STK36 and CDK5RAP2

Number of citations of the paper that reports this interaction (PubMedID 12421765)
39

Data Source:
HPRD (two hybrid)

		STK36	CDK5RAP2
Description		serine/threonine kinase 36	CDK5 regulatory subunit associated protein 2
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Nucleus Cytoplasm Cytosol Cytoskeleton Cell Projection	Pericentriolar Material Spindle Pole Gamma-tubulin Ring Complex Cytoplasm Golgi Apparatus Centrosome Microtubule Organizing Center Cytosol Cytoskeleton Microtubule Cell Junction Microtubule Plus-end Ciliary Basal Body Perinuclear Region Of Cytoplasm Extracellular Exosome Mitotic Spindle Pole
	Molecular Function	Nucleotide Binding Transcription Corepressor Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Metal Ion Binding Protein Serine Kinase Activity	Transcription Cis-regulatory Region Binding Protein Binding Calmodulin Binding Microtubule Binding Tubulin Binding Protein Kinase Binding Gamma-tubulin Binding Protein-containing Complex Binding
	Biological Process	Epithelial Cilium Movement Involved In Extracellular Fluid Movement Protein Phosphorylation Microtubule-based Process Smoothened Signaling Pathway Brain Development Post-embryonic Development Cell Projection Organization Axoneme Assembly Positive Regulation Of Smoothened Signaling Pathway Regulation Of DNA-binding Transcription Factor Activity Cilium Assembly	Establishment Of Mitotic Spindle Orientation Microtubule Cytoskeleton Organization Microtubule Bundle Formation Chromosome Segregation Centrosome Cycle Centriole Replication Brain Development Neurogenesis Microtubule Organizing Center Organization Positive Regulation Of Microtubule Polymerization Regulation Of Neuron Differentiation Negative Regulation Of Neuron Differentiation Positive Regulation Of DNA-templated Transcription Negative Regulation Of Centriole Replication Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint
Pathways			Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2
Drugs		Fostamatinib
Diseases			Primary microcephaly (MCPH)
GWAS		Amyotrophic lateral sclerosis ( 22959728) Body mass index and triglycerides (pairwise) ( 33619380) Hematocrit ( 27863252) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) Male-pattern baldness ( 28196072) Red blood cell count ( 32888494) Refractive error ( 32231278)	Asthma ( 27611488) Height ( 28552196) Photic sneeze reflex ( 27182965) Response to statin therapy ( 20339536) Rheumatoid arthritis ( 24782177)
Interacting Genes		12 interacting genes: CDK5RAP2 CDK9 CLNK FRMPD4 GLI1 GLI2 GLI3 MAP1LC3B MAST2 MID1 NEIL3 SUFU	26 interacting genes: ABCA2 CDK5 CDK5R1 CLIP4 CRMP1 EEF1G ERG28 FBXO25 HAP1 KAT5 LRRK1 LUC7L2 MAGEH1 MAPRE1 NEFL PCBD1 PTN RBM48 REPS2 SENP2 STARD9 STK36 TBC1D4 TRIM37 TSNAX ZPR1
Entrez ID		27148	55755
HPRD ID		09631	09740
Ensembl ID		ENSG00000163482	ENSG00000136861
Uniprot IDs		A0A140VJW1 Q9NRP7	A0A0A0MRG9 A0A8I5KXG0 A0A8I5QKL1 B3KVI2 B9EG74 Q96SN8
PDB IDs			6X0V 8RX1 9G3Y 9G3Z 9G40 9H9P
Enriched GO Terms of Interacting Partners?		GLI-SUFU Complex Smoothened Signaling Pathway Involved In Ventral Spinal Cord Interneuron Specification Ciliary Base Spinal Cord Dorsal/ventral Patterning Ciliary Tip Dorsal/ventral Pattern Formation Smoothened Signaling Pathway Smoothened Signaling Pathway Involved In Spinal Cord Motor Neuron Cell Fate Specification Microtubule Binding Proximal/distal Pattern Formation Ventral Midline Development Double-stranded DNA Binding Hindgut Morphogenesis Pattern Specification Process Cerebellar Cortex Morphogenesis Regulation Of Smoothened Signaling Pathway Regionalization Tube Morphogenesis Lung Development Embryonic Digestive Tract Development Axoneme Osteoblast Differentiation Regulation Of Osteoblast Differentiation Pituitary Gland Development Negative Regulation Of Smoothened Signaling Pathway Mammary Gland Development Regulation Of Cell Differentiation Positive Regulation Of DNA Replication Artery Development Cilium Transcription Cis-regulatory Region Binding Notochord Regression Digestive Tract Development Lateral Semicircular Canal Development Sagittal Suture Morphogenesis Lambdoid Suture Morphogenesis Lateral Ganglionic Eminence Cell Proliferation Anterior Semicircular Canal Development Regulation Of Cellular Response To Drug Positive Regulation Of Cellular Response To Drug MCM Complex Binding Gland Development Regulation Of Protein Import Into Nucleus Odontogenesis Of Dentin-containing Tooth Ciliary Basal Body Negative Regulation Of Neuron Differentiation P-TEFb Complex Morphogenesis Of An Epithelium Semicircular Canal Development Mammary Gland Specification	Microtubule Cytoskeleton Organization Growth Cone Microtubule-based Process Protein Kinase 5 Complex Cytoskeleton Organization Cerebellum Development Establishment Of Organelle Localization Perikaryon Negative Regulation Of Motor Neuron Apoptotic Process Hippocampus Development Cell Projection Organization ESC/E(Z) Complex Regulation Of Motor Neuron Apoptotic Process Neuromuscular Junction Regulation Of Plasma Membrane Bounded Cell Projection Organization Axon Layer Formation In Cerebral Cortex Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Regulation Of Neuron Projection Development Cell Projection Regulation Of Nervous System Development Retrograde Axonal Transport Attachment Of Mitotic Spindle Microtubules To Kinetochore Microtubule Plus-end Binding Microtubule Plus-end Negative Regulation Of Cellular Component Organization Positive Regulation Of Protein Targeting To Membrane Regulation Of Neuron Apoptotic Process Organelle Localization Regulation Of Microtubule-based Process Regulation Of Intracellular Transport Neuron Projection Regeneration Diol Metabolic Process Neuron Projection Development Regulation Of Cellular Component Organization Ionotropic Glutamate Receptor Binding Spinal Cord Development Endopeptidase Regulator Activity Regulation Of Cellular Localization Regulation Of Protein Targeting To Membrane Regulation Of Synapse Organization Organelle Organization Negative Regulation Of Calcium Ion-dependent Exocytosis Of Neurotransmitter Regulation Of Postsynapse Organization Positive Regulation Of Presynaptic Cytosolic Calcium Concentration Positive Regulation Of Microtubule Polymerization DNA Endoreduplication Pre-mRNA Catabolic Process Positive Regulation Of Neurotrophin Production
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