VENTX and TLE2

Number of citations of the paper that reports this interaction (PMID 20211142)
148

Data Source:
BioGRID (two hybrid)

		VENTX	TLE2
Gene Name		VENT homeobox	transducin-like enhancer of split 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus	Extracellular Space Nucleus Nucleoplasm
	Molecular Function	Sequence-specific DNA Binding	Transcription Corepressor Activity Protein Binding
	Biological Process	Regulation Of Transcription, DNA-templated Multicellular Organismal Development	Transcription, DNA-templated Signal Transduction Notch Signaling Pathway Organ Morphogenesis Wnt Signaling Pathway Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Canonical Wnt Signaling Pathway
Pathways			Signaling by NOTCH1 HD Domain Mutants in Cancer Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer APC truncation mutants have impaired AXIN binding misspliced GSK3beta mutants stabilize beta-catenin T41 mutants of beta-catenin aren't phosphorylated TCF7L2 mutants don't bind CTBP truncated APC mutants destabilize the destruction complex Signaling by Wnt deactivation of the beta-catenin transactivating complex APC truncation mutants are not K63 polyubiquitinated Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant S37 mutants of beta-catenin aren't phosphorylated Degradation of beta-catenin by the destruction complex S33 mutants of beta-catenin aren't phosphorylated AXIN mutants destabilize the destruction complex, activating WNT signaling RNF mutants show enhanced WNT signaling and proliferation Signaling by NOTCH1 XAV939 inhibits tankyrase, stabilizing AXIN Signaling by NOTCH1 in Cancer truncations of AMER1 destabilize the destruction complex FBXW7 Mutants and NOTCH1 in Cancer misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling Signaling by NOTCH formation of the beta-catenin:TCF transactivating complex phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex AXIN missense mutants destabilize the destruction complex S45 mutants of beta-catenin aren't phosphorylated repression of WNT target genes NOTCH1 Intracellular Domain Regulates Transcription deletions in the AMER1 gene destabilize the destruction complex AMER1 mutants destabilize the destruction complex TCF dependent signaling in response to WNT deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling Signaling by NOTCH1 PEST Domain Mutants in Cancer Signaling by WNT in cancer
Drugs
Diseases
GWAS
Protein-Protein Interactions		10 interactors: C1orf94 DAB1 IRF9 KRTAP12-2 KRTAP12-4 RBPMS TBX15 TBX22 TLE1 TLE2	16 interactors: BARHL1 EMX2 FOXA3 H3F3A HES1 HMGB1 LEF1 MSX1 MSX2 PAX9 PRDM1 RUNX1 TLE1 TLX3 UTY VENTX
Entrez ID		27287	7089
HPRD ID		06197	03025
Ensembl ID		ENSG00000151650	ENSG00000065717
Uniprot IDs		O95231	B4DE62 K7EMK7 Q04725
PDB IDs
Enriched GO Terms of Interacting Partners?		Transcription, DNA-templated RNA Biosynthetic Process RNA Metabolic Process Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of Gene Expression Cell-cell Adhesion Involved In Neuronal-glial Interactions Involved In Cerebral Cortex Radial Glia Guided Migration Nucleobase-containing Compound Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Cerebellum Structural Organization Notch Signaling Pathway Lateral Motor Column Neuron Migration Nitrogen Compound Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Spinal Cord Motor Neuron Migration Negative Regulation Of Wnt Signaling Pathway Radial Glia Guided Migration Of Purkinje Cell Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Metabolic Process Organ Morphogenesis Wnt Signaling Pathway Negative Regulation Of Signal Transduction Anatomical Structure Morphogenesis Type I Interferon Biosynthetic Process Regulation Of Wnt Signaling Pathway Negative Regulation Of Signaling Positive Regulation Of SMAD Protein Import Into Nucleus Golgi Localization Negative Regulation Of Anoikis Multicellular Organismal Development Type I Interferon Production Negative Regulation Of Astrocyte Differentiation Regulation Of Signal Transduction Regulation Of SMAD Protein Import Into Nucleus Regulation Of Anoikis	Regulation Of Gene Expression Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of DNA Binding Positive Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Multicellular Organismal Development Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process System Development Organ Morphogenesis Developmental Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Organ Development Transcription, DNA-templated Negative Regulation Of Transcription From RNA Polymerase II Promoter Anatomical Structure Development RNA Biosynthetic Process Anterior/posterior Pattern Specification Cell Migration Regulation Of Binding Positive Regulation Of Transcription, DNA-templated Cell Motility Mesenchymal Cell Development Cell Differentiation Positive Regulation Of Mesenchymal Cell Apoptotic Process Embryonic Nail Plate Morphogenesis Gene Expression Central Nervous System Development Odontogenesis Mesenchymal Cell Differentiation Face Morphogenesis Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Positive Regulation Of BMP Signaling Pathway Nucleobase-containing Compound Metabolic Process Activation Of Meiosis Generation Of Neurons Head Morphogenesis Positive Regulation Of Cellular Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process
Tagcloud ?		challenge clonogenicity engraftment ex expansion helped hematopoietic homeobox hsc il2rgamma2 implicated intensive intrinsic investigations mechanistically mpp mpps multipotent nevertheless null ontogenesis pools preserve progenitor regulators scid strikingly suppression wnt
Tagcloud (Difference) ?		challenge clonogenicity engraftment ex expansion helped hematopoietic homeobox hsc il2rgamma2 implicated intensive intrinsic investigations mechanistically mpp mpps multipotent nevertheless null ontogenesis pools preserve progenitor regulators scid strikingly suppression wnt
Tagcloud (Intersection) ?