RGS16 and GNAT1

Number of citations of the paper that reports this interaction (PubMedID 8917514)
24

Data Source:
HPRD (in vitro)

		RGS16	GNAT1
Description		regulator of G protein signaling 16	G protein subunit alpha transducin 1
Image
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Membrane	Photoreceptor Outer Segment Photoreceptor Inner Segment Cytoplasm Cytosol Heterotrimeric G-protein Complex Plasma Membrane Membrane Apical Plasma Membrane Photoreceptor Connecting Cilium Photoreceptor Outer Segment Membrane Cell Projection Neuronal Cell Body Photoreceptor Disc Membrane
	Molecular Function	GTPase Activity GTPase Activator Activity Protein Binding Calmodulin Binding	Acyl Binding Nucleotide Binding G Protein-coupled Receptor Binding GTPase Activity GTP Binding Guanyl Nucleotide Binding GDP Binding Protein Kinase Binding G-protein Beta/gamma-subunit Complex Binding Metal Ion Binding
	Biological Process	G Protein-coupled Receptor Signaling Pathway Visual Perception Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Signal Transduction Positive Regulation Of GTPase Activity	Detection Of Chemical Stimulus Involved In Sensory Perception Of Bitter Taste Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Visual Perception Phototransduction Phototransduction, Visible Light Visual Behavior Cell Population Proliferation Response To Light Stimulus Detection Of Light Stimulus Response To Light Intensity Dopamine Secretion G Protein-coupled Opsin Signaling Pathway Regulation Of Opsin-mediated Signaling Pathway Eye Photoreceptor Cell Development Retinal Cone Cell Differentiation Detection Of Light Stimulus Involved In Visual Perception Sensory Perception Of Umami Taste Negative Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Retina Development In Camera-type Eye Retinal Rod Cell Differentiation Cellular Response To Electrical Stimulus Neural Tissue Regeneration Background Adaptation
Pathways		G alpha (q) signalling events G alpha (i) signalling events G alpha (i) signalling events G alpha (z) signalling events	Activation of the phototransduction cascade Activation of the phototransduction cascade Inactivation, recovery and regulation of the phototransduction cascade Inactivation, recovery and regulation of the phototransduction cascade G alpha (i) signalling events
Drugs			Cacodylic acid Guanosine-5'-Diphosphate Tetrafluoroaluminate Ion
Diseases			Congenital stationary night blindness (CSNB), including: CSNB type 1 (CSNB1); CSNB type 2 (CSNB2); CSNB autosomal dominant (CSNBAD); Oguchi disease/ CSNB Oguchi type (CSNBO)
GWAS		Chronotype ( 26955885 27494321 30696823) Morning person ( 30696823) Morning vs. evening chronotype ( 26835600 26955885 27494321) Sleep traits (multi-trait analysis) ( 27992416)	Body mass index ( 26426971) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Extremely high intelligence ( 29520040) General cognitive ability ( 29844566) Schizophrenia ( 30285260) Sleep duration (short sleep) ( 30846698) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		14 interacting genes: CREB3L2 CSK EGFR GDE1 GNA13 GNAI1 GNAI2 GNAI3 GNAO1 GNAQ GNAT1 LYN SRC ST14	3 interacting genes: F2R RGS16 RGS9
Entrez ID		6004	2779
HPRD ID		03945	08850
Ensembl ID		ENSG00000143333	ENSG00000114349
Uniprot IDs		O15492	P11488
PDB IDs		2BT2 2IK8	3RBQ
Enriched GO Terms of Interacting Partners?		Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding Heterotrimeric G-protein Complex G Protein-coupled Receptor Binding Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway GTPase Activity Nucleotide Binding GTP Binding G Protein Activity Plasma Membrane Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway G Protein-coupled Serotonin Receptor Signaling Pathway G Protein-coupled Serotonin Receptor Binding Regulation Of ERK1 And ERK2 Cascade Membrane Protein Tyrosine Kinase Activity Adenylate Cyclase Regulator Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Regulation Of Protein Localization To Cell Periphery T Cell Costimulation Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Catalytic Activity Signaling Receptor Activator Activity Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity GDP Binding Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Positive Regulation Of Protein Localization To Cell Periphery Signal Transduction Regulation Of Cell Communication Regulation Of Protein Localization Regulation Of Signaling Phototransduction, Visible Light Regulation Of Catalytic Activity Extracellular Exosome Negative Regulation Of Cell Communication Negative Regulation Of Signaling Protein Tyrosine Kinase Activator Activity Response To Peptide Hormone Response To Hormone Ciliary Basal Body Regulation Of Protein Localization To Plasma Membrane Negative Regulation Of Protein Transport Regulation Of MAPK Cascade G Protein-coupled Acetylcholine Receptor Signaling Pathway Stimulatory C-type Lectin Receptor Signaling Pathway Cellular Response To Lectin Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis ERBB2 Signaling Pathway	Visual Perception Sensory Perception Of Light Stimulus System Process Sensory Perception Dendritic Cell Homeostasis Negative Regulation Of Renin Secretion Into Blood Stream G Protein-coupled Receptor Signaling Pathway Trans-synaptic Signaling By Endocannabinoid, Modulating Synaptic Transmission Establishment Of Synaptic Specificity At Neuromuscular Junction Regulation Of Calcium Ion Transmembrane Transport Regulation Of G Protein-coupled Receptor Signaling Pathway Dark Adaptation Nervous System Process Platelet Dense Tubular Network Regulation Of Renin Secretion Into Blood Stream Light Adaption Negative Regulation Of Glomerular Filtration Thrombin-activated Receptor Activity Regulation Of Calcium Ion Transport Connective Tissue Replacement Involved In Inflammatory Response Wound Healing Regulation Of Monoatomic Cation Transmembrane Transport GTPase Activator Activity Regulation Of Calcium Ion Export Across Plasma Membrane Regulation Of Monoatomic Ion Transmembrane Transport GTPase Activity Connective Tissue Replacement Regulation Of Glomerular Filtration Regulation Of Metal Ion Transport Thrombin-activated Receptor Signaling Pathway Trans-synaptic Signaling, Modulating Synaptic Transmission Regulation Of Monoatomic Ion Transport Glutamate Secretion Response To Light Intensity Transcription Factor TFTC Complex Renal System Process Involved In Regulation Of Systemic Arterial Blood Pressure Cell-cell Junction Maintenance G-protein Beta-subunit Binding G Protein-coupled Dopamine Receptor Signaling Pathway Positive Regulation Of Collagen Biosynthetic Process SAGA Complex Platelet Dense Granule Organization Positive Regulation Of Blood Coagulation Positive Regulation Of Rho Protein Signal Transduction Positive Regulation Of Vasoconstriction Positive Regulation Of Coagulation Positive Regulation Of Smooth Muscle Contraction G-protein Alpha-subunit Binding Negative Regulation Of Microtubule Depolymerization Response To Amphetamine Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol
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