UXT and MACROD1

Number of citations: 53 (PubMedID 21483817)
Data Source: BioGRID (pull down)

		UXT	MACROD1
Name		ubiquitously expressed prefoldin like chaperone	mono-ADP ribosylhydrolase 1
Structure		No pdb structure
GO Annotations	Cellular Component	Chromatin Spindle Pole Nucleus Nucleoplasm Cytoplasm Centrosome Cytoskeleton Mediator Complex Protein-containing Complex Protein Folding Chaperone Complex RPAP3/R2TP/prefoldin-like Complex	Nucleus Nucleoplasm Mitochondrion
	Molecular Function	Chromatin Binding Transcription Corepressor Activity Protein Binding Microtubule Binding Beta-tubulin Binding Actin Filament Binding	Protein Binding Hydrolase Activity Hydrolase Activity, Acting On Glycosyl Bonds Deacetylase Activity O-acetyl-ADP-ribose Deacetylase Activity ADP-ribosylglutamate Hydrolase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Microtubule Cytoskeleton Organization Apoptotic Process Centrosome Cycle Mitochondrion Transport Along Microtubule Protein Stabilization	DNA Damage Response Purine Nucleoside Metabolic Process Protein De-ADP-ribosylation Peptidyl-glutamate ADP-deribosylation
Pathways		Transcriptional Regulation by E2F6	None
GWAS		No GWAS studies recorded	A body shape index ( 34021172 ) Bipolar disorder ( 31043756 ) Body mass index ( 25673413 ) Body mass index and HDL-C (pairwise) ( 33619380 ) Body mass index and triglycerides (pairwise) ( 33619380 ) Fasting insulin ( 34059833 ) Fruit consumption ( 32066663 ) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716 ) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716 ) High density lipoprotein cholesterol levels ( 33339817 ) Hip circumference adjusted for BMI ( 34021172 25673412 ) Hip index ( 34021172 ) Immature fraction of reticulocytes ( 27863252 32888494 ) Mean reticulocyte volume ( 32888494 ) Serum uric acid levels ( 32514006 ) Triacylglycerol 56:6 levels ( 31560688 ) Triglyceride levels ( 33339817 ) Triglyceride levels in current drinkers ( 30698716 ) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716 ) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716 ) Urate levels ( 31578528 ) Waist circumference adjusted for body mass index ( 34021172 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 ) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625 ) Waist-to-hip ratio adjusted for body mass index ( 25673412 )
Interacting Genes		29 interacting genes: APP AR CECR2 DYNLT1 GLE1 KRT31 KRT40 KRTAP1-3 KRTAP10-7 KRTAP10-8 KRTAP12-3 KRTAP5-7 KRTAP5-9 LRPPRC LSM1 MACROD1 MCPH1 MPP1 NBPF19 NOTCH2NLA PAK5 RCAN1 RUNX1 SIAH1 SVIL TRIM55 TRIM63 TXNIP VHL	4 interacting genes: EPB41 IKBKG KPNA1 UXT
Entrez ID		8409	28992
HPRD ID		02209	17448
Ensembl ID		ENSG00000126756	ENSG00000133315
Uniprot IDs		Q9UBK9	A0A6Q8PH91 Q9BQ69
PDB IDs		Not available	2X47 6LH4
GO Terms Enriched among Interactors		Intermediate Filament Keratin Filament Amyloid Fibril Formation Identical Protein Binding Supramolecular Fiber Organization Structural Constituent Of Skin Epidermis	Mitotic Spindle Protein-containing Complex Satellite Cell Activation Involved In Skeletal Muscle Regeneration Spindle Pole Linear Polyubiquitin Binding Positive Regulation Of Protein Localization To Cell Cortex Postsynapse To Nucleus Signaling Pathway Skeletal Muscle Satellite Cell Proliferation Skeletal Muscle Satellite Cell Activation Establishment Of Organelle Localization Regulation Of Protein Localization To Cell Cortex Spectrin-associated Cytoskeleton Skeletal Muscle Cell Proliferation Establishment Of Localization In Cell NLS-dependent Protein Nuclear Import Complex RPAP3/R2TP/prefoldin-like Complex Transferrin Receptor Binding Anoikis IkappaB Kinase Complex Regulation Of Intestinal Absorption 1-phosphatidylinositol Binding