GLI3 and STK36

Number of citations of the paper that reports this interaction (PMID 10806483)
26

Data Source:
HPRD (in vivo)

		GLI3	STK36
Gene Name		GLI family zinc finger 3	serine/threonine kinase 36
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Cilium Mediator Complex Nuclear Speck Transcriptional Repressor Complex Primary Cilium Ciliary Tip Ciliary Base	Nucleus Cytoplasm
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Beta-catenin Binding Histone Acetyltransferase Binding Histone Deacetylase Binding Metal Ion Binding	Magnesium Ion Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Transcription Factor Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Metanephros Development Branching Involved In Ureteric Bud Morphogenesis In Utero Embryonic Development Positive Regulation Of Neuroblast Proliferation Transcription, DNA-templated Smoothened Signaling Pathway Axon Guidance Hindgut Morphogenesis Heart Development Negative Regulation Of Cell Proliferation Anterior/posterior Pattern Specification Proximal/distal Pattern Formation Protein Processing Optic Nerve Morphogenesis Hippocampus Development Smoothened Signaling Pathway Involved In Ventral Spinal Cord Interneuron Specification Smoothened Signaling Pathway Involved In Spinal Cord Motor Neuron Cell Fate Specification Forebrain Dorsal/ventral Pattern Formation Cerebral Cortex Radial Glia Guided Migration Forebrain Radial Glial Cell Differentiation Lateral Ganglionic Eminence Cell Proliferation Melanocyte Differentiation Lung Development Positive Regulation Of Chondrocyte Differentiation T Cell Differentiation In Thymus Limb Morphogenesis Wound Healing Positive Regulation Of Protein Import Into Nucleus Odontogenesis Of Dentin-containing Tooth Embryonic Digit Morphogenesis Negative Regulation Of Apoptotic Process Nose Morphogenesis Tongue Development Response To Estrogen Negative Thymic T Cell Selection Negative Regulation Of Neuron Differentiation Positive Regulation Of Osteoblast Differentiation Negative Regulation Of Smoothened Signaling Pathway Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Alpha-beta T Cell Differentiation Negative Regulation Of Alpha-beta T Cell Differentiation Embryonic Digestive Tract Morphogenesis Embryonic Digestive Tract Development Developmental Growth Camera-type Eye Morphogenesis Embryonic Skeletal System Morphogenesis Oligodendrocyte Differentiation Palate Development Frontal Suture Morphogenesis Lambdoid Suture Morphogenesis Sagittal Suture Morphogenesis Mammary Gland Specification Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning Artery Development Anterior Semicircular Canal Development Lateral Semicircular Canal Development Cell Differentiation Involved In Kidney Development Thymocyte Apoptotic Process Negative Regulation Of Canonical Wnt Signaling Pathway	Epithelial Cilium Movement Protein Phosphorylation Positive Regulation Of Hh Target Transcription Factor Activity Brain Development Post-embryonic Development Cilium Assembly Positive Regulation Of Smoothened Signaling Pathway Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Pathways		Hedgehog 'off' state Hedgehog 'on' state Signaling by Hedgehog GLI proteins bind promoters of Hh responsive genes to promote transcription GLI3 is processed to GLI3R by the proteasome
Drugs
Diseases
GWAS		Age-related macular degeneration ( 23326517) Allergic rhinitis ( 22036096)	Amyotrophic lateral sclerosis ( 22959728)
Protein-Protein Interactions		17 interactors: BTRC CREBBP CSNK1A1 GSK3A MED12 PRKCA SKI SMAD1 SMAD2 SMAD3 SMAD4 STK36 SUFU TWIST1 ZIC1 ZIC2 ZIC3	9 interactors: CDK5RAP2 CDK9 FRMPD4 GLI1 GLI2 GLI3 MAST2 MID1 SUFU
Entrez ID		2737	27148
HPRD ID		01313	09631
Ensembl ID		ENSG00000106571	ENSG00000163482
Uniprot IDs		P10071	Q9NRP7
PDB IDs
