ZBTB46

Description		zinc finger and BTB domain containing 46
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus
	Molecular Function	Transcription Cis-regulatory Region Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Zinc Ion Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Plasmacytoid Dendritic Cell Differentiation Negative Regulation Of Leukocyte Activation Regulation Of Transcription By RNA Polymerase II Macrophage Differentiation Granulocyte Differentiation Negative Regulation Of Granulocyte Differentiation Negative Regulation Of Macrophage Differentiation Negative Regulation Of Monocyte Differentiation Dendritic Cell Differentiation Negative Regulation Of Dendritic Cell Differentiation Positive Regulation Of Dendritic Cell Differentiation
Pathways
Drugs
Diseases
GWAS		Age at first sexual intercourse ( 34211149) Allergic disease (asthma, hay fever or eczema) ( 29785011) Asthma ( 31619474) Asthma or allergic disease (pleiotropy) ( 29785011) Birth weight ( 31043758) Coronary artery disease ( 29212778) Crohn's disease ( 28067908) Femoral neck bone mineral density and trunk fat mass adjusted by trunk lean mass ( 32239398) Inflammatory bowel disease ( 28067908) Leukocyte telomere length ( 32109421) Marginal zone lymphoma or multiple sclerosis ( 31407831) Mean corpuscular volume ( 32888494) Meat-related diet ( 32066663) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Multiple sclerosis ( 21833088) Obesity-related traits ( 23251661) Processed meat consumption ( 32066663) Prostate cancer ( 23535732) Trunk fat mass adjusted for trunk lean mass ( 32239398) Type 2 diabetes (adjusted for BMI) ( 30297969) Ulcerative colitis ( 21297633 28067908) Urinary albumin-to-creatinine ratio ( 31630189)
Interacting Genes		1 interacting genes: DESI1
Entrez ID		140685
HPRD ID		16567
Ensembl ID		ENSG00000130584
Uniprot IDs		A0A494BZW5 Q6ZMU8 Q86UZ6
PDB IDs
Enriched GO Terms of Interacting Partners?		Macromolecule Depalmitoylation DeSUMOylase Activity Importin-alpha Family Protein Binding Palmitoyl-(protein) Hydrolase Activity Protein Desumoylation Long-chain Fatty Acyl-CoA Hydrolase Activity Macromolecule Deacylation Protein Export From Nucleus Nuclear Export Protein Modification By Small Protein Removal Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process
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