BMP10 and SLC4A1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		BMP10	SLC4A1
Description		bone morphogenetic protein 10	solute carrier family 4 member 1 (Diego blood group)
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Cell Surface Z Disc	Cytoplasm Plasma Membrane Cytoplasmic Side Of Plasma Membrane Membrane Basolateral Plasma Membrane Z Disc Cortical Cytoskeleton Extracellular Exosome Blood Microparticle Ankyrin-1 Complex
	Molecular Function	Cytokine Activity Hormone Activity Protein Binding Growth Factor Activity Telethonin Binding Receptor Serine/threonine Kinase Binding	Solute:inorganic Anion Antiporter Activity Protein Binding Cytoskeletal Protein Binding Monoatomic Anion Transmembrane Transporter Activity Bicarbonate Transmembrane Transporter Activity Chloride Transmembrane Transporter Activity Antiporter Activity Hemoglobin Binding Ankyrin Binding Protein Homodimerization Activity Protein-membrane Adaptor Activity Chloride:bicarbonate Antiporter Activity
	Biological Process	Kidney Development Cell Adhesion Heart Development Adult Heart Development Negative Regulation Of Endothelial Cell Migration Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Gene Expression Negative Regulation Of Cell Growth Negative Regulation Of Cell Migration BMP Signaling Pathway Activin Receptor Signaling Pathway Sarcomere Organization Positive Regulation Of DNA-templated Transcription Positive Regulation Of Multicellular Organismal Process Atrial Cardiac Muscle Tissue Morphogenesis Ventricular Cardiac Muscle Tissue Morphogenesis Ventricular Cardiac Muscle Cell Development Regulation Of Cardiac Muscle Contraction Cardiac Muscle Cell Proliferation Positive Regulation Of Cardiac Muscle Cell Proliferation Positive Regulation Of Sarcomere Organization Heart Trabecula Formation Positive Regulation Of SMAD Protein Signal Transduction Positive Regulation Of Cartilage Development Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Positive Regulation Of Cell Proliferation Involved In Heart Morphogenesis	Monoatomic Ion Transport Monoatomic Anion Transport Chloride Transport Intracellular Monoatomic Ion Homeostasis Blood Coagulation Bicarbonate Transport Plasma Membrane Phospholipid Scrambling Negative Regulation Of Urine Volume PH Elevation Erythrocyte Development Regulation Of Intracellular PH Transmembrane Transport Protein Localization To Plasma Membrane Chloride Transmembrane Transport Negative Regulation Of Glycolytic Process Through Fructose-6-phosphate
Pathways		Signaling by BMP Molecules associated with elastic fibres	Erythrocytes take up carbon dioxide and release oxygen Erythrocytes take up oxygen and release carbon dioxide Bicarbonate transporters Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA)
Drugs
Diseases			Hereditary stomatocytosis (HSt); Dehydrated hereditary stomatocytosis (DHS); Overhydrated hereditary stomatocytosis (OHS); Familial pseudohyperkalemia (FP) Distal renal tubular acidosis (RTA type 1) Hereditary spherocytosis (SPH) Hereditary elliptocytosis (HE)
GWAS		Chronic rhinosinusitis ( 33393196)	Appendicular lean mass ( 33097823) Bipolar disorder ( 31043756) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) hemolysis of donated blood (osmotic) ( 34014839) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 27863252 32888494) Lymphocyte count ( 32888494) Lymphocyte percentage of white cells ( 32888494) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular hemoglobin concentration ( 29403010 27863252 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Neutrophil percentage of white cells ( 32888494) Obesity-related traits ( 23251661) Red cell distribution width ( 27863252 28957414 32888494) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252) Urate levels ( 31578528)
