Homeostasis Regulation Of Postsynaptic Membrane Potential Regulation Of Establishment Of Protein Localization Positive Regulation Of Cell Communication Positive Regulation Of Signaling	Membrane Raft Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Stimulatory C-type Lectin Receptor Signaling Pathway Scaffold Protein Binding Cellular Response To Lectin Fc Receptor Mediated Stimulatory Signaling Pathway Ephrin Receptor Binding Regulation Of Cellular Localization Response To Amino Acid Negative Regulation Of Inflammatory Response To Antigenic Stimulus Fc-gamma Receptor Signaling Pathway Regulation Of Protein Localization Response To Fluid Shear Stress Non-membrane Spanning Protein Tyrosine Kinase Activity T Cell Costimulation Regulation Of Transport Ephrin Receptor Signaling Pathway Peptidyl-tyrosine Phosphorylation Regulation Of Apoptotic Signaling Pathway Enzyme Binding Fc Receptor Signaling Pathway Signaling Receptor Activator Activity Cellular Response To L-glutamate Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Negative Regulation Of Apoptotic Signaling Pathway Phospholipase Activator Activity Cellular Response To Amino Acid Stimulus Cellular Response To Oxygen-containing Compound Positive Regulation Of Protein Localization To Membrane Regulation Of Establishment Of Protein Localization Regulation Of Apoptotic Process Plasma Membrane Regulation Of Programmed Cell Death Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Response To Hydrogen Peroxide DNA Damage Checkpoint Signaling Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Cytoplasm Negative Regulation Of Cell Communication Negative Regulation Of Signaling Autophagy Calcium Ion Binding Perinuclear Endoplasmic Reticulum Cellular Response To Stress Response To L-glutamate Lymphocyte Proliferation Mononuclear Cell Proliferation Negative Regulation Of Protein Transport Phospholipase Binding Cellular Response To Platelet-derived Growth Factor Stimulus
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