GLE1 and UXT

Number of citations: 0 (PubMedID 14645504)
Data Source: BioGRID (two hybrid)

		GLE1	UXT
Name		GLE1 RNA export mediator	ubiquitously expressed prefoldin like chaperone
Structure			No pdb structure
GO Annotations	Cellular Component	Extracellular Space Nucleus Nuclear Envelope Nuclear Pore Nucleolus Cytoplasm Centrosome Centriole Cytosol Membrane Nuclear Membrane Ciliary Basal Body Nuclear Pore Cytoplasmic Filaments	Chromatin Spindle Pole Nucleus Nucleoplasm Cytoplasm Centrosome Cytoskeleton Mediator Complex Protein-containing Complex Protein Folding Chaperone Complex RPAP3/R2TP/prefoldin-like Complex
	Molecular Function	Inositol Hexakisphosphate Binding Protein Binding Phospholipid Binding Translation Initiation Factor Binding Identical Protein Binding	Chromatin Binding Transcription Corepressor Activity Protein Binding Microtubule Binding Beta-tubulin Binding Actin Filament Binding
	Biological Process	MRNA Export From Nucleus Nucleocytoplasmic Transport Protein Transport Poly(A)+ MRNA Export From Nucleus MRNA Transport	Negative Regulation Of Transcription By RNA Polymerase II Microtubule Cytoskeleton Organization Apoptotic Process Centrosome Cycle Mitochondrion Transport Along Microtubule Protein Stabilization
Pathways		Transport of Mature mRNA derived from an Intron-Containing Transcript	Transcriptional Regulation by E2F6
Diseases		Lethal arthrogryposis with anterior horn cell disease Lethal congenital contractural syndrome (LCCS)	None
GWAS		Axial length ( 24144296 ) Body mass index ( 26426971 )	No GWAS studies recorded
Novel Interactors		2 novel interactors: GOLGA2 SYNE2	None recorded
Interacting Genes		4 interacting genes: KRT10 NUP155 NUP42 UXT	29 interacting genes: APP AR CECR2 DYNLT1 GLE1 KRT31 KRT40 KRTAP1-3 KRTAP10-7 KRTAP10-8 KRTAP12-3 KRTAP5-7 KRTAP5-9 LRPPRC LSM1 MACROD1 MCPH1 MPP1 NBPF19 NOTCH2NLA PAK5 RCAN1 RUNX1 SIAH1 SVIL TRIM55 TRIM63 TXNIP VHL
Entrez ID		2733	8409
HPRD ID		04536	02209
Ensembl ID		ENSG00000119392	ENSG00000126756
Uniprot IDs		A0A804HJ70 B3KMG0 Q53GS7	Q9UBK9
PDB IDs		6B4F 6B4I 6B4J	Not available
GO Terms Enriched among Interactors		Intracellular Transport Cellular Localization Establishment Of Localization In Cell Nuclear Envelope Nuclear Membrane Centrosome Cycle Microtubule Organizing Center Organization Organelle Transport Along Microtubule Nuclear Pore Protein Tetramerization Cytoskeleton Nuclear Pore Inner Ring Protein Localization To Nuclear Inner Membrane RNA Transport MRNA Transport Nuclear Export Nuclear Migration Along Microfilament Nucleokinesis Involved In Cell Motility In Cerebral Cortex Radial Glia Guided Migration Spindle Pole Positive Regulation Of Protein Glycosylation Transport Along Microtubule Nuclear Migration Along Microtubule Cytoskeleton-nuclear Membrane Anchor Activity Microtubule-based Process Cytoskeleton-dependent Intracellular Transport Golgi Disassembly Nucleobase-containing Compound Transport Regulation Of Protein Glycosylation Microtubule-based Transport Transcription-dependent Tethering Of RNA Polymerase II Gene DNA At Nuclear Periphery Cytoskeleton Organization Golgi Ribbon Formation Microtubule Binding Protein Complex Oligomerization Importin-alpha Family Protein Binding Establishment Of Organelle Localization Nuclear Transport Nucleocytoplasmic Transport Atrial Cardiac Muscle Cell Action Potential Meiotic Nuclear Membrane Microtubule Tethering Complex Golgi Cis Cisterna RPAP3/R2TP/prefoldin-like Complex Nuclear Export Signal Receptor Activity Protein Transport Asymmetric Cell Division Protein Localization To Nuclear Envelope Meiotic Spindle Assembly Protein Heterotetramerization Organelle Organization Positive Regulation Of Glycoprotein Biosynthetic Process	Intermediate Filament Keratin Filament Amyloid Fibril Formation Identical Protein Binding Supramolecular Fiber Organization Structural Constituent Of Skin Epidermis