Enriched GO Terms of Interacting Partners?		Embryonic Morphogenesis Anatomical Structure Morphogenesis Positive Regulation Of Cellular Biosynthetic Process Tube Morphogenesis Tissue Morphogenesis Positive Regulation Of Transcription, DNA-templated Tube Development Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Embryo Development Epithelial Tube Morphogenesis Organ Development SMAD Protein Complex Assembly Pattern Specification Process Anatomical Structure Formation Involved In Morphogenesis Negative Regulation Of Cell Differentiation Epithelium Development Positive Regulation Of Cellular Metabolic Process Heart Development Morphogenesis Of An Epithelium Regulation Of Cell Differentiation Regulation Of Signal Transduction Cardiovascular System Development Tissue Development Multicellular Organismal Development Anatomical Structure Development Negative Regulation Of Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Signaling Stem Cell Development Organ Morphogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter System Development Regulation Of Transcription, DNA-templated Stem Cell Maintenance Positive Regulation Of Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Developmental Process Stem Cell Differentiation Regulation Of RNA Metabolic Process Transcription Initiation From RNA Polymerase II Promoter Cellular Response To Growth Factor Stimulus Transcription From RNA Polymerase II Promoter Response To Growth Factor Positive Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Gene Expression Primary MiRNA Processing	Smoothened Signaling Pathway Involved In Spinal Cord Motor Neuron Cell Fate Specification Smoothened Signaling Pathway Involved In Ventral Spinal Cord Interneuron Specification Smoothened Signaling Pathway Involved In Ventral Spinal Cord Patterning Ventral Spinal Cord Interneuron Specification Spinal Cord Motor Neuron Cell Fate Specification Ventral Spinal Cord Interneuron Fate Commitment Regulation Of Smoothened Signaling Pathway Ventral Spinal Cord Interneuron Differentiation Smoothened Signaling Pathway Dorsal/ventral Pattern Formation Notochord Regression Spinal Cord Dorsal/ventral Patterning Neuron Fate Specification Spinal Cord Patterning Pattern Specification Process Spinal Cord Motor Neuron Differentiation Proximal/distal Pattern Formation Smoothened Signaling Pathway Involved In Regulation Of Cerebellar Granule Cell Precursor Cell Proliferation Ventral Midline Development Positive Regulation Of Neural Precursor Cell Proliferation Ventral Spinal Cord Development Cell Differentiation In Spinal Cord Cerebellar Purkinje Cell-granule Cell Precursor Cell Signaling Involved In Regulation Of Granule Cell Precursor Cell Proliferation Digestive Tract Morphogenesis Neuron Fate Commitment Positive Regulation Of Cerebellar Granule Cell Precursor Proliferation Embryonic Organ Morphogenesis Hindgut Morphogenesis Notochord Morphogenesis Cell Fate Specification Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning Hindgut Development Regulation Of Neural Precursor Cell Proliferation Spinal Cord Development Regulation Of DNA Replication Tube Morphogenesis Central Nervous System Development Anatomical Structure Regression Digestive Tract Development Digestive System Development Embryonic Organ Development Notochord Development Neural Tube Development Positive Regulation Of Transcription, DNA-templated Embryonic Morphogenesis Central Nervous System Neuron Differentiation Negative Regulation Of Smoothened Signaling Pathway Dorsal/ventral Neural Tube Patterning Tube Development Lung Development
Tagcloud ?		act antitumor application blocks cancers combined component could cyclopamine directions downstream enhance glioma gynecological hedgehog induce leading malignancy management mortality oncogene ovarian pathway proliferation reduce signaling silencing therefore
Tagcloud (Difference) ?		act antitumor application blocks cancers combined component could cyclopamine directions downstream enhance glioma gynecological hedgehog induce leading malignancy management mortality oncogene ovarian pathway proliferation reduce signaling silencing therefore
Tagcloud (Intersection) ?