GLI3 and GSK3A

Number of citations of the paper that reports this interaction (PubMedID 16371461)
39

Data Source:
BioGRID (enzymatic study)

		GLI3	GSK3A
Description		GLI family zinc finger 3	glycogen synthase kinase 3 alpha
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Cilium Axoneme Nuclear Speck Transcription Repressor Complex Cell Projection Ciliary Tip Ciliary Base GLI-SUFU Complex	Nucleus Cytoplasm Mitochondrion Cytosol Axon Beta-catenin Destruction Complex Neuronal Cell Body Apical Dendrite Postsynapse Proximal Dendrite
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding Double-stranded DNA Binding DNA-binding Transcription Factor Activity Protein Binding Beta-catenin Binding Zinc Ion Binding Histone Acetyltransferase Binding Mediator Complex Binding Histone Deacetylase Binding Sequence-specific DNA Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Signaling Receptor Binding Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Kinase A Catalytic Subunit Binding Tau Protein Binding Tau-protein Kinase Activity Protein Serine Kinase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Osteoblast Differentiation Metanephros Development Branching Involved In Ureteric Bud Morphogenesis In Utero Embryonic Development Kidney Development Positive Regulation Of Neuroblast Proliferation Chondrocyte Differentiation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Protein Import Into Nucleus Apoptotic Process Smoothened Signaling Pathway Pattern Specification Process Neuroblast Proliferation Axon Guidance Central Nervous System Development Brain Development Hindgut Morphogenesis Heart Development Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Regulation Of Smoothened Signaling Pathway Anatomical Structure Morphogenesis Anterior/posterior Pattern Specification Dorsal/ventral Pattern Formation Proximal/distal Pattern Formation Gene Expression Regulation Of Gene Expression Protein Processing Spinal Cord Dorsal/ventral Patterning Spinal Cord Motor Neuron Differentiation Telencephalon Development Pallium Development Subpallium Development Optic Nerve Morphogenesis Hippocampus Development Smoothened Signaling Pathway Involved In Ventral Spinal Cord Interneuron Specification Smoothened Signaling Pathway Involved In Spinal Cord Motor Neuron Cell Fate Specification Forebrain Dorsal/ventral Pattern Formation Cerebral Cortex Radial Glia-guided Migration Layer Formation In Cerebral Cortex Forebrain Radial Glial Cell Differentiation Neural Tube Development Central Nervous System Neuron Differentiation Lateral Ganglionic Eminence Cell Proliferation Melanocyte Differentiation Lung Development Embryonic Limb Morphogenesis Mammary Gland Development Forebrain Development Negative Regulation Of Chondrocyte Differentiation Positive Regulation Of Chondrocyte Differentiation T Cell Differentiation In Thymus Limb Morphogenesis Tube Development Regulation Of Cell Population Proliferation Positive Regulation Of Protein Import Into Nucleus Odontogenesis Of Dentin-containing Tooth Embryonic Digit Morphogenesis Regulation Of Apoptotic Process Camera-type Eye Development Negative Regulation Of Apoptotic Process Nose Morphogenesis Tongue Development Negative Thymic T Cell Selection Regulation Of Cell Differentiation Negative Regulation Of Neuron Differentiation Positive Regulation Of Osteoblast Differentiation Negative Regulation Of Smoothened Signaling Pathway Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Alpha-beta T Cell Differentiation Positive Regulation Of Alpha-beta T Cell Differentiation Negative Regulation Of Alpha-beta T Cell Differentiation Embryonic Digestive Tract Morphogenesis Embryonic Digestive Tract Development Developmental Growth Camera-type Eye Morphogenesis Embryonic Morphogenesis Anatomical Structure Formation Involved In Morphogenesis Neuron Fate Commitment Embryonic Neurocranium Morphogenesis Embryonic