BMP10 and CLDN7

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		BMP10	CLDN7
Description		bone morphogenetic protein 10	claudin 7
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Cell Surface Z Disc	Plasma Membrane Bicellular Tight Junction Membrane Basolateral Plasma Membrane Apicolateral Plasma Membrane Lateral Plasma Membrane Anchoring Junction
	Molecular Function	Cytokine Activity Hormone Activity Protein Binding Growth Factor Activity Telethonin Binding Receptor Serine/threonine Kinase Binding	Structural Molecule Activity Protein Binding Identical Protein Binding
	Biological Process	Kidney Development Cell Adhesion Heart Development Adult Heart Development Negative Regulation Of Endothelial Cell Migration Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Gene Expression Negative Regulation Of Cell Growth Negative Regulation Of Cell Migration BMP Signaling Pathway Activin Receptor Signaling Pathway Sarcomere Organization Positive Regulation Of DNA-templated Transcription Positive Regulation Of Multicellular Organismal Process Atrial Cardiac Muscle Tissue Morphogenesis Ventricular Cardiac Muscle Tissue Morphogenesis Ventricular Cardiac Muscle Cell Development Regulation Of Cardiac Muscle Contraction Cardiac Muscle Cell Proliferation Positive Regulation Of Cardiac Muscle Cell Proliferation Positive Regulation Of Sarcomere Organization Heart Trabecula Formation Positive Regulation Of SMAD Protein Signal Transduction Positive Regulation Of Cartilage Development Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Positive Regulation Of Cell Proliferation Involved In Heart Morphogenesis	Cell Adhesion Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Bicellular Tight Junction Assembly
Pathways		Signaling by BMP Molecules associated with elastic fibres	Tight junction interactions
Drugs
Diseases
GWAS		Chronic rhinosinusitis ( 33393196)	Birth weight ( 27680694 31043758) FEV1 ( 30804560) Lung function (FVC) ( 30804560) Multiple sclerosis ( 31604244) Offspring birth weight ( 31043758)
Interacting Genes		61 interacting genes: ACVR2A ACVR2B APOA5 AQP6 ARL13B BIK BMPR2 BSCL2 BSND CCDC70 CD33 CISD2 CLDN7 COQ9 CPLX4 CREB3L1 DEXI EBP ERP29 FAM209A FCGR1A FCRL4 FFAR2 FKBP7 FNDC9 GGT6 GJB1 GPR152 GPX8 HSD17B13 IL3RA JAGN1 KIR2DL3 KIR3DL1 KLRC1 LRRC25 LRRC4C MGST3 MRPS18B MS4A3 MTIF3 PLPP4 REEP4 SERINC3 SIT1 SLC10A1 SLC10A6 SLC35H1 SLC38A1 SLC4A1 SPAG4 TCTA TMEM14B TMEM31 TMEM45B TMEM86B TMPRSS2 TNFSF14 TNFSF8 TSPAN31 VSIR	77 interacting genes: AIG1 ANKRD46 APOD AQP2 ASGR1 BCL2L2 BET1 BMP10 C3orf52 CD53 CD72 CLN6 CMTM5 CNIH1 COL4A5 CXCL16 CXCL9 CYB561A3 CYB561D2 CYB5B CYBC1 EDDM3B EMP3 EPCAM ERG28 ERMP1 FAXDC2 FXYD6 GIMAP5 GLP1R GPR37L1 HGD IGFBP5 ITM2A JAGN1 LAT LEPROTL1 LPAR3 LSMEM2 MAL MALL MS4A13 NDUFB11 NIPAL4 NKG7 OLFM4 PGAP2 PLN RHOXF2 RPRM RTP2 SCAMP4 SCARF1 SEC22B SERTM1 SLC38A7 SLC61A1 SYNE4 TJP1 TMEM100 TMEM11 TMEM128 TMEM140 TMEM147 TMEM44 TMEM60 TMEM97 TNF TRARG1 TSPAN33 UBIAD1 UNC93B1 UPK1B UPK2 VAMP3 VAMP5 VSTM1
Entrez ID		27302	1366
HPRD ID		09788	07633
Ensembl ID		ENSG00000163217	ENSG00000181885
Uniprot IDs		O95393	A0A384ME58 F5H496 O95471
PDB IDs		6SF1 6SF3 7PPA 7PPB 7PPC 9DPY
Enriched GO Terms of Interacting Partners?		Membrane Activin Receptor Activity, Type II Protein Binding Transmembrane Receptor Protein Serine/threonine Kinase Activity Plasma Membrane Activin Receptor Activity Venous Blood Vessel Development Bile Acid:sodium Symporter Activity Positive Regulation Of Activin Receptor Signaling Pathway Activin Receptor Signaling Pathway Activin Receptor Complex Lymphatic Endothelial Cell Differentiation Fc-gamma Receptor Signaling Pathway Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway BMP Receptor Activity	Membrane Protein Binding Endoplasmic Reticulum Membrane Endoplasmic Reticulum Plasma Membrane Localization Within Membrane Transmembrane Ascorbate Ferrireductase Activity
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