S1PR2 and GNAI1

Number of citations of the paper that reports this interaction (PMID 10488065)
54

Data Source:
HPRD (in vitro)

		S1PR2	GNAI1
Gene Name		sphingosine-1-phosphate receptor 2	guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
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Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane	Nucleus Cytoplasm Lysosomal Membrane Centrosome Heterotrimeric G-protein Complex Plasma Membrane Midbody Extracellular Vesicular Exosome
	Molecular Function	G-protein Coupled Receptor Binding G-protein Coupled Receptor Activity Integrin Binding Lipid Binding Sphingosine-1-phosphate Receptor Activity	GTPase Activity Signal Transducer Activity Protein Binding GTP Binding G-protein Beta/gamma-subunit Complex Binding G-protein Coupled Serotonin Receptor Binding Metal Ion Binding
	Biological Process	Activation Of MAPK Activity Sphingosine-1-phosphate Signaling Pathway G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cell Proliferation Negative Regulation Of Excitatory Postsynaptic Membrane Potential Positive Regulation Of Establishment Of Endothelial Barrier	Cell Cycle G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Synaptic Transmission Blood Coagulation Platelet Activation Response To Peptide Hormone Cell Division
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding Lysosphingolipid and LPA receptors	Signaling by GPCR Integration of energy metabolism G alpha (s) signalling events Activation of GABAB receptors Signal amplification G alpha (z) signalling events G alpha (i) signalling events Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell ADP signalling through P2Y purinoceptor 12 GABA B receptor activation Adenylate cyclase inhibitory pathway GABA receptor activation PLC beta mediated events Opioid Signalling Regulation of insulin secretion G-protein mediated events Adrenaline,noradrenaline inhibits insulin secretion Inhibition of adenylate cyclase pathway Adenylate cyclase inhibitory pathway GPCR downstream signaling G-protein activation Platelet activation, signaling and aggregation Transmission across Chemical Synapses
Drugs
Diseases
GWAS
Protein-Protein Interactions		3 interactors: GNA13 GNAI1 GNAQ	57 interactors: ADCY5 ADRA2A CCR5 CD47 CNR1 CRHR1 CXCR4 DRD3 EPOR ESR1 FFAR1 GNAO1 GNB2 GNB4 GPR1 GPR143 GPSM1 GPSM2 GPSM3 HRH4 HTR2A IGF1R KLHL3 MTNR1A MTNR1B NGB NUCB1 NUMA1 OPRD1 OPRM1 PDE6D PTPRU RANGAP1 RASD1 RGS10 RGS12 RGS14 RGS16 RGS17 RGS18 RGS19 RGS20 RGS4 RGS7 RIC8A S1PR1 S1PR2 S1PR3 S1PR4 S1PR5 SSTR2 SSTR3 STRN THAP7 TSHR VIPR1 WASF1
Entrez ID		9294	2770
HPRD ID		05488	00756
Ensembl ID			ENSG00000127955
Uniprot IDs		O95136	P63096
PDB IDs		1ZTI	1KJY 1Y3A 2G83 2GTP 2IK8 2OM2 2PZ3 2XNS 3ONW 3QE0 3QI2 3UMR 3UMS 4G5Q
Enriched GO Terms of Interacting Partners?		Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Platelet Activation Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Wound Healing Cell Activation Response To Wounding Positive Regulation Of Phospholipase Activity Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity G-protein Coupled Receptor Signaling Pathway Phospholipase C-activating Dopamine Receptor Signaling Pathway Neuron Remodeling Regulation Of Melanocyte Differentiation Activation Of Phospholipase D Activity Maternal Behavior Cell Surface Receptor Signaling Pathway Regulation Of Catenin Import Into Nucleus Regulation Of Developmental Pigmentation Response To Stress Neuron Maturation Cardiovascular System Development Dopamine Receptor Signaling Pathway Forebrain Neuron Development Positive Regulation Of Hydrolase Activity Patterning Of Blood Vessels Activation Of Phospholipase C Activity Vesicle Fusion Embryo Development Positive Regulation Of Phospholipase C Activity Rho Protein Signal Transduction Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Forebrain Neuron Differentiation Glutamate Receptor Signaling Pathway Developmental Pigmentation Embryonic Digit Morphogenesis Organelle Fusion Forebrain Generation Of Neurons Action Potential Signal Transduction Protein Stabilization Positive Regulation Of Catalytic Activity Signaling Central Nervous System Neuron Development Cell Communication Pigmentation	G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Cell Surface Receptor Signaling Pathway Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Signal Transduction Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Signaling Cell Communication Regulation Of Catalytic Activity Termination Of G-protein Coupled Receptor Signaling Pathway Termination Of Signal Transduction Cellular Response To Stimulus Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Catalytic Activity Response To Stimulus Regulation Of Signaling Positive Regulation Of Hydrolase Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Sphingosine-1-phosphate Signaling Pathway Regulation Of Cellular Process Chemical Homeostasis Cell-cell Signaling Cytosolic Calcium Ion Homeostasis Positive Regulation Of GTPase Activity Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Regulation Of GTPase Activity Positive Regulation Of Metabolic Process Regulation Of Signal Transduction Synaptic Transmission Negative Regulation Of Signaling Behavior Cellular Metal Ion Homeostasis Neuropeptide Signaling Pathway Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Cellular Cation Homeostasis Ion Homeostasis Cellular Ion Homeostasis Homeostatic Process Metal Ion Homeostasis Negative Regulation Of Signal Transduction Cellular Chemical Homeostasis Locomotory Behavior Response To Ammonium Ion Negative Regulation Of Ion Transport Response To Cocaine Regulation Of Cell Proliferation Neurological System Process
Tagcloud ?		altogether bioactive chl contiguous dissemination fty720 functionally gi governs h2 hd1 heterotrimeric hodgkin jte013 km lymphatic lymphoma membranous neoplasm potentiated potently reed s1pr1 sphingolipid sphingosine sternberg sup vpc44116	alkenes azotic constructions gnao1 heterocycle hm hms htr1b htr2a htr2b htr4 htr6 htr7 kpnb1 pharmacopeia prkaca prkca prkcb prkcd prkce prkcg prkd1 propertied pubchem rock2 rps6ka1 rps6ka3 tlr8 tradition
Tagcloud (Difference) ?		altogether bioactive chl contiguous dissemination fty720 functionally gi governs h2 hd1 heterotrimeric hodgkin jte013 km lymphatic lymphoma membranous neoplasm potentiated potently reed s1pr1 sphingolipid sphingosine sternberg sup vpc44116	alkenes azotic constructions gnao1 heterocycle hm hms htr1b htr2a htr2b htr4 htr6 htr7 kpnb1 pharmacopeia prkaca prkca prkcb prkcd prkce prkcg prkd1 propertied pubchem rock2 rps6ka1 rps6ka3 tlr8 tradition
Tagcloud (Intersection) ?