BMP10 and SERINC3

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		BMP10	SERINC3
Gene Name		bone morphogenetic protein 10	serine incorporator 3
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Cell Surface Z Disc	Golgi Apparatus Plasma Membrane Integral Component Of Membrane
	Molecular Function	Cytokine Activity Transforming Growth Factor Beta Receptor Binding Hormone Activity Protein Binding Growth Factor Activity Telethonin Binding Receptor Serine/threonine Kinase Binding	L-serine Transmembrane Transporter Activity
	Biological Process	Cell Adhesion Adult Heart Development Negative Regulation Of Endothelial Cell Migration Positive Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Extracellular Matrix Organization Negative Regulation Of Cell Growth Negative Regulation Of Cell Migration BMP Signaling Pathway Activin Receptor Signaling Pathway Regulation Of Apoptotic Process Regulation Of MAPK Cascade Sarcomere Organization Positive Regulation Of Transcription, DNA-templated Atrial Cardiac Muscle Tissue Morphogenesis Ventricular Cardiac Muscle Tissue Morphogenesis Ventricular Cardiac Muscle Cell Development Regulation Of Cardiac Muscle Contraction Cardiac Muscle Cell Proliferation Positive Regulation Of Cardiac Muscle Cell Proliferation Positive Regulation Of Sarcomere Organization Heart Trabecula Formation Pathway-restricted SMAD Protein Phosphorylation SMAD Protein Signal Transduction Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Positive Regulation Of Cell Proliferation Involved In Heart Morphogenesis	Phosphatidylserine Metabolic Process Sphingolipid Metabolic Process L-serine Transport Positive Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway
Pathways		Molecules associated with elastic fibres Elastic fibre formation
Drugs
Diseases
GWAS			Bipolar disorder ( 22925353) Ulcerative colitis ( 21297633)
Protein-Protein Interactions		4 interactors: ACVR2A ACVR2B BMPR2 SERINC3	2 interactors: BMP10 RPS15
Entrez ID		27302	10955
HPRD ID		09788	06201
Ensembl ID		ENSG00000163217	ENSG00000132824
Uniprot IDs		O95393	B4DUE9 Q13530
PDB IDs
Enriched GO Terms of Interacting Partners?		Activin Receptor Signaling Pathway Positive Regulation Of Bone Mineralization Positive Regulation Of Biomineral Tissue Development Regulation Of Bone Mineralization Positive Regulation Of Osteoblast Differentiation BMP Signaling Pathway Positive Regulation Of Ossification Positive Regulation Of Activin Receptor Signaling Pathway Lymphatic Endothelial Cell Differentiation Regulation Of Osteoblast Differentiation Mesoderm Development Lymphangiogenesis Lymph Vessel Morphogenesis Gastrulation Regulation Of Ossification Venous Blood Vessel Development Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Anterior/posterior Pattern Specification Retina Vasculature Development In Camera-type Eye Regulation Of Activin Receptor Signaling Pathway Lymph Vessel Development Signal Transduction By Phosphorylation Positive Regulation Of Signal Transduction Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Blood Vessel Remodeling Regulation Of Pathway-restricted SMAD Protein Phosphorylation Pattern Specification Process Gastrulation With Mouth Forming Second Artery Development Skeletal System Development Endothelial Cell Differentiation Regulation Of BMP Signaling Pathway Embryonic Morphogenesis Endothelium Development Positive Regulation Of Protein Phosphorylation Determination Of Left/right Symmetry Tissue Remodeling Determination Of Bilateral Symmetry Positive Regulation Of Cell Differentiation Positive Regulation Of Phosphorylation Regulation Of Signal Transduction Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Protein Modification Process Phosphate-containing Compound Metabolic Process Retina Development In Camera-type Eye Regulation Of Signaling Regulation Of Lung Blood Pressure Negative Regulation Of Chondrocyte Proliferation Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process	Ribosomal Small Subunit Export From Nucleus Organelle Assembly Positive Regulation Of Sarcomere Organization Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Atrial Cardiac Muscle Tissue Morphogenesis Ribosomal Subunit Export From Nucleus Negative Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Muscle Hypertrophy Ribosomal Small Subunit Assembly Positive Regulation Of Cell Proliferation Involved In Heart Morphogenesis Pathway-restricted SMAD Protein Phosphorylation Heart Trabecula Formation Adult Heart Development Regulation Of Sarcomere Organization Positive Regulation Of Cardiac Muscle Hypertrophy Ventricular Cardiac Muscle Cell Development Cardiac Muscle Cell Proliferation Positive Regulation Of Organelle Assembly Heart Trabecula Morphogenesis Ribosome Assembly Ventricular Cardiac Muscle Cell Differentiation Regulation Of Cardiac Muscle Hypertrophy Activin Receptor Signaling Pathway Positive Regulation Of Cardiac Muscle Cell Proliferation Cardiac Atrium Morphogenesis Regulation Of Heart Morphogenesis Cardiac Muscle Tissue Growth Negative Regulation Of Endothelial Cell Migration Positive Regulation Of Heart Growth Ribosomal Small Subunit Biogenesis Ventricular Cardiac Muscle Tissue Morphogenesis Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Regulation Of Cardiac Muscle Cell Proliferation Negative Regulation Of Epithelial Cell Migration Positive Regulation Of Organ Growth Trabecula Morphogenesis Sarcomere Organization Ventricular Cardiac Muscle Tissue Development Regulation Of Pathway-restricted SMAD Protein Phosphorylation SMAD Protein Signal Transduction Cardiac Muscle Tissue Morphogenesis Regulation Of Heart Growth Positive Regulation Of Striated Muscle Cell Differentiation Regulation Of Cardiac Muscle Tissue Development Muscle Tissue Morphogenesis Positive Regulation Of Striated Muscle Tissue Development Positive Regulation Of Muscle Tissue Development Cardiac Muscle Cell Development Muscle Organ Morphogenesis Cardiac Ventricle Morphogenesis
Tagcloud ?		activin alk1 antitumor bmp9 cohorts correlative dalantercept diuretic edema escalating evaluable fatigue formerly gross hemorrhage morphogenetic perforations pharmacodynamic pharmacodynamics pharmacokinetics proteinuria recistv1 refractory responded subcutaneously telangiectasia tolerability toxicities underway
Tagcloud (Difference) ?		activin alk1 antitumor bmp9 cohorts correlative dalantercept diuretic edema escalating evaluable fatigue formerly gross hemorrhage morphogenetic perforations pharmacodynamic pharmacodynamics pharmacokinetics proteinuria recistv1 refractory responded subcutaneously telangiectasia tolerability toxicities underway
Tagcloud (Intersection) ?