Skeletal System Morphogenesis Oligodendrocyte Differentiation Branching Morphogenesis Of An Epithelial Tube Inner Ear Development Roof Of Mouth Development Limb Development Frontal Suture Morphogenesis Lambdoid Suture Morphogenesis Sagittal Suture Morphogenesis Mammary Gland Specification Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning Artery Development Anterior Semicircular Canal Development Lateral Semicircular Canal Development Cell Differentiation Involved In Kidney Development Thymocyte Apoptotic Process Vocalization Behavior Stem Cell Proliferation Negative Regulation Of Canonical Wnt Signaling Pathway Larynx Morphogenesis Regulation Of Bone Development Negative Regulation Of Stem Cell Proliferation	Regulation Of Systemic Arterial Blood Pressure Cardiac Left Ventricle Morphogenesis Glycogen Metabolic Process Nervous System Development Insulin Receptor Signaling Pathway Negative Regulation Of Signal Transduction Positive Regulation Of Autophagy Positive Regulation Of Gene Expression Negative Regulation Of UDP-glucose Catabolic Process Regulation Of Neuron Projection Development Wnt Signaling Pathway Cell Migration Viral Protein Processing Cell Differentiation Positive Regulation Of Protein Ubiquitination Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of TOR Signaling Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To Insulin Stimulus Cellular Response To Interleukin-3 Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Neuron Apoptotic Process Negative Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Protein Catabolic Process Positive Regulation Of Heart Contraction Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of D-glucose Import Negative Regulation Of Insulin Receptor Signaling Pathway Excitatory Postsynaptic Potential Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Regulation Of Microtubule Cytoskeleton Organization Cellular Response To Lithium Ion Cellular Response To Glucocorticoid Stimulus Positive Regulation Of Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Extrinsic Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Autosome Genomic Imprinting Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitophagy Cellular Response To Oxygen-containing Compound Positive Regulation Of Amyloid-beta Formation Positive Regulation Of Protein Targeting To Mitochondrion Positive Regulation Of Establishment Of Protein Localization Negative Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Glycogen (starch) Synthase Activity
Pathways		GLI3 is processed to GLI3R by the proteasome Hedgehog 'off' state Hedgehog 'on' state GLI proteins bind promoters of Hh responsive genes to promote transcription RUNX2 regulates osteoblast differentiation	AKT phosphorylates targets in the cytosol XBP1(S) activates chaperone genes Constitutive Signaling by AKT1 E17K in Cancer Suppression of apoptosis Maturation of nucleoprotein Maturation of nucleoprotein
Drugs			Fostamatinib
Diseases		Acrocallosal syndrome; Greig cephalopolysyndactyly syndrome Pallister-Hall syndrome
GWAS		Age-related macular degeneration ( 23326517) Allergic rhinitis ( 22036096) Appendicular lean mass ( 33097823) Asthma ( 29273806) Dietary fat liking ( 32516399) Digit length ratio ( 29659830) Digit length ratio (left hand) ( 29659830) Digit length ratio (right hand) ( 29659830) Emotional recognition ( 31596458) facial morphology traits (multivariate analysis) ( 27193062) Health literacy ( 31250787) Hip index ( 34021172) Language performance in older adults (adjusted for episodic memory) ( 28577822) Liver enzyme levels (alkaline phosphatase) ( 33972514) Mean arterial pressure (alcohol consumption interaction) ( 24376456) Metabolite levels ( 23823483) middle facial morphology traits (quantitative measurement) ( 27193062) Refractive error ( 32231278) Response to resistance training (vastus lateralis fiber area change) ( 33891350)	Meat-related diet ( 32066663)