Interacting Genes		61 interacting genes: ACVR2A ACVR2B APOA5 AQP6 ARL13B BIK BMPR2 BSCL2 BSND CCDC70 CD33 CISD2 CLDN7 COQ9 CPLX4 CREB3L1 DEXI EBP ERP29 FAM209A FCGR1A FCRL4 FFAR2 FKBP7 FNDC9 GGT6 GJB1 GPR152 GPX8 HSD17B13 IL3RA JAGN1 KIR2DL3 KIR3DL1 KLRC1 LRRC25 LRRC4C MGST3 MRPS18B MS4A3 MTIF3 PLPP4 REEP4 SERINC3 SIT1 SLC10A1 SLC10A6 SLC35H1 SLC38A1 SLC4A1 SPAG4 TCTA TMEM14B TMEM31 TMEM45B TMEM86B TMPRSS2 TNFSF14 TNFSF8 TSPAN31 VSIR	17 interacting genes: ACTC1 ADAM33 ANK1 BLOC1S6 BMP10 CA2 CA4 CANX CDKN2A CFHR5 EPB41 EPB42 LYN RHAG SLC4A1AP SYK TMEM60
Entrez ID		27302	6521
HPRD ID		09788	00175
Ensembl ID		ENSG00000163217	ENSG00000004939
Uniprot IDs		O95393	P02730
PDB IDs		6SF1 6SF3 7PPA 7PPB 7PPC 9DPY	1BH7 1BNX 1BTQ 1BTR 1BTS 1BTT 1BZK 1HYN 2BTA 2BTB 3BTB 4KY9 4YZF 7TVZ 7TW0 7TW1 7TW2 7TW3 7TW5 7TW6 7TY4 7TY6 7TY7 7TY8 7TYA 7UZ3 7UZU 7UZV 7V07 7V0K 7V0M 7V0T 7V0U 7V0Y 7V19 8CRQ 8CRR 8CRT 8CS9 8CSL 8CSV 8CSY 8CT3 8CTE 8T3R 8T3U 8T44 8T45 8T47 8T6U 8T6V
Enriched GO Terms of Interacting Partners?		Membrane Activin Receptor Activity, Type II Protein Binding Transmembrane Receptor Protein Serine/threonine Kinase Activity Plasma Membrane Activin Receptor Activity Venous Blood Vessel Development Bile Acid:sodium Symporter Activity Positive Regulation Of Activin Receptor Signaling Pathway Activin Receptor Signaling Pathway Activin Receptor Complex Lymphatic Endothelial Cell Differentiation Fc-gamma Receptor Signaling Pathway Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway BMP Receptor Activity	Ankyrin-1 Complex Secretion Secretion By Cell Spectrin-associated Cytoskeleton Carbonate Dehydratase Activity Carbon Dioxide Transport Actomyosin Structure Organization Structural Constituent Of Cytoskeleton Bicarbonate Transport Negative Regulation Of B Cell Proliferation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Stimulatory C-type Lectin Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Cellular Response To Lectin Fc-epsilon Receptor Signaling Pathway One-carbon Compound Transport Regulation Of B Cell Activation Multicellular Organismal-level Iron Ion Homeostasis Spectrin Binding Cortical Cytoskeleton Positive Regulation Of Leukocyte Apoptotic Process Regulation Of Platelet Aggregation Regulation Of Mast Cell Degranulation Negative Regulation Of Inflammatory Response To Antigenic Stimulus Negative Regulation Of B Cell Activation Negative Regulation Of Protein Serine/threonine Kinase Activity Fc-gamma Receptor Signaling Pathway Kidney Development Phosphoprotein Binding Protein-containing Complex Ligase Inhibitor Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Methylammonium Transmembrane Transporter Activity Interleukin-15 Receptor Binding Positive Regulation Of Interleukin-3 Production Bradykinin Biosynthetic Process Circadian Sleep/wake Cycle Exocytosis Regulation Of Cell Adhesion Mediated By Integrin Peptidyl-tyrosine Phosphorylation Multicellular Organismal-level Homeostasis B Cell Receptor Signaling Pathway Regulation Of Platelet Activation Cell Surface Pattern Recognition Receptor Signaling Pathway Homeostatic Process Chemical Homeostasis Fc Receptor Signaling Pathway Cardiac Muscle Tissue Morphogenesis Basolateral Plasma Membrane Positive Regulation Of Dipeptide Transmembrane Transport
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