EIF3K and CCND3

Number of citations of the paper that reports this interaction (PMID 15327989)
5

Data Source:
HPRD (in vivo, two hybrid, in vitro)

		EIF3K	CCND3
Gene Name		eukaryotic translation initiation factor 3, subunit K	cyclin D3
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Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 3 Complex Membrane Eukaryotic 43S Preinitiation Complex Eukaryotic 48S Preinitiation Complex Extracellular Vesicular Exosome	Cyclin-dependent Protein Kinase Holoenzyme Complex Nucleus Cytoplasm Membrane
	Molecular Function	Translation Initiation Factor Activity Protein Binding Ribosome Binding	Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding Protein Kinase Binding
	Biological Process	Formation Of Translation Preinitiation Complex Translation Translational Initiation Regulation Of Translational Initiation Gene Expression Cellular Protein Metabolic Process	Positive Regulation Of Protein Phosphorylation Cell Cycle Signal Transduction T Cell Proliferation Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Cell Division
Pathways		Ribosomal scanning and start codon recognition Translation initiation complex formation Formation of the ternary complex, and subsequently, the 43S complex GTP hydrolysis and joining of the 60S ribosomal subunit Translation Eukaryotic Translation Initiation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Formation of a pool of free 40S subunits Cap-dependent Translation Initiation L13a-mediated translational silencing of Ceruloplasmin expression	Cyclin D associated events in G1 Transcriptional regulation of white adipocyte differentiation G1 Phase Mitotic G1-G1/S phases Cell Cycle, Mitotic
Drugs
Diseases
GWAS			Hematological parameters ( 19820697) Mean corpuscular hemoglobin ( 20139978 19862010) Mean corpuscular volume ( 23263863 20139978 19862010) Metabolite levels (5-HIAA/ MHPG Ratio) ( 23319000) Neutrophil count ( 21507922) Red blood cell count ( 20139978) Red blood cell traits ( 23222517)
Protein-Protein Interactions		7 interactors: CCND3 EIF3C EIF3G EIF3H EIF3J EIF3L SPP1	38 interactors: AKAP8 APP AREG ATF5 ATP5C1 CASP2 CDK11B CDK14 CDK4 CDK6 CDKN1A CDKN1B CRABP2 DMTF1 DTNBP1 EFEMP2 EIF3K ETV1 FAS GC MAF1 MAPK4 MAPK6 MCM10 MYB NCOA2 NME1 NPDC1 PCNA POLD1 POLR3GL RARA RB1 RBL2 RUNX1 SIL1 TFIP11 VDR
Entrez ID		27335	896
HPRD ID		11740	00452
Ensembl ID		ENSG00000178982	ENSG00000112576
Uniprot IDs		K7EK53 Q9UBQ5	P30281 Q5T8J1
PDB IDs		1RZ4	3G33
Enriched GO Terms of Interacting Partners?		Formation Of Translation Preinitiation Complex Regulation Of Translational Initiation Ribonucleoprotein Complex Assembly Translational Initiation Regulation Of Translation Ribonucleoprotein Complex Biogenesis Posttranscriptional Regulation Of Gene Expression Cellular Macromolecular Complex Assembly Translation Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Cellular Component Assembly Cellular Protein Metabolic Process Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Protein Metabolic Process Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Negative Regulation Of Collateral Sprouting Negative Regulation Of Axon Regeneration Cytoplasmic Translation Positive Regulation Of Bone Resorption Biosynthetic Process Regulation Of Metabolic Process Regulation Of Gene Expression Regulation Of Axon Regeneration Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Cellular Process Positive Regulation Of Tissue Remodeling Decidualization Response To Vitamin D Regulation Of Bone Resorption Maternal Placenta Development Regulation Of Bone Remodeling	Mitotic Cell Cycle Cell Cycle G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Mitotic Cell Cycle Process Cell Cycle Process Cellular Metabolic Process Organ Development Regulation Of Cell Cycle Regulation Of Gene Expression Positive Regulation Of Cell Cycle Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process System Development Response To Steroid Hormone Positive Regulation Of Metabolic Process Multicellular Organismal Development Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Metabolic Process Positive Regulation Of Cell Cycle Process Anatomical Structure Development Regulation Of Cell Cycle Phase Transition Positive Regulation Of Gene Expression Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of Cellular Process Response To Lipid Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Metabolic Process Regulation Of Myeloid Cell Differentiation Response To Stimulus Developmental Process Response To Hormone Positive Regulation Of Macromolecule Biosynthetic Process Response To Hyperoxia Cellular Response To Stimulus Intracellular Receptor Signaling Pathway Regulation Of Cell Cycle Arrest Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Process Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Kinase Activity Response To Abiotic Stimulus Regulation Of Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Regulation Of Mitotic Cell Cycle
Tagcloud ?		abundances bovine caprine carcasses carefully cd36 cln3 concentrate degradable erased genorm misinterpretation mrpl39 normalisation normalising partitioning ppia productions profitability rankings reference rplp0 ruminant ruminants sets sunflower tbp top2b uxt	abi1 atlas bitbucket ctnnd1 doi driver drivers dx fbln2 figshare hindered http https identifies implies isoform ktsp m9 mitf myh11 org pparg prdm1 ralgds regulatorygenomicsupf signatures splicing switches transcript
Tagcloud (Difference) ?		abundances bovine caprine carcasses carefully cd36 cln3 concentrate degradable erased genorm misinterpretation mrpl39 normalisation normalising partitioning ppia productions profitability rankings reference rplp0 ruminant ruminants sets sunflower tbp top2b uxt	abi1 atlas bitbucket ctnnd1 doi driver drivers dx fbln2 figshare hindered http https identifies implies isoform ktsp m9 mitf myh11 org pparg prdm1 ralgds regulatorygenomicsupf signatures splicing switches transcript
Tagcloud (Intersection) ?