Interacting Genes		19 interacting genes: BTRC CREBBP CSNK1A1 GSK3A MED12 PRKCA RHOU SKI SMAD1 SMAD2 SMAD3 SMAD4 STK36 SUFU TAF9 TWIST1 ZIC1 ZIC2 ZIC3	76 interacting genes: AKAP11 AKT1 ALKBH3 AP3D1 AURKAIP1 BCCIP BCL2L1 BCL3 BICD1 C11orf98 CCDC174 CHTOP CNTROB CREB1 CREM DCAF8 DDI1 DEAF1 DNAJB1 DRC1 EBNA1BP2 EIF2B5 FAM193B GLI3 GOLGA6C H2AZ2 HMBS HMGN1 HNRNPM HSF1 HSP90AA1 HSP90AB1 LCOR LDHA LRP6 LRRC37A2 LRSAM1 MAEA MAPT MCL1 MTCH1 MYC MYL12A NBR1 OGT PRKACA PRKCA PRKCB PRKCD PRKCG PRKCH PRKCZ PRKD3 PRKDC PSMD8 PTMA PXN RICTOR RPL15 RPL19 RPL29 RPS15 RPS19 RUNX1 SBNO1 SGK1 SGK3 SMARCA5 SMG7 SPG21 STAT2 SUGP2 TTC16 UBTF VCPIP1 YWHAG
Entrez ID		2737	2931
HPRD ID		01313	06002
Ensembl ID		ENSG00000106571	ENSG00000105723
Uniprot IDs		A0A2R8YGX0 P10071	P49840
PDB IDs		4BLD	7SXF 7SXG
Enriched GO Terms of Interacting Partners?		Embryonic Morphogenesis Anatomical Structure Morphogenesis Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription SMAD Protein Complex Heteromeric SMAD Protein Complex Regulation Of RNA Metabolic Process Positive Regulation Of RNA Metabolic Process Pattern Specification Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Biosynthetic Process I-SMAD Binding Regulation Of Primary Metabolic Process Animal Organ Development Positive Regulation Of Metabolic Process Embryonic Pattern Specification Regulation Of Signal Transduction Cell Surface Receptor Signaling Pathway SMAD Protein Signal Transduction Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression DNA-binding Transcription Factor Binding Regulation Of Smoothened Signaling Pathway Regulation Of Macromolecule Biosynthetic Process Endoderm Development Regulation Of Cell Communication Regulation Of Signaling Regulation Of Metabolic Process Anatomical Structure Formation Involved In Morphogenesis Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Catabolic Process Tissue Morphogenesis Transcription Regulator Complex Gastrulation Nucleus DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Co-SMAD Binding DNA-binding Transcription Factor Activity Negative Regulation Of Cell Differentiation Primary MiRNA Processing RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regionalization Nucleoplasm	Diacylglycerol-dependent Serine/threonine Kinase Activity Response To Peptide Hormone Negative Regulation Of Apoptotic Process Cytosol Negative Regulation Of Programmed Cell Death Regulation Of Programmed Cell Death Response To Heat Regulation Of Apoptotic Process Response To Hormone Macromolecule Metabolic Process Nucleoplasm Protein Phosphorylation Protein Serine Kinase Activity Nucleus Cytoplasmic Translation Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Cellular Response To Heat Phosphorylation Protein Serine/threonine Kinase Activity Cellular Response To Stress Protein Kinase C Signaling Response To Temperature Stimulus Positive Regulation Of Immune System Process Cytoplasm Protein Metabolic Process Cellular Response To Peptide Hormone Stimulus Response To Stress Intracellular Signal Transduction Protein Kinase Activity Leukocyte Apoptotic Process Positive Regulation Of Leukocyte Differentiation Translation Macromolecule Biosynthetic Process Positive Regulation Of Protein Localization Positive Regulation Of Metabolic Process Nitric-oxide Synthase Regulator Activity Positive Regulation Of Biosynthetic Process Positive Regulation Of Translation Cellular Response To Oxygen-containing Compound Protein Serine/threonine/tyrosine Kinase Activity CAMP/PKA Signal Transduction DNA Damage Response Negative Regulation Of Glial Cell Apoptotic Process Regulation Of Protein Localization Nucleic Acid Metabolic Process Regulation Of Cellular Component Organization Regulation Of Immune System Process Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Metabolic Process Kinase Activity
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