CNOT7 and FOXC2

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		CNOT7	FOXC2
Description		CCR4-NOT transcription complex subunit 7	forkhead box C2
Image
GO Annotations	Cellular Component	P-body Nucleus Cytoplasm Cytosol Membrane Nuclear Body Nuclear Speck CCR4-NOT Complex CCR4-NOT Core Complex Cytoplasmic Ribonucleoprotein Granule	Chromatin Nucleus Nucleoplasm Nuclear Body
	Molecular Function	3'-5'-RNA Exonuclease Activity Nucleic Acid Binding Transcription Corepressor Activity RNA Binding Nuclease Activity Exonuclease Activity RNA Exonuclease Activity Poly(A)-specific Ribonuclease Activity Protein Binding Hydrolase Activity PiRNA Binding Metal Ion Binding DNA-binding Transcription Factor Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Chromatin DNA Binding Identical Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding Promoter-specific Chromatin Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Poly(A) Tail Shortening Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Regulation Of Translation Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Negative Regulation Of Gene Expression Regulatory NcRNA-mediated Gene Silencing P-body Assembly MiRNA-mediated Gene Silencing By MRNA Destabilization Regulation Of Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of Viral Genome Replication Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Defense Response To Virus Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Negative Regulation Of Type I Interferon-mediated Signaling Pathway Positive Regulation Of MRNA Catabolic Process PiRNA-mediated Gene Silencing By MRNA Destabilization Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay	Negative Regulation Of Transcription By RNA Polymerase II Skeletal System Development Ossification Blood Vessel Development Branching Involved In Blood Vessel Morphogenesis Metanephros Development Ureteric Bud Development Somitogenesis Kidney Development Lymph Vessel Development Lymphangiogenesis Blood Vessel Remodeling Heart Morphogenesis Apoptotic Process Involved In Outflow Tract Morphogenesis Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Notch Signaling Pathway Mesoderm Development Heart Development Cell Population Proliferation Insulin Receptor Signaling Pathway Anatomical Structure Morphogenesis Response To Hormone Positive Regulation Of Endothelial Cell Migration Neural Crest Cell Development Cell Differentiation Collagen Fibril Organization Positive Regulation Of Cell Adhesion Mediated By Integrin Embryonic Heart Tube Development Positive Regulation Of Vascular Wound Healing Camera-type Eye Development Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Organ Growth Vascular Endothelial Growth Factor Receptor Signaling Pathway Paraxial Mesoderm Formation Paraxial Mesodermal Cell Fate Commitment Embryonic Cranial Skeleton Morphogenesis Embryonic Viscerocranium Morphogenesis Embryonic Skeletal System Morphogenesis Artery Morphogenesis Ventricular Cardiac Muscle Tissue Morphogenesis Cardiac Muscle Cell Proliferation Glomerular Endothelium Development Podocyte Differentiation Glomerular Mesangial Cell Development Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Blood Vessel Diameter Maintenance Negative Regulation Of Cold-induced Thermogenesis Negative Regulation Of Apoptotic Process Involved In Outflow Tract Morphogenesis
Pathways		Deadenylation of mRNA TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain M-decay: degradation of maternal mRNAs by maternally stored factors	Formation of intermediate mesoderm Formation of the ureteric bud
Drugs
Diseases			Lymphedemas, including: Lymphedema, hereditary I; Lymphedema-distichiasis syndrome (LD); Hypotrichosis-lymphedema-telangiectasia syndrome (HLTS)
GWAS			Metabolite levels ( 23823483) Nonsyndromic cleft palate ( 31609978) Nose size ( 27182965) Sepsis in extremely premature infants ( 28283553) Systemic juvenile idiopathic arthritis ( 27927641)
Interacting Genes		29 interacting genes: APP BTG1 BTG2 BTG3 CDK1 CDK2 CDK4 CDK6 CNOT6 FBXO7 FHL3 FOXC2 HOXD4 IKBKG LSM3 MRFAP1L1 NMI OBI1 PABPC1 PIAS1 PSMC1 PSMC2 SCARA3 SH3GLB2 TCP11L1 TEX11 TOB1 TOB2 TSG101	8 interacting genes: CNOT7 GOLGA2 KRTAP3-3 METTL27 NPHS2 RBPMS TAX1BP1 TRIM27
Entrez ID		29883	2303
HPRD ID		05370	03869
Ensembl ID		ENSG00000198791	ENSG00000176692
Uniprot IDs		Q96IQ6 Q9UIV1	Q99958
PDB IDs		2D5R 4GMJ 7AX1 7VOI	1D5V 6AKO 6AKP 6LBM 6O3T
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Catabolic Process Regulation Of Cell Population Proliferation Cyclin Binding Cyclin-dependent Protein Serine/threonine Kinase Activity Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Cyclin-dependent Protein Kinase Holoenzyme Complex Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Negative Regulation Of Cell Population Proliferation Regulation Of Protein Metabolic Process Mitotic Cell Cycle Phase Transition Cyclin-dependent Protein Kinase Activity Cell Cycle Phase Transition Positive Regulation Of Metabolic Process Nucleus Regulation Of Primary Metabolic Process Regulation Of Metabolic Process Regulation Of Mitotic Cell Cycle Positive Regulation Of Proteolysis Transcription Corepressor Activity Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Proteolysis Histone Kinase Activity Proteasome-activating Activity Positive Regulation Of MRNA Catabolic Process Negative Regulation Of Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Cell Cycle Regulation Of Cell Cycle G2/M Phase Transition Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of MRNA Metabolic Process Cellular Response To Phorbol 13-acetate 12-myristate Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Response To Phorbol 13-acetate 12-myristate Proteasome Regulatory Particle, Base Subcomplex Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Mitotic Cell Cycle Phase Transition Nucleoplasm CCR4-NOT Complex
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