BMP10 and TCTA

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		BMP10	TCTA
Description		bone morphogenetic protein 10	T cell leukemia translocation altered
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Cell Surface Z Disc	Membrane
	Molecular Function	Cytokine Activity Hormone Activity Protein Binding Growth Factor Activity Telethonin Binding Receptor Serine/threonine Kinase Binding	Protein Binding
	Biological Process	Kidney Development Cell Adhesion Heart Development Adult Heart Development Negative Regulation Of Endothelial Cell Migration Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Gene Expression Negative Regulation Of Cell Growth Negative Regulation Of Cell Migration BMP Signaling Pathway Activin Receptor Signaling Pathway Sarcomere Organization Positive Regulation Of DNA-templated Transcription Positive Regulation Of Multicellular Organismal Process Atrial Cardiac Muscle Tissue Morphogenesis Ventricular Cardiac Muscle Tissue Morphogenesis Ventricular Cardiac Muscle Cell Development Regulation Of Cardiac Muscle Contraction Cardiac Muscle Cell Proliferation Positive Regulation Of Cardiac Muscle Cell Proliferation Positive Regulation Of Sarcomere Organization Heart Trabecula Formation Positive Regulation Of SMAD Protein Signal Transduction Positive Regulation Of Cartilage Development Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Positive Regulation Of Cell Proliferation Involved In Heart Morphogenesis	Negative Regulation Of Osteoclast Differentiation Osteoclast Fusion
Pathways		Signaling by BMP Molecules associated with elastic fibres
Drugs
Diseases
GWAS		Chronic rhinosinusitis ( 33393196)	Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cognitive function ( 25644384) Coronary artery disease ( 29212778) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Extremely high intelligence ( 29520040) Household income (MTAG) ( 31844048) Inflammatory bowel disease ( 28067908) Metabolite levels ( 23823483) Regular attendance at a religious group ( 29970889) Sleep duration (short sleep) ( 30846698) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908)
Interacting Genes		61 interacting genes: ACVR2A ACVR2B APOA5 AQP6 ARL13B BIK BMPR2 BSCL2 BSND CCDC70 CD33 CISD2 CLDN7 COQ9 CPLX4 CREB3L1 DEXI EBP ERP29 FAM209A FCGR1A FCRL4 FFAR2 FKBP7 FNDC9 GGT6 GJB1 GPR152 GPX8 HSD17B13 IL3RA JAGN1 KIR2DL3 KIR3DL1 KLRC1 LRRC25 LRRC4C MGST3 MRPS18B MS4A3 MTIF3 PLPP4 REEP4 SERINC3 SIT1 SLC10A1 SLC10A6 SLC35H1 SLC38A1 SLC4A1 SPAG4 TCTA TMEM14B TMEM31 TMEM45B TMEM86B TMPRSS2 TNFSF14 TNFSF8 TSPAN31 VSIR	7 interacting genes: ADRB2 ATXN1 BMP10 CMTM7 SLC35A1 SMAD4 YIPF6
Entrez ID		27302	6988
HPRD ID		09788	15977
Ensembl ID		ENSG00000163217	ENSG00000145022
Uniprot IDs		O95393	P57738
PDB IDs		6SF1 6SF3 7PPA 7PPB 7PPC 9DPY
Enriched GO Terms of Interacting Partners?		Membrane Activin Receptor Activity, Type II Protein Binding Transmembrane Receptor Protein Serine/threonine Kinase Activity Plasma Membrane Activin Receptor Activity Venous Blood Vessel Development Bile Acid:sodium Symporter Activity Positive Regulation Of Activin Receptor Signaling Pathway Activin Receptor Signaling Pathway Activin Receptor Complex Lymphatic Endothelial Cell Differentiation Fc-gamma Receptor Signaling Pathway Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway BMP Receptor Activity	Positive Regulation Of Cell Proliferation Involved In Heart Morphogenesis Regulation Of Cell Proliferation Involved In Heart Morphogenesis Negative Regulation Of Growth Regulation Of Muscle System Process Negative Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Muscle Hypertrophy Activin Receptor Signaling Pathway Positive Regulation Of SMAD Protein Signal Transduction Regulation Of Systemic Arterial Blood Pressure By Norepinephrine-epinephrine Nucleobase-containing Compound Biosynthetic Process Transcription By RNA Polymerase II Positive Regulation Of Mini Excitatory Postsynaptic Potential Regulation Of SMAD Protein Signal Transduction Muscle Tissue Morphogenesis Ventricular Cardiac Muscle Tissue Morphogenesis Negative Regulation Of Cardiac Myofibril Assembly Cardiac Muscle Tissue Morphogenesis Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis Female Gonad Morphogenesis CMP-N-acetylneuraminate Transmembrane Transporter Activity CMP-N-acetylneuraminate Transmembrane Transport DNA-templated Transcription BMP Signaling Pathway Regulation Of Striated Muscle Cell Differentiation Beta2-adrenergic Receptor Activity Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Gonad Morphogenesis Nephrogenic Mesenchyme Morphogenesis B-1a B Cell Differentiation Norepinephrine-epinephrine-mediated Vasodilation Involved In Regulation Of Systemic Arterial Blood Pressure Beta-adrenergic Receptor Activity Positive Regulation Of Developmental Process Regulation Of System Process Activin Responsive Factor Complex Left Ventricular Cardiac Muscle Tissue Morphogenesis Metanephric Mesenchyme Morphogenesis Regulation Of Growth Regulation Of Multicellular Organismal Development Response To Psychosocial Stress Regulation Of Muscle Contraction Norepinephrine Binding Positive Regulation Of Lipophagy AMPA Selective Glutamate Receptor Signaling Pathway Negative Regulation Of Cell Growth Regulation Of Muscle Cell Differentiation Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Luteinizing Hormone Secretion Kidney Development Sulfate Binding
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